Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain

Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain

The WD40 domain of ATG16L1 is thought to be involved in non-canonical autophagy. Here the authors screen peptide libraries and identify interactions between this domain and the IL-2Rγ and IL-10RB receptors, indicating endosomal regulation of cytokine signalling by non-canonical autophagy.

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Detalles Bibliográficos
Autores principales: Inmaculada Serramito-Gómez, Emilio Boada-Romero, Raquel Villamuera, Álvaro Fernández-Cabrera, José Luis Cedillo, Ángela Martín-Regalado, Simon Carding, Uli Mayer, Penny P. Powell, Thomas Wileman, Irene García-Higuera, Felipe X. Pimentel-Muiños
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f827951d5bc9452e960cbed014b2d5d6
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Descripción
Sumario:The WD40 domain of ATG16L1 is thought to be involved in non-canonical autophagy. Here the authors screen peptide libraries and identify interactions between this domain and the IL-2Rγ and IL-10RB receptors, indicating endosomal regulation of cytokine signalling by non-canonical autophagy.

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