Experimental study of the effect of Caffeine on Pentazocine analgesia

Objective: In this study the effect of caffeine on pentazocine analgesia in rats was assessed by “Tail-immersion test”. Methods: This study was performed by “Tail-immersion test”. Animals were juvenile M-Mari Rats (Male or female) weighing 120-160 gr. Findings: The average control latencies in “Tail...

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Autores principales:	A Arzi, A Dehghani
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 1999
Materias:	analgesia pentazocine caffeine drug interaction Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f801e058b40848bc814e161b8867cd79
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spelling	oai:doaj.org-article:f801e058b40848bc814e161b8867cd792021-11-10T09:24:10ZExperimental study of the effect of Caffeine on Pentazocine analgesia1561-41072251-7170https://doaj.org/article/f801e058b40848bc814e161b8867cd791999-01-01T00:00:00Zhttp://jbums.org/article-1-2962-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: In this study the effect of caffeine on pentazocine analgesia in rats was assessed by “Tail-immersion test”. Methods: This study was performed by “Tail-immersion test”. Animals were juvenile M-Mari Rats (Male or female) weighing 120-160 gr. Findings: The average control latencies in “Tail-immersion test” were about 1.5-2 sec. The response latencies of rats which had been given caffeine (25, 50, 75 and 100 mg/kg I.P) or propyleneglycol (40%) were not significant comparing to those receiving an injection of the control vehicle over the 2 hours of testing period. Conclusion: The response latencies of pretreated parts with caffeine (100 mg/kg I.P) during 15, 30, 45 and 60 minutes after the injection of (10, 15, 20 and 25 mg/kg S.C) of pentazocine were significantly higher than those of control group. But injection of lower doses of caffeine and pentazocine did not show a significant analgesic effect compared with the control group.A ArziA DehghaniBabol University of Medical Sciencesarticleanalgesiapentazocinecaffeinedrug interactionMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 1, Iss 1, Pp 7-11 (1999)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	analgesia pentazocine caffeine drug interaction Medicine R Medicine (General) R5-920
spellingShingle	analgesia pentazocine caffeine drug interaction Medicine R Medicine (General) R5-920 A Arzi A Dehghani Experimental study of the effect of Caffeine on Pentazocine analgesia
description	Objective: In this study the effect of caffeine on pentazocine analgesia in rats was assessed by “Tail-immersion test”. Methods: This study was performed by “Tail-immersion test”. Animals were juvenile M-Mari Rats (Male or female) weighing 120-160 gr. Findings: The average control latencies in “Tail-immersion test” were about 1.5-2 sec. The response latencies of rats which had been given caffeine (25, 50, 75 and 100 mg/kg I.P) or propyleneglycol (40%) were not significant comparing to those receiving an injection of the control vehicle over the 2 hours of testing period. Conclusion: The response latencies of pretreated parts with caffeine (100 mg/kg I.P) during 15, 30, 45 and 60 minutes after the injection of (10, 15, 20 and 25 mg/kg S.C) of pentazocine were significantly higher than those of control group. But injection of lower doses of caffeine and pentazocine did not show a significant analgesic effect compared with the control group.
format	article
author	A Arzi A Dehghani
author_facet	A Arzi A Dehghani
author_sort	A Arzi
title	Experimental study of the effect of Caffeine on Pentazocine analgesia
title_short	Experimental study of the effect of Caffeine on Pentazocine analgesia
title_full	Experimental study of the effect of Caffeine on Pentazocine analgesia
title_fullStr	Experimental study of the effect of Caffeine on Pentazocine analgesia
title_full_unstemmed	Experimental study of the effect of Caffeine on Pentazocine analgesia
title_sort	experimental study of the effect of caffeine on pentazocine analgesia
publisher	Babol University of Medical Sciences
publishDate	1999
url	https://doaj.org/article/f801e058b40848bc814e161b8867cd79
work_keys_str_mv	AT aarzi experimentalstudyoftheeffectofcaffeineonpentazocineanalgesia AT adehghani experimentalstudyoftheeffectofcaffeineonpentazocineanalgesia
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Experimental study of the effect of Caffeine on Pentazocine analgesia

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