The chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals

The chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals

Abstract The chloride/phosphate ratio (Cl/PO4) has been suggested to have a role in primary hyperparathyroidism (PHPT), but the associations between Cl/PO4 combined with ALP level and PHPT has not been well-studied. Our aim was to investigate the predictive value of combination Cl/PO4 with ALP for P...

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Autores principales: Qianqian Wang, Xu Li, Haibing Chen, Haoyong Yu, Lianxi Li, Jun Yin, Jian Zhou, Ming Li, Qing Li, Junfeng Han, Li Wei, Fang Liu, Yuqian Bao, Weiping Jia
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/f80abe7f0d674403a0d1cf4491807181
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spelling oai:doaj.org-article:f80abe7f0d674403a0d1cf44918071812021-12-02T11:52:17ZThe chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals10.1038/s41598-017-05183-62045-2322https://doaj.org/article/f80abe7f0d674403a0d1cf44918071812017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05183-6https://doaj.org/toc/2045-2322Abstract The chloride/phosphate ratio (Cl/PO4) has been suggested to have a role in primary hyperparathyroidism (PHPT), but the associations between Cl/PO4 combined with ALP level and PHPT has not been well-studied. Our aim was to investigate the predictive value of combination Cl/PO4 with ALP for PHPT. A cross-sectional retrospective analysis was conducted to examine 172 patients diagnosed with PHPT categorized into two groups: normocalcaemic primary hyperparathyroidism (NPHPT) group and hypercalcaemia PHPT group. We found that Cl/PO4 levels and ALP levels in the NPHPT and hypercalcaemia PHPT group were both significantly higher than normal controls. Cl/PO4 and ALP levels were an independent risk factor for PHPT. Cl/PO4 combined with ALP increased the receiver-operating characteristic curves (ROC-AUC) and the diagnostic value in NPHPT and hypercalcaemia PHPT group (0.913; 95% CI, 0.744–1.000 and 0.932; 95% CI, 0.897–0.966, respectively), specificity of 92.8% and sensitivity of 98%. In conclusion, combination Cl/PO4 with ALP might be a low-cost, simple, available predictive marker of PHPT in Chinese individuals, particularly Chinese remote region where the method used to measure PTH cannot be done. Moreover, due to serum calcium level in NPHPT, Cl/PO4 combined with ALP level measurement have great potential to predict significant occurrence of NPHPT.Qianqian WangXu LiHaibing ChenHaoyong YuLianxi LiJun YinJian ZhouMing LiQing LiJunfeng HanLi WeiFang LiuYuqian BaoWeiping JiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Qianqian Wang
Xu Li
Haibing Chen
Haoyong Yu
Lianxi Li
Jun Yin
Jian Zhou
Ming Li
Qing Li
Junfeng Han
Li Wei
Fang Liu
Yuqian Bao
Weiping Jia
The chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals
description Abstract The chloride/phosphate ratio (Cl/PO4) has been suggested to have a role in primary hyperparathyroidism (PHPT), but the associations between Cl/PO4 combined with ALP level and PHPT has not been well-studied. Our aim was to investigate the predictive value of combination Cl/PO4 with ALP for PHPT. A cross-sectional retrospective analysis was conducted to examine 172 patients diagnosed with PHPT categorized into two groups: normocalcaemic primary hyperparathyroidism (NPHPT) group and hypercalcaemia PHPT group. We found that Cl/PO4 levels and ALP levels in the NPHPT and hypercalcaemia PHPT group were both significantly higher than normal controls. Cl/PO4 and ALP levels were an independent risk factor for PHPT. Cl/PO4 combined with ALP increased the receiver-operating characteristic curves (ROC-AUC) and the diagnostic value in NPHPT and hypercalcaemia PHPT group (0.913; 95% CI, 0.744–1.000 and 0.932; 95% CI, 0.897–0.966, respectively), specificity of 92.8% and sensitivity of 98%. In conclusion, combination Cl/PO4 with ALP might be a low-cost, simple, available predictive marker of PHPT in Chinese individuals, particularly Chinese remote region where the method used to measure PTH cannot be done. Moreover, due to serum calcium level in NPHPT, Cl/PO4 combined with ALP level measurement have great potential to predict significant occurrence of NPHPT.
format article
author Qianqian Wang
Xu Li
Haibing Chen
Haoyong Yu
Lianxi Li
Jun Yin
Jian Zhou
Ming Li
Qing Li
Junfeng Han
Li Wei
Fang Liu
Yuqian Bao
Weiping Jia
author_facet Qianqian Wang
Xu Li
Haibing Chen
Haoyong Yu
Lianxi Li
Jun Yin
Jian Zhou
Ming Li
Qing Li
Junfeng Han
Li Wei
Fang Liu
Yuqian Bao
Weiping Jia
author_sort Qianqian Wang
title The chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals
title_short The chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals
title_full The chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals
title_fullStr The chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals
title_full_unstemmed The chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals
title_sort chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in chinese individuals
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/f80abe7f0d674403a0d1cf4491807181
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