A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence

Abstract Cardiovascular and respiratory systems are anatomically and functionally linked; inspiration produces negative intrathoracic pressures that act on the heart and alter cardiac function. Inspiratory pressures increase with heart failure and can exceed the magnitude of ventricular pressure dur...

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Autores principales:	Leslie M. Ogilvie, Brittany A. Edgett, Simon Gray, Sally Al-Mufty, Jason S. Huber, Keith R. Brunt, Jeremy A. Simpson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f81faecfe49a4d2abbd96c1e0fd01c05
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spelling	oai:doaj.org-article:f81faecfe49a4d2abbd96c1e0fd01c052021-12-02T15:09:23ZA new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence10.1038/s41598-021-96050-y2045-2322https://doaj.org/article/f81faecfe49a4d2abbd96c1e0fd01c052021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96050-yhttps://doaj.org/toc/2045-2322Abstract Cardiovascular and respiratory systems are anatomically and functionally linked; inspiration produces negative intrathoracic pressures that act on the heart and alter cardiac function. Inspiratory pressures increase with heart failure and can exceed the magnitude of ventricular pressure during diastole. Accordingly, respiratory pressures may be a confounding factor to assessing cardiac function. While the interaction between respiration and the heart is well characterized, the extent to which systolic and diastolic indices are affected by inspiration is unknown. Our objective was to understand how inspiratory pressure affects the hemodynamic assessment of cardiac function. To do this, we developed custom software to assess and separate indices of systolic and diastolic function into inspiratory, early expiratory, and late expiratory phases of respiration. We then compared cardiac parameters during normal breathing and with various respiratory loads. Variations in inspiratory pressure had a small impact on systolic pressure and function. Conversely, diastolic pressure strongly correlated with negative inspiratory pressure. Cardiac pressures were less affected by respiration during expiration; late expiration was the most stable respiratory phase. In conclusion, inspiration is a large confounding influence on diastolic pressure, but minimally affects systolic pressure. Performing cardiac hemodynamic analysis by accounting for respiratory phase yields more accuracy and analytic confidence to the assessment of diastolic function.Leslie M. OgilvieBrittany A. EdgettSimon GraySally Al-MuftyJason S. HuberKeith R. BruntJeremy A. SimpsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leslie M. Ogilvie Brittany A. Edgett Simon Gray Sally Al-Mufty Jason S. Huber Keith R. Brunt Jeremy A. Simpson A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence
description	Abstract Cardiovascular and respiratory systems are anatomically and functionally linked; inspiration produces negative intrathoracic pressures that act on the heart and alter cardiac function. Inspiratory pressures increase with heart failure and can exceed the magnitude of ventricular pressure during diastole. Accordingly, respiratory pressures may be a confounding factor to assessing cardiac function. While the interaction between respiration and the heart is well characterized, the extent to which systolic and diastolic indices are affected by inspiration is unknown. Our objective was to understand how inspiratory pressure affects the hemodynamic assessment of cardiac function. To do this, we developed custom software to assess and separate indices of systolic and diastolic function into inspiratory, early expiratory, and late expiratory phases of respiration. We then compared cardiac parameters during normal breathing and with various respiratory loads. Variations in inspiratory pressure had a small impact on systolic pressure and function. Conversely, diastolic pressure strongly correlated with negative inspiratory pressure. Cardiac pressures were less affected by respiration during expiration; late expiration was the most stable respiratory phase. In conclusion, inspiration is a large confounding influence on diastolic pressure, but minimally affects systolic pressure. Performing cardiac hemodynamic analysis by accounting for respiratory phase yields more accuracy and analytic confidence to the assessment of diastolic function.
format	article
author	Leslie M. Ogilvie Brittany A. Edgett Simon Gray Sally Al-Mufty Jason S. Huber Keith R. Brunt Jeremy A. Simpson
author_facet	Leslie M. Ogilvie Brittany A. Edgett Simon Gray Sally Al-Mufty Jason S. Huber Keith R. Brunt Jeremy A. Simpson
author_sort	Leslie M. Ogilvie
title	A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence
title_short	A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence
title_full	A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence
title_fullStr	A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence
title_full_unstemmed	A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence
title_sort	new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f81faecfe49a4d2abbd96c1e0fd01c05
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A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence

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