Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery

Pancreatic cancer, the seventh most lethal cancer around the world, is considered complicated cancer due to poor prognosis and difficulty in treatment. Despite all the conventional treatments, including surgical therapy and chemotherapy, the mortality rate is still high. Therefore, the possibility o...

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Autores principales:	Ahyeon Kim, Jiwon Ha, Jeongeun Kim, Yongmin Cho, Jimyung Ahn, Chunhoo Cheon, Sung-Hoon Kim, Seong-Gyu Ko, Bonglee Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pancreatic cancer natural product traditional medicine apoptosis angiogenesis metastasis Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/f82007ab66d0434ebe69e18df53045c0
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spelling	oai:doaj.org-article:f82007ab66d0434ebe69e18df53045c02021-11-25T18:34:12ZNatural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery10.3390/nu131138012072-6643https://doaj.org/article/f82007ab66d0434ebe69e18df53045c02021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3801https://doaj.org/toc/2072-6643Pancreatic cancer, the seventh most lethal cancer around the world, is considered complicated cancer due to poor prognosis and difficulty in treatment. Despite all the conventional treatments, including surgical therapy and chemotherapy, the mortality rate is still high. Therefore, the possibility of using natural products for pancreatic cancer is increasing. In this study, 68 natural products that have anti-pancreatic cancer effects reported within five years were reviewed. The mechanisms of anti-cancer effects were divided into four types: apoptosis, anti-metastasis, anti-angiogenesis, and anti-resistance. Most of the studies were conducted for natural products that induce apoptosis in pancreatic cancer. Among them, plant extracts such as <i>Eucalyptus microcorys</i> account for the major portion. Some natural products, including <i>Moringa</i>, Coix seed, etc., showed multi-functional properties. Natural products could be beneficial candidates for treating pancreatic cancer.Ahyeon KimJiwon HaJeongeun KimYongmin ChoJimyung AhnChunhoo CheonSung-Hoon KimSeong-Gyu KoBonglee KimMDPI AGarticlepancreatic cancernatural producttraditional medicineapoptosisangiogenesismetastasisNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3801, p 3801 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancreatic cancer natural product traditional medicine apoptosis angiogenesis metastasis Nutrition. Foods and food supply TX341-641
spellingShingle	pancreatic cancer natural product traditional medicine apoptosis angiogenesis metastasis Nutrition. Foods and food supply TX341-641 Ahyeon Kim Jiwon Ha Jeongeun Kim Yongmin Cho Jimyung Ahn Chunhoo Cheon Sung-Hoon Kim Seong-Gyu Ko Bonglee Kim Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery
description	Pancreatic cancer, the seventh most lethal cancer around the world, is considered complicated cancer due to poor prognosis and difficulty in treatment. Despite all the conventional treatments, including surgical therapy and chemotherapy, the mortality rate is still high. Therefore, the possibility of using natural products for pancreatic cancer is increasing. In this study, 68 natural products that have anti-pancreatic cancer effects reported within five years were reviewed. The mechanisms of anti-cancer effects were divided into four types: apoptosis, anti-metastasis, anti-angiogenesis, and anti-resistance. Most of the studies were conducted for natural products that induce apoptosis in pancreatic cancer. Among them, plant extracts such as <i>Eucalyptus microcorys</i> account for the major portion. Some natural products, including <i>Moringa</i>, Coix seed, etc., showed multi-functional properties. Natural products could be beneficial candidates for treating pancreatic cancer.
format	article
author	Ahyeon Kim Jiwon Ha Jeongeun Kim Yongmin Cho Jimyung Ahn Chunhoo Cheon Sung-Hoon Kim Seong-Gyu Ko Bonglee Kim
author_facet	Ahyeon Kim Jiwon Ha Jeongeun Kim Yongmin Cho Jimyung Ahn Chunhoo Cheon Sung-Hoon Kim Seong-Gyu Ko Bonglee Kim
author_sort	Ahyeon Kim
title	Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery
title_short	Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery
title_full	Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery
title_fullStr	Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery
title_full_unstemmed	Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery
title_sort	natural products for pancreatic cancer treatment: from traditional medicine to modern drug discovery
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f82007ab66d0434ebe69e18df53045c0
work_keys_str_mv	AT ahyeonkim naturalproductsforpancreaticcancertreatmentfromtraditionalmedicinetomoderndrugdiscovery AT jiwonha naturalproductsforpancreaticcancertreatmentfromtraditionalmedicinetomoderndrugdiscovery AT jeongeunkim naturalproductsforpancreaticcancertreatmentfromtraditionalmedicinetomoderndrugdiscovery AT yongmincho naturalproductsforpancreaticcancertreatmentfromtraditionalmedicinetomoderndrugdiscovery AT jimyungahn naturalproductsforpancreaticcancertreatmentfromtraditionalmedicinetomoderndrugdiscovery AT chunhoocheon naturalproductsforpancreaticcancertreatmentfromtraditionalmedicinetomoderndrugdiscovery AT sunghoonkim naturalproductsforpancreaticcancertreatmentfromtraditionalmedicinetomoderndrugdiscovery AT seonggyuko naturalproductsforpancreaticcancertreatmentfromtraditionalmedicinetomoderndrugdiscovery AT bongleekim naturalproductsforpancreaticcancertreatmentfromtraditionalmedicinetomoderndrugdiscovery
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Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery

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