Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI

Abstract The incidence of in-hospital cardiovascular adverse events (AEs) in patients with ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI) is relatively high. Identification of metabolic markers could improve our understanding of the unde...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaoyu Du, Hongzhao You, Yulin Li, Yuan Wang, Peng Hui, Bokang Qiao, Jie Lu, Weihua Zhang, Shanshan Zhou, Yang Zheng, Jie Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	ST-segment Elevation Myocardial Infarction (STEMI) Branched-chain Amino Acids (BCAA) BCAA Concentrations Primary Percutaneous Coronary Intervention (PCI) Global Registry Of Acute Coronary Events (GRACE) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f81ee9bef2194dffa39ce6fdf0dfd597
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f81ee9bef2194dffa39ce6fdf0dfd597
record_format	dspace
spelling	oai:doaj.org-article:f81ee9bef2194dffa39ce6fdf0dfd5972021-12-02T11:41:24ZRelationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI10.1038/s41598-018-34245-62045-2322https://doaj.org/article/f81ee9bef2194dffa39ce6fdf0dfd5972018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34245-6https://doaj.org/toc/2045-2322Abstract The incidence of in-hospital cardiovascular adverse events (AEs) in patients with ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI) is relatively high. Identification of metabolic markers could improve our understanding of the underlying pathological changes in these patients. We aimed to identify associations between concentrations of plasma metabolites on admission and development of in-hospital AEs in post-PCI patients with STEMI. We used targeted mass spectrometry to measure plasma concentrations of 26 amino acid metabolites on admission in 96 patients with STEMI who subsequently developed post-PCI AEs and in 96 age- and sex-matched patients without post-PCI cardiovascular AEs. Principal component analysis (PCA) revealed that PCA-derived factors, including branched chain amino acids (BCAAs), were associated with increased risks of all three pre-specified outcomes: cardiovascular mortality/acute heart failure (AHF), cardiovascular mortality, and AHF. Addition of BCAA to the Global Registry of Acute Coronary Events risk score increased the concordance C statistic from 0.702 to 0.814 (p < 0.001), and had a net reclassification index of 0.729 (95% confidence interval, 0.466–0.992, p < 0.001). These findings demonstrate that high circulating BCAA concentrations on admission are associated with subsequent in-hospital AEs after revascularization in patients with STEMI.Xiaoyu DuHongzhao YouYulin LiYuan WangPeng HuiBokang QiaoJie LuWeihua ZhangShanshan ZhouYang ZhengJie DuNature PortfolioarticleST-segment Elevation Myocardial Infarction (STEMI)Branched-chain Amino Acids (BCAA)BCAA ConcentrationsPrimary Percutaneous Coronary Intervention (PCI)Global Registry Of Acute Coronary Events (GRACE)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ST-segment Elevation Myocardial Infarction (STEMI) Branched-chain Amino Acids (BCAA) BCAA Concentrations Primary Percutaneous Coronary Intervention (PCI) Global Registry Of Acute Coronary Events (GRACE) Medicine R Science Q
spellingShingle	ST-segment Elevation Myocardial Infarction (STEMI) Branched-chain Amino Acids (BCAA) BCAA Concentrations Primary Percutaneous Coronary Intervention (PCI) Global Registry Of Acute Coronary Events (GRACE) Medicine R Science Q Xiaoyu Du Hongzhao You Yulin Li Yuan Wang Peng Hui Bokang Qiao Jie Lu Weihua Zhang Shanshan Zhou Yang Zheng Jie Du Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI
description	Abstract The incidence of in-hospital cardiovascular adverse events (AEs) in patients with ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI) is relatively high. Identification of metabolic markers could improve our understanding of the underlying pathological changes in these patients. We aimed to identify associations between concentrations of plasma metabolites on admission and development of in-hospital AEs in post-PCI patients with STEMI. We used targeted mass spectrometry to measure plasma concentrations of 26 amino acid metabolites on admission in 96 patients with STEMI who subsequently developed post-PCI AEs and in 96 age- and sex-matched patients without post-PCI cardiovascular AEs. Principal component analysis (PCA) revealed that PCA-derived factors, including branched chain amino acids (BCAAs), were associated with increased risks of all three pre-specified outcomes: cardiovascular mortality/acute heart failure (AHF), cardiovascular mortality, and AHF. Addition of BCAA to the Global Registry of Acute Coronary Events risk score increased the concordance C statistic from 0.702 to 0.814 (p < 0.001), and had a net reclassification index of 0.729 (95% confidence interval, 0.466–0.992, p < 0.001). These findings demonstrate that high circulating BCAA concentrations on admission are associated with subsequent in-hospital AEs after revascularization in patients with STEMI.
format	article
author	Xiaoyu Du Hongzhao You Yulin Li Yuan Wang Peng Hui Bokang Qiao Jie Lu Weihua Zhang Shanshan Zhou Yang Zheng Jie Du
author_facet	Xiaoyu Du Hongzhao You Yulin Li Yuan Wang Peng Hui Bokang Qiao Jie Lu Weihua Zhang Shanshan Zhou Yang Zheng Jie Du
author_sort	Xiaoyu Du
title	Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI
title_short	Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI
title_full	Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI
title_fullStr	Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI
title_full_unstemmed	Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI
title_sort	relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with stemi treated with pci
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f81ee9bef2194dffa39ce6fdf0dfd597
work_keys_str_mv	AT xiaoyudu relationshipsbetweencirculatingbranchedchainaminoacidconcentrationsandriskofadversecardiovasculareventsinpatientswithstemitreatedwithpci AT hongzhaoyou relationshipsbetweencirculatingbranchedchainaminoacidconcentrationsandriskofadversecardiovasculareventsinpatientswithstemitreatedwithpci AT yulinli relationshipsbetweencirculatingbranchedchainaminoacidconcentrationsandriskofadversecardiovasculareventsinpatientswithstemitreatedwithpci AT yuanwang relationshipsbetweencirculatingbranchedchainaminoacidconcentrationsandriskofadversecardiovasculareventsinpatientswithstemitreatedwithpci AT penghui relationshipsbetweencirculatingbranchedchainaminoacidconcentrationsandriskofadversecardiovasculareventsinpatientswithstemitreatedwithpci AT bokangqiao relationshipsbetweencirculatingbranchedchainaminoacidconcentrationsandriskofadversecardiovasculareventsinpatientswithstemitreatedwithpci AT jielu relationshipsbetweencirculatingbranchedchainaminoacidconcentrationsandriskofadversecardiovasculareventsinpatientswithstemitreatedwithpci AT weihuazhang relationshipsbetweencirculatingbranchedchainaminoacidconcentrationsandriskofadversecardiovasculareventsinpatientswithstemitreatedwithpci AT shanshanzhou relationshipsbetweencirculatingbranchedchainaminoacidconcentrationsandriskofadversecardiovasculareventsinpatientswithstemitreatedwithpci AT yangzheng relationshipsbetweencirculatingbranchedchainaminoacidconcentrationsandriskofadversecardiovasculareventsinpatientswithstemitreatedwithpci AT jiedu relationshipsbetweencirculatingbranchedchainaminoacidconcentrationsandriskofadversecardiovasculareventsinpatientswithstemitreatedwithpci
_version_	1718395438486257664

Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI

Ejemplares similares