Regulatory network of miRNA, lncRNA, transcription factor and target immune response genes in bovine mastitis

Abstract Pre- and post-transcriptional modifications of gene expression are emerging as foci of disease studies, with some studies revealing the importance of non-coding transcripts, like long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). We hypothesize that transcription factors (TFs), lncRNAs...

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Autores principales:	Ashley R. Tucker, Nicole A. Salazar, Adeola O. Ayoola, Erdoğan Memili, Bolaji N. Thomas, Olanrewaju B. Morenikeji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f82c8b63dbce47d7a7b3290a079026c8
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spelling	oai:doaj.org-article:f82c8b63dbce47d7a7b3290a079026c82021-11-14T12:24:36ZRegulatory network of miRNA, lncRNA, transcription factor and target immune response genes in bovine mastitis10.1038/s41598-021-01280-92045-2322https://doaj.org/article/f82c8b63dbce47d7a7b3290a079026c82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01280-9https://doaj.org/toc/2045-2322Abstract Pre- and post-transcriptional modifications of gene expression are emerging as foci of disease studies, with some studies revealing the importance of non-coding transcripts, like long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). We hypothesize that transcription factors (TFs), lncRNAs and miRNAs modulate immune response in bovine mastitis and could potentially serve as disease biomarkers and/or drug targets. With computational analyses, we identified candidate genes potentially regulated by miRNAs and lncRNAs base pair complementation and thermodynamic stability of binding regions. Remarkably, we found six miRNAs, two being bta-miR-223 and bta-miR-24-3p, to bind to several targets. LncRNAs NONBTAT027932.1 and XR_003029725.1, were identified to target several genes. Functional and pathway analyses revealed lipopolysaccharide-mediated signaling pathway, regulation of chemokine (C-X-C motif) ligand 2 production and regulation of IL-23 production among others. The overarching interactome deserves further in vitro/in vivo explication for specific molecular regulatory mechanisms during bovine mastitis immune response and could lay the foundation for development of disease markers and therapeutic intervention.Ashley R. TuckerNicole A. SalazarAdeola O. AyoolaErdoğan MemiliBolaji N. ThomasOlanrewaju B. MorenikejiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ashley R. Tucker Nicole A. Salazar Adeola O. Ayoola Erdoğan Memili Bolaji N. Thomas Olanrewaju B. Morenikeji Regulatory network of miRNA, lncRNA, transcription factor and target immune response genes in bovine mastitis
description	Abstract Pre- and post-transcriptional modifications of gene expression are emerging as foci of disease studies, with some studies revealing the importance of non-coding transcripts, like long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). We hypothesize that transcription factors (TFs), lncRNAs and miRNAs modulate immune response in bovine mastitis and could potentially serve as disease biomarkers and/or drug targets. With computational analyses, we identified candidate genes potentially regulated by miRNAs and lncRNAs base pair complementation and thermodynamic stability of binding regions. Remarkably, we found six miRNAs, two being bta-miR-223 and bta-miR-24-3p, to bind to several targets. LncRNAs NONBTAT027932.1 and XR_003029725.1, were identified to target several genes. Functional and pathway analyses revealed lipopolysaccharide-mediated signaling pathway, regulation of chemokine (C-X-C motif) ligand 2 production and regulation of IL-23 production among others. The overarching interactome deserves further in vitro/in vivo explication for specific molecular regulatory mechanisms during bovine mastitis immune response and could lay the foundation for development of disease markers and therapeutic intervention.
format	article
author	Ashley R. Tucker Nicole A. Salazar Adeola O. Ayoola Erdoğan Memili Bolaji N. Thomas Olanrewaju B. Morenikeji
author_facet	Ashley R. Tucker Nicole A. Salazar Adeola O. Ayoola Erdoğan Memili Bolaji N. Thomas Olanrewaju B. Morenikeji
author_sort	Ashley R. Tucker
title	Regulatory network of miRNA, lncRNA, transcription factor and target immune response genes in bovine mastitis
title_short	Regulatory network of miRNA, lncRNA, transcription factor and target immune response genes in bovine mastitis
title_full	Regulatory network of miRNA, lncRNA, transcription factor and target immune response genes in bovine mastitis
title_fullStr	Regulatory network of miRNA, lncRNA, transcription factor and target immune response genes in bovine mastitis
title_full_unstemmed	Regulatory network of miRNA, lncRNA, transcription factor and target immune response genes in bovine mastitis
title_sort	regulatory network of mirna, lncrna, transcription factor and target immune response genes in bovine mastitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f82c8b63dbce47d7a7b3290a079026c8
work_keys_str_mv	AT ashleyrtucker regulatorynetworkofmirnalncrnatranscriptionfactorandtargetimmuneresponsegenesinbovinemastitis AT nicoleasalazar regulatorynetworkofmirnalncrnatranscriptionfactorandtargetimmuneresponsegenesinbovinemastitis AT adeolaoayoola regulatorynetworkofmirnalncrnatranscriptionfactorandtargetimmuneresponsegenesinbovinemastitis AT erdoganmemili regulatorynetworkofmirnalncrnatranscriptionfactorandtargetimmuneresponsegenesinbovinemastitis AT bolajinthomas regulatorynetworkofmirnalncrnatranscriptionfactorandtargetimmuneresponsegenesinbovinemastitis AT olanrewajubmorenikeji regulatorynetworkofmirnalncrnatranscriptionfactorandtargetimmuneresponsegenesinbovinemastitis
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Regulatory network of miRNA, lncRNA, transcription factor and target immune response genes in bovine mastitis

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