Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress

Abstract Stress is a primary risk factor for psychiatric disorders. However, it is not fully understood why some stressed individuals are more vulnerable to psychiatric disorders than others. Here, we investigated whether multigenerational ancestral stress produces phenotypes that are sensitive to d...

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Autores principales:	Jamshid Faraji, Nabiollah Soltanpour, Hamid Lotfi, Reza Moeeini, Ali-Reza Moharreri, Shabnam Roudaki, S. Abedin Hosseini, David M. Olson, Ali-Akbar Abdollahi, Nasrin Soltanpour, Majid H. Mohajerani, Gerlinde A. S. Metz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f805a80f655f48479d2a2e9d740ac077
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spelling	oai:doaj.org-article:f805a80f655f48479d2a2e9d740ac0772021-12-02T12:32:01ZLack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress10.1038/s41598-017-05440-82045-2322https://doaj.org/article/f805a80f655f48479d2a2e9d740ac0772017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05440-8https://doaj.org/toc/2045-2322Abstract Stress is a primary risk factor for psychiatric disorders. However, it is not fully understood why some stressed individuals are more vulnerable to psychiatric disorders than others. Here, we investigated whether multigenerational ancestral stress produces phenotypes that are sensitive to depression-like symptoms in rats. We also examined whether social isolation reveals potentially latent sensitivity to depression-like behaviours. F4 female rats born to a lineage of stressed mothers (F0-F3) received stress in adulthood while housed in pairs or alone. Social isolation during stress induced cognitive and psychomotor retardation only in rats exposed to ancestral stress. Social isolation also hampered the resilience of the hypothalamic-pituitary-adrenal axis to chronic stress and reduced hippocampal volume and brain-derived neurotrophic factor (BDNF) expression. Thus, synergy between social isolation and stress may unmask a latent history of ancestral stress, and raises vulnerability to mental health conditions. The findings support the notion that social support critically promotes stress coping and resilience.Jamshid FarajiNabiollah SoltanpourHamid LotfiReza MoeeiniAli-Reza MoharreriShabnam RoudakiS. Abedin HosseiniDavid M. OlsonAli-Akbar AbdollahiNasrin SoltanpourMajid H. MohajeraniGerlinde A. S. MetzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jamshid Faraji Nabiollah Soltanpour Hamid Lotfi Reza Moeeini Ali-Reza Moharreri Shabnam Roudaki S. Abedin Hosseini David M. Olson Ali-Akbar Abdollahi Nasrin Soltanpour Majid H. Mohajerani Gerlinde A. S. Metz Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
description	Abstract Stress is a primary risk factor for psychiatric disorders. However, it is not fully understood why some stressed individuals are more vulnerable to psychiatric disorders than others. Here, we investigated whether multigenerational ancestral stress produces phenotypes that are sensitive to depression-like symptoms in rats. We also examined whether social isolation reveals potentially latent sensitivity to depression-like behaviours. F4 female rats born to a lineage of stressed mothers (F0-F3) received stress in adulthood while housed in pairs or alone. Social isolation during stress induced cognitive and psychomotor retardation only in rats exposed to ancestral stress. Social isolation also hampered the resilience of the hypothalamic-pituitary-adrenal axis to chronic stress and reduced hippocampal volume and brain-derived neurotrophic factor (BDNF) expression. Thus, synergy between social isolation and stress may unmask a latent history of ancestral stress, and raises vulnerability to mental health conditions. The findings support the notion that social support critically promotes stress coping and resilience.
format	article
author	Jamshid Faraji Nabiollah Soltanpour Hamid Lotfi Reza Moeeini Ali-Reza Moharreri Shabnam Roudaki S. Abedin Hosseini David M. Olson Ali-Akbar Abdollahi Nasrin Soltanpour Majid H. Mohajerani Gerlinde A. S. Metz
author_facet	Jamshid Faraji Nabiollah Soltanpour Hamid Lotfi Reza Moeeini Ali-Reza Moharreri Shabnam Roudaki S. Abedin Hosseini David M. Olson Ali-Akbar Abdollahi Nasrin Soltanpour Majid H. Mohajerani Gerlinde A. S. Metz
author_sort	Jamshid Faraji
title	Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
title_short	Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
title_full	Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
title_fullStr	Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
title_full_unstemmed	Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress
title_sort	lack of social support raises stress vulnerability in rats with a history of ancestral stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f805a80f655f48479d2a2e9d740ac077
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Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress

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