Experimental study of the effect of Caffeine on Pentazocine analgesia
Objective: In this study the effect of caffeine on pentazocine analgesia in rats was assessed by “Tail-immersion test”. Methods: This study was performed by “Tail-immersion test”. Animals were juvenile M-Mari Rats (Male or female) weighing 120-160 gr. Findings: The average control latencies in “Tail...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN FA |
| Publicado: |
Babol University of Medical Sciences
1999
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/f801e058b40848bc814e161b8867cd79 |
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| Sumario: | Objective: In this study the effect of caffeine on pentazocine analgesia in rats was assessed by “Tail-immersion test”. Methods: This study was performed by “Tail-immersion test”. Animals were juvenile M-Mari Rats (Male or female) weighing 120-160 gr. Findings: The average control latencies in “Tail-immersion test” were about 1.5-2 sec. The response latencies of rats which had been given caffeine (25, 50, 75 and 100 mg/kg I.P) or propyleneglycol (40%) were not significant comparing to those receiving an injection of the control vehicle over the 2 hours of testing period. Conclusion: The response latencies of pretreated parts with caffeine (100 mg/kg I.P) during 15, 30, 45 and 60 minutes after the injection of (10, 15, 20 and 25 mg/kg S.C) of pentazocine were significantly higher than those of control group. But injection of lower doses of caffeine and pentazocine did not show a significant analgesic effect compared with the control group. |
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