Total Cerebral Small Vessel Disease Burden on MRI Correlates With Cognitive Impairment in Outpatients With Amnestic Disorders

Objectives: The main markers of cerebral small vessel disease (cSVD) on MRI may be entered into a scoring system, with the total score representing the overall burden of cSVD. An association between total cSVD score and cognitive dysfunction has been reported in several cohorts. The present study ai...

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Autores principales:	Yangyi Fan, Yicheng Xu, Ming Shen, Huailian Guo, Zhaoxu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cerebral small vessel disease brain magnetic resonance imaging cognitive impairment white matter hyperintensities enlarged perivascular spaces cerebral microbleed Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f80d9720db7546438a74380236961de6
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spelling	oai:doaj.org-article:f80d9720db7546438a74380236961de62021-12-02T11:32:24ZTotal Cerebral Small Vessel Disease Burden on MRI Correlates With Cognitive Impairment in Outpatients With Amnestic Disorders1664-229510.3389/fneur.2021.747115https://doaj.org/article/f80d9720db7546438a74380236961de62021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.747115/fullhttps://doaj.org/toc/1664-2295Objectives: The main markers of cerebral small vessel disease (cSVD) on MRI may be entered into a scoring system, with the total score representing the overall burden of cSVD. An association between total cSVD score and cognitive dysfunction has been reported in several cohorts. The present study aimed to investigate this association in outpatients with amnestic disorders.Materials and Methods: Outpatients with amnestic complaints in a memory clinic (n = 289) were recruited retrospectively. All the patients had undergone clinical and cognitive evaluation at first presentation. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA) scale. The total cSVD score was based on the following markers on MRI: lacune; white matter hyperintensities, microbleed, and enlarged perivascular spaces. The association between total cSVD score and MoCA score was tested via Spearman's analysis and a linear regression model.Results: Among the 289 patients, rates for 0–4 cSVD markers respectively ranged from 30.4 to 2.8%. A multiple linear regression model revealed an inverse correlation between the total cSVD score and MoCA score. The association remained significant after adjusting for gender, age, education, levels of medial temporal lobe atrophy, and classical vascular risk factors [β = −0.729, 95% CI (−1.244, −0.213); P = 0.006]. When individual markers were individually analyzed after adjusting for the same factors, only microbleed associated with MoCA score [β = −3.007, 95% CI (−4.533, −1.480), P < 0.001].Conclusions: A significant association was demonstrated between total cSVD score and cognitive performance in the outpatients with amnestic disorders.Yangyi FanYicheng XuMing ShenHuailian GuoZhaoxu ZhangFrontiers Media S.A.articlecerebral small vessel diseasebrain magnetic resonance imagingcognitive impairmentwhite matter hyperintensitiesenlarged perivascular spacescerebral microbleedNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebral small vessel disease brain magnetic resonance imaging cognitive impairment white matter hyperintensities enlarged perivascular spaces cerebral microbleed Neurology. Diseases of the nervous system RC346-429
spellingShingle	cerebral small vessel disease brain magnetic resonance imaging cognitive impairment white matter hyperintensities enlarged perivascular spaces cerebral microbleed Neurology. Diseases of the nervous system RC346-429 Yangyi Fan Yicheng Xu Ming Shen Huailian Guo Zhaoxu Zhang Total Cerebral Small Vessel Disease Burden on MRI Correlates With Cognitive Impairment in Outpatients With Amnestic Disorders
description	Objectives: The main markers of cerebral small vessel disease (cSVD) on MRI may be entered into a scoring system, with the total score representing the overall burden of cSVD. An association between total cSVD score and cognitive dysfunction has been reported in several cohorts. The present study aimed to investigate this association in outpatients with amnestic disorders.Materials and Methods: Outpatients with amnestic complaints in a memory clinic (n = 289) were recruited retrospectively. All the patients had undergone clinical and cognitive evaluation at first presentation. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA) scale. The total cSVD score was based on the following markers on MRI: lacune; white matter hyperintensities, microbleed, and enlarged perivascular spaces. The association between total cSVD score and MoCA score was tested via Spearman's analysis and a linear regression model.Results: Among the 289 patients, rates for 0–4 cSVD markers respectively ranged from 30.4 to 2.8%. A multiple linear regression model revealed an inverse correlation between the total cSVD score and MoCA score. The association remained significant after adjusting for gender, age, education, levels of medial temporal lobe atrophy, and classical vascular risk factors [β = −0.729, 95% CI (−1.244, −0.213); P = 0.006]. When individual markers were individually analyzed after adjusting for the same factors, only microbleed associated with MoCA score [β = −3.007, 95% CI (−4.533, −1.480), P < 0.001].Conclusions: A significant association was demonstrated between total cSVD score and cognitive performance in the outpatients with amnestic disorders.
format	article
author	Yangyi Fan Yicheng Xu Ming Shen Huailian Guo Zhaoxu Zhang
author_facet	Yangyi Fan Yicheng Xu Ming Shen Huailian Guo Zhaoxu Zhang
author_sort	Yangyi Fan
title	Total Cerebral Small Vessel Disease Burden on MRI Correlates With Cognitive Impairment in Outpatients With Amnestic Disorders
title_short	Total Cerebral Small Vessel Disease Burden on MRI Correlates With Cognitive Impairment in Outpatients With Amnestic Disorders
title_full	Total Cerebral Small Vessel Disease Burden on MRI Correlates With Cognitive Impairment in Outpatients With Amnestic Disorders
title_fullStr	Total Cerebral Small Vessel Disease Burden on MRI Correlates With Cognitive Impairment in Outpatients With Amnestic Disorders
title_full_unstemmed	Total Cerebral Small Vessel Disease Burden on MRI Correlates With Cognitive Impairment in Outpatients With Amnestic Disorders
title_sort	total cerebral small vessel disease burden on mri correlates with cognitive impairment in outpatients with amnestic disorders
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f80d9720db7546438a74380236961de6
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Total Cerebral Small Vessel Disease Burden on MRI Correlates With Cognitive Impairment in Outpatients With Amnestic Disorders

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