Quantitative determination of glycosaminoglycans in tears of diabetic patients

Marilita M Moschos1, Alexandros A Rouvas1, Spyridon Papadimitriou1, Athanasios Kotsolis1, Nikolaos Sitaras2, Michael Apostolopoulos11Department of Ophthalmology; 2Department of Pharmacology, University of Athens, GreecePurpose: To determine the amount of glycosaminoglycans (GAGs) in tears of patient...

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Autores principales:	Marilita M Moschos, Alexandros A Rouvas, Spyridon Papadimitriou, Athanasios Kotsolis, Nikolaos Sitaras, Michael Apostolopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f8172df1ae0943068735c5b7142959ad
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spelling	oai:doaj.org-article:f8172df1ae0943068735c5b7142959ad2021-12-02T07:39:29ZQuantitative determination of glycosaminoglycans in tears of diabetic patients1177-54671177-5483https://doaj.org/article/f8172df1ae0943068735c5b7142959ad2008-10-01T00:00:00Zhttp://www.dovepress.com/quantitative-determination-of-glycosaminoglycans-in-tears-of-diabetic--a2364https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Marilita M Moschos1, Alexandros A Rouvas1, Spyridon Papadimitriou1, Athanasios Kotsolis1, Nikolaos Sitaras2, Michael Apostolopoulos11Department of Ophthalmology; 2Department of Pharmacology, University of Athens, GreecePurpose: To determine the amount of glycosaminoglycans (GAGs) in tears of patients with diabetic retinopathy (DR) and to compare it with normal subjects.Methods: 38 patients with DR and 24 normal volunteers were included. Thirty subjects suffered from background diabetic retinopathy (BDR) and 8 from proliferate diabetic retinopathy (PDR). For the GAGs assay, the uronic carbazole reaction was used.Results: The mean concentration of GAGs was significantly higher in patients with DR than in normal subjects. The GAGs concentration in patients with BDR or PDR was significantly higher than in normal subjects.Conclusion: The measurement of GAGs in tears of diabetic patients could be a tool in order to assess the stability or not of the disease.Keywords: glycosaminoglycans, tears, diabetic retinopathy Marilita M MoschosAlexandros A RouvasSpyridon PapadimitriouAthanasios KotsolisNikolaos SitarasMichael ApostolopoulosDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 3, Pp 581-584 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Marilita M Moschos Alexandros A Rouvas Spyridon Papadimitriou Athanasios Kotsolis Nikolaos Sitaras Michael Apostolopoulos Quantitative determination of glycosaminoglycans in tears of diabetic patients
description	Marilita M Moschos1, Alexandros A Rouvas1, Spyridon Papadimitriou1, Athanasios Kotsolis1, Nikolaos Sitaras2, Michael Apostolopoulos11Department of Ophthalmology; 2Department of Pharmacology, University of Athens, GreecePurpose: To determine the amount of glycosaminoglycans (GAGs) in tears of patients with diabetic retinopathy (DR) and to compare it with normal subjects.Methods: 38 patients with DR and 24 normal volunteers were included. Thirty subjects suffered from background diabetic retinopathy (BDR) and 8 from proliferate diabetic retinopathy (PDR). For the GAGs assay, the uronic carbazole reaction was used.Results: The mean concentration of GAGs was significantly higher in patients with DR than in normal subjects. The GAGs concentration in patients with BDR or PDR was significantly higher than in normal subjects.Conclusion: The measurement of GAGs in tears of diabetic patients could be a tool in order to assess the stability or not of the disease.Keywords: glycosaminoglycans, tears, diabetic retinopathy
format	article
author	Marilita M Moschos Alexandros A Rouvas Spyridon Papadimitriou Athanasios Kotsolis Nikolaos Sitaras Michael Apostolopoulos
author_facet	Marilita M Moschos Alexandros A Rouvas Spyridon Papadimitriou Athanasios Kotsolis Nikolaos Sitaras Michael Apostolopoulos
author_sort	Marilita M Moschos
title	Quantitative determination of glycosaminoglycans in tears of diabetic patients
title_short	Quantitative determination of glycosaminoglycans in tears of diabetic patients
title_full	Quantitative determination of glycosaminoglycans in tears of diabetic patients
title_fullStr	Quantitative determination of glycosaminoglycans in tears of diabetic patients
title_full_unstemmed	Quantitative determination of glycosaminoglycans in tears of diabetic patients
title_sort	quantitative determination of glycosaminoglycans in tears of diabetic patients
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/f8172df1ae0943068735c5b7142959ad
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Quantitative determination of glycosaminoglycans in tears of diabetic patients

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