SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Lung cancers often harbour loss-of-function mutations inSMARCA4. Here, the authors demonstrate a vulnerability of SMARCA4-deficient lung cancers for Aurora kinase A inhibition associated with mitotic defects.

Guardado en:

Detalles Bibliográficos
Autores principales:	Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A. Brekken, Bruce A. Posner, Michael Peyton, Luc Girard, TaeHyun Hwang, David A. Wheeler, John D. Minna, Michael A. White, Adi F. Gazdar, Michael G. Roth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f81ec3448b26422b8d9847f84e7abb5c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f81ec3448b26422b8d9847f84e7abb5c
record_format	dspace
spelling	oai:doaj.org-article:f81ec3448b26422b8d9847f84e7abb5c2021-12-02T14:40:24ZSMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers10.1038/ncomms140982041-1723https://doaj.org/article/f81ec3448b26422b8d9847f84e7abb5c2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14098https://doaj.org/toc/2041-1723Lung cancers often harbour loss-of-function mutations inSMARCA4. Here, the authors demonstrate a vulnerability of SMARCA4-deficient lung cancers for Aurora kinase A inhibition associated with mitotic defects.Vural TagalShuguang WeiWei ZhangRolf A. BrekkenBruce A. PosnerMichael PeytonLuc GirardTaeHyun HwangDavid A. WheelerJohn D. MinnaMichael A. WhiteAdi F. GazdarMichael G. RothNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vural Tagal Shuguang Wei Wei Zhang Rolf A. Brekken Bruce A. Posner Michael Peyton Luc Girard TaeHyun Hwang David A. Wheeler John D. Minna Michael A. White Adi F. Gazdar Michael G. Roth SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers
description	Lung cancers often harbour loss-of-function mutations inSMARCA4. Here, the authors demonstrate a vulnerability of SMARCA4-deficient lung cancers for Aurora kinase A inhibition associated with mitotic defects.
format	article
author	Vural Tagal Shuguang Wei Wei Zhang Rolf A. Brekken Bruce A. Posner Michael Peyton Luc Girard TaeHyun Hwang David A. Wheeler John D. Minna Michael A. White Adi F. Gazdar Michael G. Roth
author_facet	Vural Tagal Shuguang Wei Wei Zhang Rolf A. Brekken Bruce A. Posner Michael Peyton Luc Girard TaeHyun Hwang David A. Wheeler John D. Minna Michael A. White Adi F. Gazdar Michael G. Roth
author_sort	Vural Tagal
title	SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers
title_short	SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers
title_full	SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers
title_fullStr	SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers
title_full_unstemmed	SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers
title_sort	smarca4-inactivating mutations increase sensitivity to aurora kinase a inhibitor vx-680 in non-small cell lung cancers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f81ec3448b26422b8d9847f84e7abb5c
work_keys_str_mv	AT vuraltagal smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT shuguangwei smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT weizhang smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT rolfabrekken smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT bruceaposner smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT michaelpeyton smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT lucgirard smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT taehyunhwang smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT davidawheeler smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT johndminna smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT michaelawhite smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT adifgazdar smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers AT michaelgroth smarca4inactivatingmutationsincreasesensitivitytoaurorakinaseainhibitorvx680innonsmallcelllungcancers
_version_	1718390334088544256

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Ejemplares similares