Melatonin and diabetes: from pathophysiology to the treatment perspectives

Pineal hormone melatonin synchronizes insulin secretion and glucose homeostasis with solar periods. Misalliance between melatonin-mediated circadian rhythms and insulin secretion characterizes diabetes mellitus type 1 (T1DM) and type 2 (T2DM). Insulin deficiency in T1DM is accompanied by increased m...

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Autores principales:	Vladimir Iosifovich Konenkov, Vadim Valerievich Klimontov, Svetlana Viktorovna Michurina, M A Prudnikova, I Ju Ishenko
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	diabetes melatonin circadian rhythms insulin epiphysis Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/f80c0ce67853430aa9b49c6c16d3126c
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spelling	oai:doaj.org-article:f80c0ce67853430aa9b49c6c16d3126c2021-11-14T09:00:18ZMelatonin and diabetes: from pathophysiology to the treatment perspectives2072-03512072-037810.14341/2072-0351-3751https://doaj.org/article/f80c0ce67853430aa9b49c6c16d3126c2013-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/3751https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Pineal hormone melatonin synchronizes insulin secretion and glucose homeostasis with solar periods. Misalliance between melatonin-mediated circadian rhythms and insulin secretion characterizes diabetes mellitus type 1 (T1DM) and type 2 (T2DM). Insulin deficiency in T1DM is accompanied by increased melatonin production. Conversely, T2DM is characterized by diminished melatonin secretion. In genome-wide association studies the variants of melatonin receptor MT2 gene (rs1387153 and rs10830963) were associated with fasting glucose, beta-cell function and T2DM. In experimental models of diabetes melatonin enhanced beta-cell proliferation and neogenesis, improved insulin resistance and alleviated oxidative stress in retina and kidneys. However, further investigation is required to assess the therapeutic value of melatonin in diabetic patients.Vladimir Iosifovich KonenkovVadim Valerievich KlimontovSvetlana Viktorovna MichurinaM A PrudnikovaI Ju IshenkoEndocrinology Research Centrearticlediabetesmelatonincircadian rhythmsinsulinepiphysisNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 2, Pp 11-16 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes melatonin circadian rhythms insulin epiphysis Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes melatonin circadian rhythms insulin epiphysis Nutritional diseases. Deficiency diseases RC620-627 Vladimir Iosifovich Konenkov Vadim Valerievich Klimontov Svetlana Viktorovna Michurina M A Prudnikova I Ju Ishenko Melatonin and diabetes: from pathophysiology to the treatment perspectives
description	Pineal hormone melatonin synchronizes insulin secretion and glucose homeostasis with solar periods. Misalliance between melatonin-mediated circadian rhythms and insulin secretion characterizes diabetes mellitus type 1 (T1DM) and type 2 (T2DM). Insulin deficiency in T1DM is accompanied by increased melatonin production. Conversely, T2DM is characterized by diminished melatonin secretion. In genome-wide association studies the variants of melatonin receptor MT2 gene (rs1387153 and rs10830963) were associated with fasting glucose, beta-cell function and T2DM. In experimental models of diabetes melatonin enhanced beta-cell proliferation and neogenesis, improved insulin resistance and alleviated oxidative stress in retina and kidneys. However, further investigation is required to assess the therapeutic value of melatonin in diabetic patients.
format	article
author	Vladimir Iosifovich Konenkov Vadim Valerievich Klimontov Svetlana Viktorovna Michurina M A Prudnikova I Ju Ishenko
author_facet	Vladimir Iosifovich Konenkov Vadim Valerievich Klimontov Svetlana Viktorovna Michurina M A Prudnikova I Ju Ishenko
author_sort	Vladimir Iosifovich Konenkov
title	Melatonin and diabetes: from pathophysiology to the treatment perspectives
title_short	Melatonin and diabetes: from pathophysiology to the treatment perspectives
title_full	Melatonin and diabetes: from pathophysiology to the treatment perspectives
title_fullStr	Melatonin and diabetes: from pathophysiology to the treatment perspectives
title_full_unstemmed	Melatonin and diabetes: from pathophysiology to the treatment perspectives
title_sort	melatonin and diabetes: from pathophysiology to the treatment perspectives
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/f80c0ce67853430aa9b49c6c16d3126c
work_keys_str_mv	AT vladimiriosifovichkonenkov melatoninanddiabetesfrompathophysiologytothetreatmentperspectives AT vadimvalerievichklimontov melatoninanddiabetesfrompathophysiologytothetreatmentperspectives AT svetlanaviktorovnamichurina melatoninanddiabetesfrompathophysiologytothetreatmentperspectives AT maprudnikova melatoninanddiabetesfrompathophysiologytothetreatmentperspectives AT ijuishenko melatoninanddiabetesfrompathophysiologytothetreatmentperspectives
_version_	1718429626030620672

Melatonin and diabetes: from pathophysiology to the treatment perspectives

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