Understanding the Importance of Capsules in Dry Powder Inhalers

Pulmonary drug delivery is currently the focus of research and development because of its potential to produce maximum therapeutic benefit to patients by directing the drug straight to the lung disease site. Among all the available delivery options, one popular, proven and convenient inhaler device...

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Main Authors:	Francesca Buttini, Eride Quarta, Chiara Allegrini, Federico Lavorini
Format:	article
Language:	EN
Published:	MDPI AG 2021
Subjects:	capsule dry powder inhaler inhalation pulmonary drug delivery Pharmacy and materia medica RS1-441
Online Access:	https://doaj.org/article/f82288167d8a4d22836e01bd4256f5c4
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spelling	oai:doaj.org-article:f82288167d8a4d22836e01bd4256f5c42021-11-25T18:42:08ZUnderstanding the Importance of Capsules in Dry Powder Inhalers10.3390/pharmaceutics131119361999-4923https://doaj.org/article/f82288167d8a4d22836e01bd4256f5c42021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1936https://doaj.org/toc/1999-4923Pulmonary drug delivery is currently the focus of research and development because of its potential to produce maximum therapeutic benefit to patients by directing the drug straight to the lung disease site. Among all the available delivery options, one popular, proven and convenient inhaler device is the capsule-based dry powder inhaler (cDPI) for the treatment of an increasingly diverse range of diseases. cDPIs use a hard capsule that contains a powder formulation which consists of a mixture of a micronized drug and a carrier usually the lactose, known for its good lung tolerance. The capsule is either inserted into the device during manufacturer or by the patient prior to use. After perforating, opening or cut the capsule in the device, patients take a deep and rapid breath to inhale the powder, using air as the vector of drug displacement. The system is simple, relatively cheap and characterized by a lower carbon footprint than that of pressurized metered dose inhalers. This article reviews cDPI technology, focusing particularly on the importance of capsule characteristics and their function as a drug reservoir in cDPIs.Francesca ButtiniEride QuartaChiara AllegriniFederico LavoriniMDPI AGarticlecapsuledry powder inhalerinhalationpulmonary drug deliveryPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1936, p 1936 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	capsule dry powder inhaler inhalation pulmonary drug delivery Pharmacy and materia medica RS1-441
spellingShingle	capsule dry powder inhaler inhalation pulmonary drug delivery Pharmacy and materia medica RS1-441 Francesca Buttini Eride Quarta Chiara Allegrini Federico Lavorini Understanding the Importance of Capsules in Dry Powder Inhalers
description	Pulmonary drug delivery is currently the focus of research and development because of its potential to produce maximum therapeutic benefit to patients by directing the drug straight to the lung disease site. Among all the available delivery options, one popular, proven and convenient inhaler device is the capsule-based dry powder inhaler (cDPI) for the treatment of an increasingly diverse range of diseases. cDPIs use a hard capsule that contains a powder formulation which consists of a mixture of a micronized drug and a carrier usually the lactose, known for its good lung tolerance. The capsule is either inserted into the device during manufacturer or by the patient prior to use. After perforating, opening or cut the capsule in the device, patients take a deep and rapid breath to inhale the powder, using air as the vector of drug displacement. The system is simple, relatively cheap and characterized by a lower carbon footprint than that of pressurized metered dose inhalers. This article reviews cDPI technology, focusing particularly on the importance of capsule characteristics and their function as a drug reservoir in cDPIs.
format	article
author	Francesca Buttini Eride Quarta Chiara Allegrini Federico Lavorini
author_facet	Francesca Buttini Eride Quarta Chiara Allegrini Federico Lavorini
author_sort	Francesca Buttini
title	Understanding the Importance of Capsules in Dry Powder Inhalers
title_short	Understanding the Importance of Capsules in Dry Powder Inhalers
title_full	Understanding the Importance of Capsules in Dry Powder Inhalers
title_fullStr	Understanding the Importance of Capsules in Dry Powder Inhalers
title_full_unstemmed	Understanding the Importance of Capsules in Dry Powder Inhalers
title_sort	understanding the importance of capsules in dry powder inhalers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f82288167d8a4d22836e01bd4256f5c4
work_keys_str_mv	AT francescabuttini understandingtheimportanceofcapsulesindrypowderinhalers AT eridequarta understandingtheimportanceofcapsulesindrypowderinhalers AT chiaraallegrini understandingtheimportanceofcapsulesindrypowderinhalers AT federicolavorini understandingtheimportanceofcapsulesindrypowderinhalers
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Understanding the Importance of Capsules in Dry Powder Inhalers

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