Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis

Osteoarthritis is caused by an imbalance between extracellular matrix synthesis and degradation. Here, the authors show that both strands of microRNA-455, -5p and -3p, target HIF2α and regulate cartilage homeostasis, and show that overexpression of these miRNAs is protective against osteoarthritis i...

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Autores principales:	Yoshiaki Ito, Tokio Matsuzaki, Fumiaki Ayabe, Sho Mokuda, Ryota Kurimoto, Takahide Matsushima, Yusuke Tabata, Maiko Inotsume, Hiroki Tsutsumi, Lin Liu, Masahiro Shinohara, Yoko Tanaka, Ryo Nakamichi, Keiichiro Nishida, Martin K. Lotz, Hiroshi Asahara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f8166b7edfce46f19f52746332d9254e
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spelling	oai:doaj.org-article:f8166b7edfce46f19f52746332d9254e2021-12-02T18:34:14ZBoth microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis10.1038/s41467-021-24460-72041-1723https://doaj.org/article/f8166b7edfce46f19f52746332d9254e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24460-7https://doaj.org/toc/2041-1723Osteoarthritis is caused by an imbalance between extracellular matrix synthesis and degradation. Here, the authors show that both strands of microRNA-455, -5p and -3p, target HIF2α and regulate cartilage homeostasis, and show that overexpression of these miRNAs is protective against osteoarthritis in mice.Yoshiaki ItoTokio MatsuzakiFumiaki AyabeSho MokudaRyota KurimotoTakahide MatsushimaYusuke TabataMaiko InotsumeHiroki TsutsumiLin LiuMasahiro ShinoharaYoko TanakaRyo NakamichiKeiichiro NishidaMartin K. LotzHiroshi AsaharaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoshiaki Ito Tokio Matsuzaki Fumiaki Ayabe Sho Mokuda Ryota Kurimoto Takahide Matsushima Yusuke Tabata Maiko Inotsume Hiroki Tsutsumi Lin Liu Masahiro Shinohara Yoko Tanaka Ryo Nakamichi Keiichiro Nishida Martin K. Lotz Hiroshi Asahara Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis
description	Osteoarthritis is caused by an imbalance between extracellular matrix synthesis and degradation. Here, the authors show that both strands of microRNA-455, -5p and -3p, target HIF2α and regulate cartilage homeostasis, and show that overexpression of these miRNAs is protective against osteoarthritis in mice.
format	article
author	Yoshiaki Ito Tokio Matsuzaki Fumiaki Ayabe Sho Mokuda Ryota Kurimoto Takahide Matsushima Yusuke Tabata Maiko Inotsume Hiroki Tsutsumi Lin Liu Masahiro Shinohara Yoko Tanaka Ryo Nakamichi Keiichiro Nishida Martin K. Lotz Hiroshi Asahara
author_facet	Yoshiaki Ito Tokio Matsuzaki Fumiaki Ayabe Sho Mokuda Ryota Kurimoto Takahide Matsushima Yusuke Tabata Maiko Inotsume Hiroki Tsutsumi Lin Liu Masahiro Shinohara Yoko Tanaka Ryo Nakamichi Keiichiro Nishida Martin K. Lotz Hiroshi Asahara
author_sort	Yoshiaki Ito
title	Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis
title_short	Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis
title_full	Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis
title_fullStr	Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis
title_full_unstemmed	Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis
title_sort	both microrna-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f8166b7edfce46f19f52746332d9254e
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Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis

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