Chronobiology and Metabolism: Is Ketogenic Diet Able to Influence Circadian Rhythm?

Circadian rhythms underpin most physiological processes, including energy metabolism. The core circadian clock consists of a transcription-translation negative feedback loop, and is synchronized to light-dark cycles by virtue of light input from the retina, to the central clock in the suprachiasmati...

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Autores principales:	Elena Gangitano, Lucio Gnessi, Andrea Lenzi, David Ray
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	chronobiology circadian rhythm circadian misalignment metabolism ketogenic diet (KD) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f81f13e9f7ff4e9384c7a4131c9e86d0
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id	oai:doaj.org-article:f81f13e9f7ff4e9384c7a4131c9e86d0
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spelling	oai:doaj.org-article:f81f13e9f7ff4e9384c7a4131c9e86d02021-11-08T05:47:31ZChronobiology and Metabolism: Is Ketogenic Diet Able to Influence Circadian Rhythm?1662-453X10.3389/fnins.2021.756970https://doaj.org/article/f81f13e9f7ff4e9384c7a4131c9e86d02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.756970/fullhttps://doaj.org/toc/1662-453XCircadian rhythms underpin most physiological processes, including energy metabolism. The core circadian clock consists of a transcription-translation negative feedback loop, and is synchronized to light-dark cycles by virtue of light input from the retina, to the central clock in the suprachiasmatic nucleus in the hypothalamus. All cells in the body have circadian oscillators which are entrained to the central clock by neural and humoral signals. In addition to light entrainment of the central clock in the brain, it now emerges that other stimuli can drive circadian clock function in peripheral tissues, the major one being food. This can then drive the liver clock to be misaligned with the central brain clock, a situation of internal misalignment with metabolic disease consequences. Such misalignment is prevalent, with shift workers making up 20% of the working population. The effects of diet composition on the clock are not completely clarified yet. High-fat diet and fasting influence circadian expression of clock genes, inducing phase-advance and phase-delay in animal models. Ketogenic diet (KD) is able to induce a metabolic switch from carbohydrate to fatty acid oxidation, miming a fasting state. In recent years, some animal studies have been conducted to investigate the ability of the KD to modify circadian gene expression, and demonstrated that the KD alters circadian rhythm and induces a rearrangement of metabolic gene expression. These findings may lead to new approaches to obesity and metabolic pathologies treatment.Elena GangitanoElena GangitanoLucio GnessiAndrea LenziDavid RayDavid RayFrontiers Media S.A.articlechronobiologycircadian rhythmcircadian misalignmentmetabolismketogenic diet (KD)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronobiology circadian rhythm circadian misalignment metabolism ketogenic diet (KD) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	chronobiology circadian rhythm circadian misalignment metabolism ketogenic diet (KD) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Elena Gangitano Elena Gangitano Lucio Gnessi Andrea Lenzi David Ray David Ray Chronobiology and Metabolism: Is Ketogenic Diet Able to Influence Circadian Rhythm?
description	Circadian rhythms underpin most physiological processes, including energy metabolism. The core circadian clock consists of a transcription-translation negative feedback loop, and is synchronized to light-dark cycles by virtue of light input from the retina, to the central clock in the suprachiasmatic nucleus in the hypothalamus. All cells in the body have circadian oscillators which are entrained to the central clock by neural and humoral signals. In addition to light entrainment of the central clock in the brain, it now emerges that other stimuli can drive circadian clock function in peripheral tissues, the major one being food. This can then drive the liver clock to be misaligned with the central brain clock, a situation of internal misalignment with metabolic disease consequences. Such misalignment is prevalent, with shift workers making up 20% of the working population. The effects of diet composition on the clock are not completely clarified yet. High-fat diet and fasting influence circadian expression of clock genes, inducing phase-advance and phase-delay in animal models. Ketogenic diet (KD) is able to induce a metabolic switch from carbohydrate to fatty acid oxidation, miming a fasting state. In recent years, some animal studies have been conducted to investigate the ability of the KD to modify circadian gene expression, and demonstrated that the KD alters circadian rhythm and induces a rearrangement of metabolic gene expression. These findings may lead to new approaches to obesity and metabolic pathologies treatment.
format	article
author	Elena Gangitano Elena Gangitano Lucio Gnessi Andrea Lenzi David Ray David Ray
author_facet	Elena Gangitano Elena Gangitano Lucio Gnessi Andrea Lenzi David Ray David Ray
author_sort	Elena Gangitano
title	Chronobiology and Metabolism: Is Ketogenic Diet Able to Influence Circadian Rhythm?
title_short	Chronobiology and Metabolism: Is Ketogenic Diet Able to Influence Circadian Rhythm?
title_full	Chronobiology and Metabolism: Is Ketogenic Diet Able to Influence Circadian Rhythm?
title_fullStr	Chronobiology and Metabolism: Is Ketogenic Diet Able to Influence Circadian Rhythm?
title_full_unstemmed	Chronobiology and Metabolism: Is Ketogenic Diet Able to Influence Circadian Rhythm?
title_sort	chronobiology and metabolism: is ketogenic diet able to influence circadian rhythm?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f81f13e9f7ff4e9384c7a4131c9e86d0
work_keys_str_mv	AT elenagangitano chronobiologyandmetabolismisketogenicdietabletoinfluencecircadianrhythm AT elenagangitano chronobiologyandmetabolismisketogenicdietabletoinfluencecircadianrhythm AT luciognessi chronobiologyandmetabolismisketogenicdietabletoinfluencecircadianrhythm AT andrealenzi chronobiologyandmetabolismisketogenicdietabletoinfluencecircadianrhythm AT davidray chronobiologyandmetabolismisketogenicdietabletoinfluencecircadianrhythm AT davidray chronobiologyandmetabolismisketogenicdietabletoinfluencecircadianrhythm
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Chronobiology and Metabolism: Is Ketogenic Diet Able to Influence Circadian Rhythm?

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