Is it possible to prevent chemotherapy-induced heart failure with cardiovascular drugs - the review of the current clinical evidence

Katarzyna Korzeniowska, Jerzy Jankowski, Artur Cieślewicz, Anna Jabłecka Department of Clinical Pharmacology, Poznan University of Medical Sciences, Poznan 61-848, PolandCorrespondence: Artur CieślewiczDepartment of Clinical Pharmacology, Poznan University of Medical Sciences, Długa 1/2 Str., Poznan...

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Autores principales: Korzeniowska K, Jankowski J, Cieślewicz A, Jabłecka A
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Lenguaje:EN
Publicado: Dove Medical Press 2019
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spelling oai:doaj.org-article:f80b7307cee940139e2c39ff4c6ac18d2021-12-02T10:51:31ZIs it possible to prevent chemotherapy-induced heart failure with cardiovascular drugs - the review of the current clinical evidence1178-203Xhttps://doaj.org/article/f80b7307cee940139e2c39ff4c6ac18d2019-09-01T00:00:00Zhttps://www.dovepress.com/is-it-possible-to-prevent-chemotherapy-induced-heart-failure-with-card-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203XKatarzyna Korzeniowska, Jerzy Jankowski, Artur Cieślewicz, Anna Jabłecka Department of Clinical Pharmacology, Poznan University of Medical Sciences, Poznan 61-848, PolandCorrespondence: Artur CieślewiczDepartment of Clinical Pharmacology, Poznan University of Medical Sciences, Długa 1/2 Str., Poznan 61-848, PolandTel +48 61 854 9216Fax +48 61 853 3161Email artcies@ump.edu.plAbstract: Cardiovascular diseases and cancer are the most common death causes in the USA and Europe. Moreover, many patients suffer from both of these conditions – a situation which may result from cardiotoxicity of anticancer treatment. In order to reduce the severity of this adverse effect, various methods have been proposed, including the usage of new drug forms and less toxic analogs, omitting the combinations of potentially cardiotoxic drugs and introducing potential cardioprotective agents to the therapy. However, prevention of cardiotoxicity still seems to be insufficient. The article reviews the results of current studies on the use of cardiovascular drugs in the prevention of cardiotoxicity. Based on this knowledge, the most promising cardioprotective drugs seem to be carvedilol, nebivolol, enalapril, and candesartan, as they prevent heart remodeling and correct elevated resting heart rate, which directly affects mortality. Alternatively, in case of adverse reactions, statins might be considered.Keywords: chemotherapy, cardiotoxicity, heart failure, preventionKorzeniowska KJankowski JCieślewicz AJabłecka ADove Medical Pressarticlechemotherapycardiotoxicityheart failurepreventionTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 15, Pp 1095-1110 (2019)
institution DOAJ
collection DOAJ
language EN
topic chemotherapy
cardiotoxicity
heart failure
prevention
Therapeutics. Pharmacology
RM1-950
spellingShingle chemotherapy
cardiotoxicity
heart failure
prevention
Therapeutics. Pharmacology
RM1-950
Korzeniowska K
Jankowski J
Cieślewicz A
Jabłecka A
Is it possible to prevent chemotherapy-induced heart failure with cardiovascular drugs - the review of the current clinical evidence
description Katarzyna Korzeniowska, Jerzy Jankowski, Artur Cieślewicz, Anna Jabłecka Department of Clinical Pharmacology, Poznan University of Medical Sciences, Poznan 61-848, PolandCorrespondence: Artur CieślewiczDepartment of Clinical Pharmacology, Poznan University of Medical Sciences, Długa 1/2 Str., Poznan 61-848, PolandTel +48 61 854 9216Fax +48 61 853 3161Email artcies@ump.edu.plAbstract: Cardiovascular diseases and cancer are the most common death causes in the USA and Europe. Moreover, many patients suffer from both of these conditions – a situation which may result from cardiotoxicity of anticancer treatment. In order to reduce the severity of this adverse effect, various methods have been proposed, including the usage of new drug forms and less toxic analogs, omitting the combinations of potentially cardiotoxic drugs and introducing potential cardioprotective agents to the therapy. However, prevention of cardiotoxicity still seems to be insufficient. The article reviews the results of current studies on the use of cardiovascular drugs in the prevention of cardiotoxicity. Based on this knowledge, the most promising cardioprotective drugs seem to be carvedilol, nebivolol, enalapril, and candesartan, as they prevent heart remodeling and correct elevated resting heart rate, which directly affects mortality. Alternatively, in case of adverse reactions, statins might be considered.Keywords: chemotherapy, cardiotoxicity, heart failure, prevention
format article
author Korzeniowska K
Jankowski J
Cieślewicz A
Jabłecka A
author_facet Korzeniowska K
Jankowski J
Cieślewicz A
Jabłecka A
author_sort Korzeniowska K
title Is it possible to prevent chemotherapy-induced heart failure with cardiovascular drugs - the review of the current clinical evidence
title_short Is it possible to prevent chemotherapy-induced heart failure with cardiovascular drugs - the review of the current clinical evidence
title_full Is it possible to prevent chemotherapy-induced heart failure with cardiovascular drugs - the review of the current clinical evidence
title_fullStr Is it possible to prevent chemotherapy-induced heart failure with cardiovascular drugs - the review of the current clinical evidence
title_full_unstemmed Is it possible to prevent chemotherapy-induced heart failure with cardiovascular drugs - the review of the current clinical evidence
title_sort is it possible to prevent chemotherapy-induced heart failure with cardiovascular drugs - the review of the current clinical evidence
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/f80b7307cee940139e2c39ff4c6ac18d
work_keys_str_mv AT korzeniowskak isitpossibletopreventchemotherapyinducedheartfailurewithcardiovasculardrugsthereviewofthecurrentclinicalevidence
AT jankowskij isitpossibletopreventchemotherapyinducedheartfailurewithcardiovasculardrugsthereviewofthecurrentclinicalevidence
AT cieslewicza isitpossibletopreventchemotherapyinducedheartfailurewithcardiovasculardrugsthereviewofthecurrentclinicalevidence
AT jabłeckaa isitpossibletopreventchemotherapyinducedheartfailurewithcardiovasculardrugsthereviewofthecurrentclinicalevidence
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