Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer

Abstract Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution in several tumor types. In this study, a set of immune biomarkers (myeloid derived suppressor cells, regulatory T cells, and OX40 + and PD-1 + T lymphocytes counts) in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Natalia Palazón-Carrión, Carlos Jiménez-Cortegana, M. Luisa Sánchez-León, Fernando Henao-Carrasco, Esteban Nogales-Fernández, Massimo Chiesa, Rosalía Caballero, Federico Rojo, María-Adoración Nieto-García, Víctor Sánchez-Margalet, Luis de la Cruz-Merino, the Spanish Breast Cancer Group (GEICAM) and the Spanish Group for Immunobiotherapy of Cancer (GÉTICA)
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7ffda4053d44faa99e7001d804ed3ac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7ffda4053d44faa99e7001d804ed3ac
record_format	dspace
spelling	oai:doaj.org-article:f7ffda4053d44faa99e7001d804ed3ac2021-12-02T16:08:06ZCirculating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer10.1038/s41598-021-93838-w2045-2322https://doaj.org/article/f7ffda4053d44faa99e7001d804ed3ac2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93838-whttps://doaj.org/toc/2045-2322Abstract Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution in several tumor types. In this study, a set of immune biomarkers (myeloid derived suppressor cells, regulatory T cells, and OX40 + and PD-1 + T lymphocytes counts) in peripheral blood of patients diagnosed with advanced breast cancer were analyzed along of first line antineoplastic therapy. Subsequently, a comparison between groups with clinical benefit versus progression of disease and with a healthy women cohort was executed. Results reflected that patients showed higher basal levels of myeloid derived suppressor cells (35.43, IR = 180.73 vs 17.53, IR = 16.96 cells/μl; p = 0.001) and regulatory T cells (32.05, IR = 29.84 vs 22.61, IR = 13.57 cells/μl; p = 0.001) in comparison with healthy women. Furthermore, an increase in the number of activated T lymphocytes (expressing OX40), a decrease of immune inhibitory cells (MDSCs and Tregs) and inhibited T lymphocytes (expressing PD-1) were observed along the treatment in patients with clinical benefit (p ≤ 0.001). The opposite trend was observed in the case of disease progression. These findings suggest that some critical immune elements can be easily detected and measured in peripheral blood, which open a new opportunity for translational research, as they seem to be correlated with clinical evolution, at least in ABC.Natalia Palazón-CarriónCarlos Jiménez-CorteganaM. Luisa Sánchez-LeónFernando Henao-CarrascoEsteban Nogales-FernándezMassimo ChiesaRosalía CaballeroFederico RojoMaría-Adoración Nieto-GarcíaVíctor Sánchez-MargaletLuis de la Cruz-Merinothe Spanish Breast Cancer Group (GEICAM) and the Spanish Group for Immunobiotherapy of Cancer (GÉTICA)Nature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natalia Palazón-Carrión Carlos Jiménez-Cortegana M. Luisa Sánchez-León Fernando Henao-Carrasco Esteban Nogales-Fernández Massimo Chiesa Rosalía Caballero Federico Rojo María-Adoración Nieto-García Víctor Sánchez-Margalet Luis de la Cruz-Merino the Spanish Breast Cancer Group (GEICAM) and the Spanish Group for Immunobiotherapy of Cancer (GÉTICA) Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
description	Abstract Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution in several tumor types. In this study, a set of immune biomarkers (myeloid derived suppressor cells, regulatory T cells, and OX40 + and PD-1 + T lymphocytes counts) in peripheral blood of patients diagnosed with advanced breast cancer were analyzed along of first line antineoplastic therapy. Subsequently, a comparison between groups with clinical benefit versus progression of disease and with a healthy women cohort was executed. Results reflected that patients showed higher basal levels of myeloid derived suppressor cells (35.43, IR = 180.73 vs 17.53, IR = 16.96 cells/μl; p = 0.001) and regulatory T cells (32.05, IR = 29.84 vs 22.61, IR = 13.57 cells/μl; p = 0.001) in comparison with healthy women. Furthermore, an increase in the number of activated T lymphocytes (expressing OX40), a decrease of immune inhibitory cells (MDSCs and Tregs) and inhibited T lymphocytes (expressing PD-1) were observed along the treatment in patients with clinical benefit (p ≤ 0.001). The opposite trend was observed in the case of disease progression. These findings suggest that some critical immune elements can be easily detected and measured in peripheral blood, which open a new opportunity for translational research, as they seem to be correlated with clinical evolution, at least in ABC.
format	article
author	Natalia Palazón-Carrión Carlos Jiménez-Cortegana M. Luisa Sánchez-León Fernando Henao-Carrasco Esteban Nogales-Fernández Massimo Chiesa Rosalía Caballero Federico Rojo María-Adoración Nieto-García Víctor Sánchez-Margalet Luis de la Cruz-Merino the Spanish Breast Cancer Group (GEICAM) and the Spanish Group for Immunobiotherapy of Cancer (GÉTICA)
author_facet	Natalia Palazón-Carrión Carlos Jiménez-Cortegana M. Luisa Sánchez-León Fernando Henao-Carrasco Esteban Nogales-Fernández Massimo Chiesa Rosalía Caballero Federico Rojo María-Adoración Nieto-García Víctor Sánchez-Margalet Luis de la Cruz-Merino the Spanish Breast Cancer Group (GEICAM) and the Spanish Group for Immunobiotherapy of Cancer (GÉTICA)
author_sort	Natalia Palazón-Carrión
title	Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
title_short	Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
title_full	Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
title_fullStr	Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
title_full_unstemmed	Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
title_sort	circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f7ffda4053d44faa99e7001d804ed3ac
work_keys_str_mv	AT nataliapalazoncarrion circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer AT carlosjimenezcortegana circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer AT mluisasanchezleon circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer AT fernandohenaocarrasco circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer AT estebannogalesfernandez circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer AT massimochiesa circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer AT rosaliacaballero circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer AT federicorojo circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer AT mariaadoracionnietogarcia circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer AT victorsanchezmargalet circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer AT luisdelacruzmerino circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer AT thespanishbreastcancergroupgeicamandthespanishgroupforimmunobiotherapyofcancergetica circulatingimmunebiomarkersinperipheralbloodcorrelatewithclinicaloutcomesinadvancedbreastcancer
_version_	1718384632587616256

Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer

Ejemplares similares