Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci

Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci

Here the authors report a major histocompatibility complex (MHC) association analysis for nasopharyngeal carcinoma in Chinese individuals from Hong Kong, finding 8 independent associated loci associated with lower risk for developing nasopharyngeal carcinoma. Two non-human leukocyte antigen (HLA) ge...

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Autores principales: Lvwen Ning, Josephine Mun-Yee Ko, Valen Zhuoyou Yu, Hoi Yan Ng, Candy King-Chi Chan, Lihua Tao, Shiu-Yeung Lam, Merrin Man-Long Leong, Roger Kai-Cheong Ngan, Dora Lai-Wan Kwong, Anne Wing-Mui Lee, Wai-Tong Ng, Ashley Cheng, Stewart Tung, Victor Ho-Fun Lee, Ka-On Lam, Chung-Kong Kwan, Wing-Sum Li, Stephen Yau, Jin-Xin Bei, Maria Li Lung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/f82cb968f4d947bb91dd4a6ed21c1e75
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Sumario:Here the authors report a major histocompatibility complex (MHC) association analysis for nasopharyngeal carcinoma in Chinese individuals from Hong Kong, finding 8 independent associated loci associated with lower risk for developing nasopharyngeal carcinoma. Two non-human leukocyte antigen (HLA) genes are E3 ubiquitin ligases, TRIM31 and TRIM39, having a role in the innate immune response and implicating the importance of host Epstein-Barr virus interactions in this cancer.

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