Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N2O for recreational use: a case report

Dan Luo,* Jiajun Xu,* Li Hu, Liangming Yu, Leling Xie, Jing Li Department of Psychiatry, Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China *These authors contributed equally to this work Abstract: N2O, or laughing gas, is gener...

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Autores principales:	Luo D, Xu JJ, Hu L, Yu LM, Xie LL, Li J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	nitrous oxide recreational use cognitive dysfunction encephalatrophy hyperbaric oxygen therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f80d42c9ea6647d29ff51ef59345d732
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spelling	oai:doaj.org-article:f80d42c9ea6647d29ff51ef59345d7322021-12-02T09:05:04ZHyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N2O for recreational use: a case report1178-2021https://doaj.org/article/f80d42c9ea6647d29ff51ef59345d7322018-08-01T00:00:00Zhttps://www.dovepress.com/hyperbaric-oxygen-therapy-to-improve-cognitive-dysfunction-and-encepha-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Dan Luo,* Jiajun Xu,* Li Hu, Liangming Yu, Leling Xie, Jing Li Department of Psychiatry, Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China *These authors contributed equally to this work Abstract: N2O, or laughing gas, is generally used for anesthesia, especially in stomatology and pediatrics but is also commonly used recreationally. Cognitive dysfunction induced by the recreational use of N2O is rare. Here, we present the case of an 18-year-old female with a history of having used N2O recreationally for 5 months who suffered from encephalatrophy and severe cognitive dysfunction. All of the symptoms gradually subsided with ~20 days of treatment by hyperbaric oxygenation. We hypothesize that the long-term use of N2O may have induced a chronic state of systemic hypoxia that further induced cerebral atrophy with impaired cognitive function. Hyperbaric oxygen therapy (HBOT) is reported here for the first time as an important therapeutic element for treating N2O toxicity due to recreational use. Keywords: N2O, recreational use, cognitive dysfunction, encephalatrophy, hyperbaric oxygen therapyLuo DXu JJHu LYu LMXie LLLi JDove Medical Pressarticlenitrous oxiderecreational usecognitive dysfunctionencephalatrophyhyperbaric oxygen therapyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1963-1967 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	nitrous oxide recreational use cognitive dysfunction encephalatrophy hyperbaric oxygen therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	nitrous oxide recreational use cognitive dysfunction encephalatrophy hyperbaric oxygen therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Luo D Xu JJ Hu L Yu LM Xie LL Li J Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N2O for recreational use: a case report
description	Dan Luo,* Jiajun Xu,* Li Hu, Liangming Yu, Leling Xie, Jing Li Department of Psychiatry, Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China *These authors contributed equally to this work Abstract: N2O, or laughing gas, is generally used for anesthesia, especially in stomatology and pediatrics but is also commonly used recreationally. Cognitive dysfunction induced by the recreational use of N2O is rare. Here, we present the case of an 18-year-old female with a history of having used N2O recreationally for 5 months who suffered from encephalatrophy and severe cognitive dysfunction. All of the symptoms gradually subsided with ~20 days of treatment by hyperbaric oxygenation. We hypothesize that the long-term use of N2O may have induced a chronic state of systemic hypoxia that further induced cerebral atrophy with impaired cognitive function. Hyperbaric oxygen therapy (HBOT) is reported here for the first time as an important therapeutic element for treating N2O toxicity due to recreational use. Keywords: N2O, recreational use, cognitive dysfunction, encephalatrophy, hyperbaric oxygen therapy
format	article
author	Luo D Xu JJ Hu L Yu LM Xie LL Li J
author_facet	Luo D Xu JJ Hu L Yu LM Xie LL Li J
author_sort	Luo D
title	Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N2O for recreational use: a case report
title_short	Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N2O for recreational use: a case report
title_full	Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N2O for recreational use: a case report
title_fullStr	Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N2O for recreational use: a case report
title_full_unstemmed	Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N2O for recreational use: a case report
title_sort	hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by n2o for recreational use: a case report
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f80d42c9ea6647d29ff51ef59345d732
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Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by&nbsp;N2O for recreational use: a case report

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Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N2O for recreational use: a case report