Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids

Functional bowel disorders such as irritable bowel syndrome (IBS) are common, multifactorial and have a major impact on the quality of life of individuals diagnosed with the condition. Heterogeneity in symptom manifestation, which includes changes in bowel habit and visceral pain sensitivity, are an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Róisín Ní Dhonnabháín, Qiao Xiao, Dervla O’Malley
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	TGR5 FXR lithocholic acid microbiome IBS bile salt hydrolase Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/f804cf6ac8d94c29b9e189ba22695d2c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f804cf6ac8d94c29b9e189ba22695d2c
record_format	dspace
spelling	oai:doaj.org-article:f804cf6ac8d94c29b9e189ba22695d2c2021-12-01T18:34:44ZAberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids1664-239210.3389/fendo.2021.745190https://doaj.org/article/f804cf6ac8d94c29b9e189ba22695d2c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.745190/fullhttps://doaj.org/toc/1664-2392Functional bowel disorders such as irritable bowel syndrome (IBS) are common, multifactorial and have a major impact on the quality of life of individuals diagnosed with the condition. Heterogeneity in symptom manifestation, which includes changes in bowel habit and visceral pain sensitivity, are an indication of the complexity of the underlying pathophysiology. It is accepted that dysfunctional gut-brain communication, which incorporates efferent and afferent branches of the peripheral nervous system, circulating endocrine hormones and local paracrine and neurocrine factors, such as host and microbially-derived signaling molecules, underpins symptom manifestation. This review will focus on the potential role of hepatic bile acids in modulating gut-to-brain signaling in IBS patients. Bile acids are amphipathic molecules synthesized in the liver, which facilitate digestion and absorption of dietary lipids. They are also important bioactive signaling molecules however, binding to bile acid receptors which are expressed on many different cell types. Bile acids have potent anti-microbial actions and thereby shape intestinal bacterial profiles. In turn, bacteria with bile salt hydrolase activity initiate the critical first step in transforming primary bile acids into secondary bile acids. Individuals with IBS are reported to have altered microbial profiles and modified bile acid pools. We have assessed the evidence to support a role for bile acids in the pathophysiology underlying the manifestation of IBS symptoms.Róisín Ní DhonnabháínQiao XiaoQiao XiaoDervla O’MalleyDervla O’MalleyFrontiers Media S.A.articleTGR5FXRlithocholic acidmicrobiomeIBSbile salt hydrolaseDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TGR5 FXR lithocholic acid microbiome IBS bile salt hydrolase Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	TGR5 FXR lithocholic acid microbiome IBS bile salt hydrolase Diseases of the endocrine glands. Clinical endocrinology RC648-665 Róisín Ní Dhonnabháín Qiao Xiao Qiao Xiao Dervla O’Malley Dervla O’Malley Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids
description	Functional bowel disorders such as irritable bowel syndrome (IBS) are common, multifactorial and have a major impact on the quality of life of individuals diagnosed with the condition. Heterogeneity in symptom manifestation, which includes changes in bowel habit and visceral pain sensitivity, are an indication of the complexity of the underlying pathophysiology. It is accepted that dysfunctional gut-brain communication, which incorporates efferent and afferent branches of the peripheral nervous system, circulating endocrine hormones and local paracrine and neurocrine factors, such as host and microbially-derived signaling molecules, underpins symptom manifestation. This review will focus on the potential role of hepatic bile acids in modulating gut-to-brain signaling in IBS patients. Bile acids are amphipathic molecules synthesized in the liver, which facilitate digestion and absorption of dietary lipids. They are also important bioactive signaling molecules however, binding to bile acid receptors which are expressed on many different cell types. Bile acids have potent anti-microbial actions and thereby shape intestinal bacterial profiles. In turn, bacteria with bile salt hydrolase activity initiate the critical first step in transforming primary bile acids into secondary bile acids. Individuals with IBS are reported to have altered microbial profiles and modified bile acid pools. We have assessed the evidence to support a role for bile acids in the pathophysiology underlying the manifestation of IBS symptoms.
format	article
author	Róisín Ní Dhonnabháín Qiao Xiao Qiao Xiao Dervla O’Malley Dervla O’Malley
author_facet	Róisín Ní Dhonnabháín Qiao Xiao Qiao Xiao Dervla O’Malley Dervla O’Malley
author_sort	Róisín Ní Dhonnabháín
title	Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids
title_short	Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids
title_full	Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids
title_fullStr	Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids
title_full_unstemmed	Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids
title_sort	aberrant gut-to-brain signaling in irritable bowel syndrome - the role of bile acids
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f804cf6ac8d94c29b9e189ba22695d2c
work_keys_str_mv	AT roisinnidhonnabhain aberrantguttobrainsignalinginirritablebowelsyndrometheroleofbileacids AT qiaoxiao aberrantguttobrainsignalinginirritablebowelsyndrometheroleofbileacids AT qiaoxiao aberrantguttobrainsignalinginirritablebowelsyndrometheroleofbileacids AT dervlaomalley aberrantguttobrainsignalinginirritablebowelsyndrometheroleofbileacids AT dervlaomalley aberrantguttobrainsignalinginirritablebowelsyndrometheroleofbileacids
_version_	1718404729520783360

Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids

Ejemplares similares