The New Era of Biologics in Atopic Dermatitis: A Review

Atopic dermatitis (AD) is a prevalent inflammatory skin disorder affecting all ages and ethnic groups. The age-dependent varying appearance and extent of pruritic lesions are accompanied by distinct individual suffering, highlighting the importance of effective treatment options. Over the past year...

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Autores principales:	Simon Schneider, Linda Li, Alexander Zink
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2021
Materias:	atopic dermatitis, therapy biological dupilumab Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/f807247e38bb471c8cfb27ac121f3b51
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spelling	oai:doaj.org-article:f807247e38bb471c8cfb27ac121f3b512021-11-15T15:16:19ZThe New Era of Biologics in Atopic Dermatitis: A Review10.5826/dpc.1104a1442160-9381https://doaj.org/article/f807247e38bb471c8cfb27ac121f3b512021-10-01T00:00:00Zhttps://dpcj.org/index.php/dpc/article/view/2120https://doaj.org/toc/2160-9381 Atopic dermatitis (AD) is a prevalent inflammatory skin disorder affecting all ages and ethnic groups. The age-dependent varying appearance and extent of pruritic lesions are accompanied by distinct individual suffering, highlighting the importance of effective treatment options. Over the past years, systemic drugs have considerably extended therapeutic approaches of patients with moderate to severe AD, in particular, new biologics, most notably dupilumab has appeared as major breakthrough. In addition to monoclonal blockade of IL-4 and IL-13 pathway, more cytokines have been found to play a substantial role in AD pathogenesis, presenting potential targets for new therapy options. Simon SchneiderLinda LiAlexander ZinkMattioli1885articleatopic dermatitis,therapybiologicaldupilumabDermatologyRL1-803ENDermatology Practical & Conceptual (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atopic dermatitis, therapy biological dupilumab Dermatology RL1-803
spellingShingle	atopic dermatitis, therapy biological dupilumab Dermatology RL1-803 Simon Schneider Linda Li Alexander Zink The New Era of Biologics in Atopic Dermatitis: A Review
description	Atopic dermatitis (AD) is a prevalent inflammatory skin disorder affecting all ages and ethnic groups. The age-dependent varying appearance and extent of pruritic lesions are accompanied by distinct individual suffering, highlighting the importance of effective treatment options. Over the past years, systemic drugs have considerably extended therapeutic approaches of patients with moderate to severe AD, in particular, new biologics, most notably dupilumab has appeared as major breakthrough. In addition to monoclonal blockade of IL-4 and IL-13 pathway, more cytokines have been found to play a substantial role in AD pathogenesis, presenting potential targets for new therapy options.
format	article
author	Simon Schneider Linda Li Alexander Zink
author_facet	Simon Schneider Linda Li Alexander Zink
author_sort	Simon Schneider
title	The New Era of Biologics in Atopic Dermatitis: A Review
title_short	The New Era of Biologics in Atopic Dermatitis: A Review
title_full	The New Era of Biologics in Atopic Dermatitis: A Review
title_fullStr	The New Era of Biologics in Atopic Dermatitis: A Review
title_full_unstemmed	The New Era of Biologics in Atopic Dermatitis: A Review
title_sort	new era of biologics in atopic dermatitis: a review
publisher	Mattioli1885
publishDate	2021
url	https://doaj.org/article/f807247e38bb471c8cfb27ac121f3b51
work_keys_str_mv	AT simonschneider theneweraofbiologicsinatopicdermatitisareview AT lindali theneweraofbiologicsinatopicdermatitisareview AT alexanderzink theneweraofbiologicsinatopicdermatitisareview AT simonschneider neweraofbiologicsinatopicdermatitisareview AT lindali neweraofbiologicsinatopicdermatitisareview AT alexanderzink neweraofbiologicsinatopicdermatitisareview
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The New Era of Biologics in Atopic Dermatitis: A Review

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