Recent HbA1c values and mortality risk in type 2 diabetes. population-based case-control study.

This study aimed to evaluate mortality within 365 days of HbA1c values of <6.5% or >9.0% in participants with clinical type 2 diabetes mellitus. A matched nested case-control study was implemented, within a cohort of participants with type 2 diabetes from 2000 to 2008. Conditional logistic reg...

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Autores principales:	Jennifer Nicholas, Judith Charlton, Alex Dregan, Martin C Gulliford
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f825f59b1be345d6b9301bfd95568df1
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spelling	oai:doaj.org-article:f825f59b1be345d6b9301bfd95568df12021-11-18T07:38:25ZRecent HbA1c values and mortality risk in type 2 diabetes. population-based case-control study.1932-620310.1371/journal.pone.0068008https://doaj.org/article/f825f59b1be345d6b9301bfd95568df12013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23861845/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203This study aimed to evaluate mortality within 365 days of HbA1c values of <6.5% or >9.0% in participants with clinical type 2 diabetes mellitus. A matched nested case-control study was implemented, within a cohort of participants with type 2 diabetes from 2000 to 2008. Conditional logistic regression was used to model the odds ratio for mortality adjusting for comorbidity and drug utilisation. There were 97,450 participants with type 2 diabetes; 16,585 cases that died during follow up were matched to 16,585 controls. The most recent HbA1c value was <6.5% (48 mmol/mol) for 22.2% of cases and 24.2% of controls, the HbA1c was >9.0% for 9.0% of cases and 7.7% of controls. In a complete case analysis, the adjusted odds ratio (AOR) for mortality associated with most recent HbA1c <6.5% was 1.31 (95% confidence interval (CI): 1.21,1.42). After multiple imputation of missing HbA1c values the AOR was 1.20 (CI: 1.12,1.28). The complete case analysis gave an AOR for HbA1c >9.0% of 1.51 (CI: 1.33, 1.70), in the multiple imputation analysis this was 1.29 (1.17,1.41). The risk associated with HbA1c <6.5% was age dependent. In the multiple imputation analysis the AOR was 1.53 (CI: 0.84 to 2.79) at age<55 years but 1.04 (CI: 0.92, 1.17) at age 85 years and over. In non-randomised data, values of HbA1c that are either <6.5% or >9.0% may be associated with increased mortality within one year in clinical type 2 diabetes. Relative risks may be higher at younger ages.Jennifer NicholasJudith CharltonAlex DreganMartin C GullifordPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68008 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jennifer Nicholas Judith Charlton Alex Dregan Martin C Gulliford Recent HbA1c values and mortality risk in type 2 diabetes. population-based case-control study.
description	This study aimed to evaluate mortality within 365 days of HbA1c values of <6.5% or >9.0% in participants with clinical type 2 diabetes mellitus. A matched nested case-control study was implemented, within a cohort of participants with type 2 diabetes from 2000 to 2008. Conditional logistic regression was used to model the odds ratio for mortality adjusting for comorbidity and drug utilisation. There were 97,450 participants with type 2 diabetes; 16,585 cases that died during follow up were matched to 16,585 controls. The most recent HbA1c value was <6.5% (48 mmol/mol) for 22.2% of cases and 24.2% of controls, the HbA1c was >9.0% for 9.0% of cases and 7.7% of controls. In a complete case analysis, the adjusted odds ratio (AOR) for mortality associated with most recent HbA1c <6.5% was 1.31 (95% confidence interval (CI): 1.21,1.42). After multiple imputation of missing HbA1c values the AOR was 1.20 (CI: 1.12,1.28). The complete case analysis gave an AOR for HbA1c >9.0% of 1.51 (CI: 1.33, 1.70), in the multiple imputation analysis this was 1.29 (1.17,1.41). The risk associated with HbA1c <6.5% was age dependent. In the multiple imputation analysis the AOR was 1.53 (CI: 0.84 to 2.79) at age<55 years but 1.04 (CI: 0.92, 1.17) at age 85 years and over. In non-randomised data, values of HbA1c that are either <6.5% or >9.0% may be associated with increased mortality within one year in clinical type 2 diabetes. Relative risks may be higher at younger ages.
format	article
author	Jennifer Nicholas Judith Charlton Alex Dregan Martin C Gulliford
author_facet	Jennifer Nicholas Judith Charlton Alex Dregan Martin C Gulliford
author_sort	Jennifer Nicholas
title	Recent HbA1c values and mortality risk in type 2 diabetes. population-based case-control study.
title_short	Recent HbA1c values and mortality risk in type 2 diabetes. population-based case-control study.
title_full	Recent HbA1c values and mortality risk in type 2 diabetes. population-based case-control study.
title_fullStr	Recent HbA1c values and mortality risk in type 2 diabetes. population-based case-control study.
title_full_unstemmed	Recent HbA1c values and mortality risk in type 2 diabetes. population-based case-control study.
title_sort	recent hba1c values and mortality risk in type 2 diabetes. population-based case-control study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f825f59b1be345d6b9301bfd95568df1
work_keys_str_mv	AT jennifernicholas recenthba1cvaluesandmortalityriskintype2diabetespopulationbasedcasecontrolstudy AT judithcharlton recenthba1cvaluesandmortalityriskintype2diabetespopulationbasedcasecontrolstudy AT alexdregan recenthba1cvaluesandmortalityriskintype2diabetespopulationbasedcasecontrolstudy AT martincgulliford recenthba1cvaluesandmortalityriskintype2diabetespopulationbasedcasecontrolstudy
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Recent HbA1c values and mortality risk in type 2 diabetes. population-based case-control study.

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