Neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization in adulthood

Abstract Adverse perinatal conditions can lead to developmental programming of cardiovascular diseases. Prematurely born infants are often exposed to high oxygen levels, which in animal models has been associated with endothelial dysfunction, hypertension, and cardiac remodeling during adulthood. He...

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Autores principales:	Raphael Mathieu, Sylvie Dussault, Michel Desjarlais, François Rivard, Wahiba Dhahri, Anik Cloutier, Anne-Monique Nuyt, Alain Rivard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f82ba77dde434355ab36b34a1d84dc4e
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spelling	oai:doaj.org-article:f82ba77dde434355ab36b34a1d84dc4e2021-12-02T11:52:44ZNeonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization in adulthood10.1038/s41598-017-14396-82045-2322https://doaj.org/article/f82ba77dde434355ab36b34a1d84dc4e2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-14396-8https://doaj.org/toc/2045-2322Abstract Adverse perinatal conditions can lead to developmental programming of cardiovascular diseases. Prematurely born infants are often exposed to high oxygen levels, which in animal models has been associated with endothelial dysfunction, hypertension, and cardiac remodeling during adulthood. Here we found that adult mice that have been transiently exposed to O2 after birth show defective neovasculariation after hindlimb ischemia, as demonstrated by impaired blood flow recovery, reduced vascular density in ischemic muscles and increased tissue damages. Ischemic muscles isolated from mice exposed to O2 after birth exhibit increased oxidative stress levels and reduced expression of superoxide dismutase 1 (SOD1) and vascular endothelial growth factor (VEGF). Pro-angiogenic cells (PACs) have been shown to have an important role for postnatal neovascularisation. We found that neonatal exposure to O2 is associated with reduced number of PACs in adults. Moreover, the angiogenic activities of both PACs and mature mouse aortic endothelial cells (MAECs) are significantly impaired in mice exposed to hyperoxia after birth. Our results indicate that neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization during adulthood. The mechanism involves deleterious effects on oxidative stress levels and angiogenic signals in ischemic muscles, together with dysfunctional activities of PACs and mature endothelial cells.Raphael MathieuSylvie DussaultMichel DesjarlaisFrançois RivardWahiba DhahriAnik CloutierAnne-Monique NuytAlain RivardNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Raphael Mathieu Sylvie Dussault Michel Desjarlais François Rivard Wahiba Dhahri Anik Cloutier Anne-Monique Nuyt Alain Rivard Neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization in adulthood
description	Abstract Adverse perinatal conditions can lead to developmental programming of cardiovascular diseases. Prematurely born infants are often exposed to high oxygen levels, which in animal models has been associated with endothelial dysfunction, hypertension, and cardiac remodeling during adulthood. Here we found that adult mice that have been transiently exposed to O2 after birth show defective neovasculariation after hindlimb ischemia, as demonstrated by impaired blood flow recovery, reduced vascular density in ischemic muscles and increased tissue damages. Ischemic muscles isolated from mice exposed to O2 after birth exhibit increased oxidative stress levels and reduced expression of superoxide dismutase 1 (SOD1) and vascular endothelial growth factor (VEGF). Pro-angiogenic cells (PACs) have been shown to have an important role for postnatal neovascularisation. We found that neonatal exposure to O2 is associated with reduced number of PACs in adults. Moreover, the angiogenic activities of both PACs and mature mouse aortic endothelial cells (MAECs) are significantly impaired in mice exposed to hyperoxia after birth. Our results indicate that neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization during adulthood. The mechanism involves deleterious effects on oxidative stress levels and angiogenic signals in ischemic muscles, together with dysfunctional activities of PACs and mature endothelial cells.
format	article
author	Raphael Mathieu Sylvie Dussault Michel Desjarlais François Rivard Wahiba Dhahri Anik Cloutier Anne-Monique Nuyt Alain Rivard
author_facet	Raphael Mathieu Sylvie Dussault Michel Desjarlais François Rivard Wahiba Dhahri Anik Cloutier Anne-Monique Nuyt Alain Rivard
author_sort	Raphael Mathieu
title	Neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization in adulthood
title_short	Neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization in adulthood
title_full	Neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization in adulthood
title_fullStr	Neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization in adulthood
title_full_unstemmed	Neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization in adulthood
title_sort	neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization in adulthood
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f82ba77dde434355ab36b34a1d84dc4e
work_keys_str_mv	AT raphaelmathieu neonatalexposuretohighoxygenlevelsleadstoimpairedischemiainducedneovascularizationinadulthood AT sylviedussault neonatalexposuretohighoxygenlevelsleadstoimpairedischemiainducedneovascularizationinadulthood AT micheldesjarlais neonatalexposuretohighoxygenlevelsleadstoimpairedischemiainducedneovascularizationinadulthood AT francoisrivard neonatalexposuretohighoxygenlevelsleadstoimpairedischemiainducedneovascularizationinadulthood AT wahibadhahri neonatalexposuretohighoxygenlevelsleadstoimpairedischemiainducedneovascularizationinadulthood AT anikcloutier neonatalexposuretohighoxygenlevelsleadstoimpairedischemiainducedneovascularizationinadulthood AT annemoniquenuyt neonatalexposuretohighoxygenlevelsleadstoimpairedischemiainducedneovascularizationinadulthood AT alainrivard neonatalexposuretohighoxygenlevelsleadstoimpairedischemiainducedneovascularizationinadulthood
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Neonatal exposure to high oxygen levels leads to impaired ischemia-induced neovascularization in adulthood

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