An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites

Muscle degeneration: RNA structures as modulator of muscle function Transcriptional and post-transcriptional regulation of gene expression has a fundamental role in shaping the protein landscape. In skeletal muscles, the RNA landscape plays an important role in muscle function in both health and dis...

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Autores principales:	Tooba Abbassi-Daloii, Soheil Yousefi, Eleonora de Klerk, Laurens Grossouw, Muhammad Riaz, Peter A. C. ’t Hoen, Vered Raz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/f81d49d188ae4f5e9ff99d5513a56155
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spelling	oai:doaj.org-article:f81d49d188ae4f5e9ff99d5513a561552021-12-02T16:05:43ZAn alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites10.1038/s41514-017-0007-x2056-3973https://doaj.org/article/f81d49d188ae4f5e9ff99d5513a561552017-04-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0007-xhttps://doaj.org/toc/2056-3973Muscle degeneration: RNA structures as modulator of muscle function Transcriptional and post-transcriptional regulation of gene expression has a fundamental role in shaping the protein landscape. In skeletal muscles, the RNA landscape plays an important role in muscle function in both health and disease conditions. PABPN1 is a key regulator of mRNA processing in a late-onset muscular dystrophy and in aging. Here, the authors demonstrate that a decrease in PABPN1 function results in genome-wide alterations in mRNA structures. Reduced PABPN1 function alters both mRNA levels and RNA structures leading to altered protein sequences. Importantly, among the affected genes are muscle function regulators. Together, this study calls for a better understanding of alterations in RNA structures in disease and aging.Tooba Abbassi-DaloiiSoheil YousefiEleonora de KlerkLaurens GrossouwMuhammad RiazPeter A. C. ’t HoenVered RazNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Tooba Abbassi-Daloii Soheil Yousefi Eleonora de Klerk Laurens Grossouw Muhammad Riaz Peter A. C. ’t Hoen Vered Raz An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites
description	Muscle degeneration: RNA structures as modulator of muscle function Transcriptional and post-transcriptional regulation of gene expression has a fundamental role in shaping the protein landscape. In skeletal muscles, the RNA landscape plays an important role in muscle function in both health and disease conditions. PABPN1 is a key regulator of mRNA processing in a late-onset muscular dystrophy and in aging. Here, the authors demonstrate that a decrease in PABPN1 function results in genome-wide alterations in mRNA structures. Reduced PABPN1 function alters both mRNA levels and RNA structures leading to altered protein sequences. Importantly, among the affected genes are muscle function regulators. Together, this study calls for a better understanding of alterations in RNA structures in disease and aging.
format	article
author	Tooba Abbassi-Daloii Soheil Yousefi Eleonora de Klerk Laurens Grossouw Muhammad Riaz Peter A. C. ’t Hoen Vered Raz
author_facet	Tooba Abbassi-Daloii Soheil Yousefi Eleonora de Klerk Laurens Grossouw Muhammad Riaz Peter A. C. ’t Hoen Vered Raz
author_sort	Tooba Abbassi-Daloii
title	An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites
title_short	An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites
title_full	An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites
title_fullStr	An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites
title_full_unstemmed	An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites
title_sort	alanine expanded pabpn1 causes increased utilization of intronic polyadenylation sites
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f81d49d188ae4f5e9ff99d5513a56155
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An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites

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