Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci

Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci

Here the authors report a major histocompatibility complex (MHC) association analysis for nasopharyngeal carcinoma in Chinese individuals from Hong Kong, finding 8 independent associated loci associated with lower risk for developing nasopharyngeal carcinoma. Two non-human leukocyte antigen (HLA) ge...

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Autores principales: Lvwen Ning, Josephine Mun-Yee Ko, Valen Zhuoyou Yu, Hoi Yan Ng, Candy King-Chi Chan, Lihua Tao, Shiu-Yeung Lam, Merrin Man-Long Leong, Roger Kai-Cheong Ngan, Dora Lai-Wan Kwong, Anne Wing-Mui Lee, Wai-Tong Ng, Ashley Cheng, Stewart Tung, Victor Ho-Fun Lee, Ka-On Lam, Chung-Kong Kwan, Wing-Sum Li, Stephen Yau, Jin-Xin Bei, Maria Li Lung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/f82cb968f4d947bb91dd4a6ed21c1e75
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spelling oai:doaj.org-article:f82cb968f4d947bb91dd4a6ed21c1e752021-12-02T16:18:00ZNasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci10.1038/s42003-020-01487-y2399-3642https://doaj.org/article/f82cb968f4d947bb91dd4a6ed21c1e752020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01487-yhttps://doaj.org/toc/2399-3642Here the authors report a major histocompatibility complex (MHC) association analysis for nasopharyngeal carcinoma in Chinese individuals from Hong Kong, finding 8 independent associated loci associated with lower risk for developing nasopharyngeal carcinoma. Two non-human leukocyte antigen (HLA) genes are E3 ubiquitin ligases, TRIM31 and TRIM39, having a role in the innate immune response and implicating the importance of host Epstein-Barr virus interactions in this cancer.Lvwen NingJosephine Mun-Yee KoValen Zhuoyou YuHoi Yan NgCandy King-Chi ChanLihua TaoShiu-Yeung LamMerrin Man-Long LeongRoger Kai-Cheong NganDora Lai-Wan KwongAnne Wing-Mui LeeWai-Tong NgAshley ChengStewart TungVictor Ho-Fun LeeKa-On LamChung-Kong KwanWing-Sum LiStephen YauJin-Xin BeiMaria Li LungNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Lvwen Ning
Josephine Mun-Yee Ko
Valen Zhuoyou Yu
Hoi Yan Ng
Candy King-Chi Chan
Lihua Tao
Shiu-Yeung Lam
Merrin Man-Long Leong
Roger Kai-Cheong Ngan
Dora Lai-Wan Kwong
Anne Wing-Mui Lee
Wai-Tong Ng
Ashley Cheng
Stewart Tung
Victor Ho-Fun Lee
Ka-On Lam
Chung-Kong Kwan
Wing-Sum Li
Stephen Yau
Jin-Xin Bei
Maria Li Lung
Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci
description Here the authors report a major histocompatibility complex (MHC) association analysis for nasopharyngeal carcinoma in Chinese individuals from Hong Kong, finding 8 independent associated loci associated with lower risk for developing nasopharyngeal carcinoma. Two non-human leukocyte antigen (HLA) genes are E3 ubiquitin ligases, TRIM31 and TRIM39, having a role in the innate immune response and implicating the importance of host Epstein-Barr virus interactions in this cancer.
format article
author Lvwen Ning
Josephine Mun-Yee Ko
Valen Zhuoyou Yu
Hoi Yan Ng
Candy King-Chi Chan
Lihua Tao
Shiu-Yeung Lam
Merrin Man-Long Leong
Roger Kai-Cheong Ngan
Dora Lai-Wan Kwong
Anne Wing-Mui Lee
Wai-Tong Ng
Ashley Cheng
Stewart Tung
Victor Ho-Fun Lee
Ka-On Lam
Chung-Kong Kwan
Wing-Sum Li
Stephen Yau
Jin-Xin Bei
Maria Li Lung
author_facet Lvwen Ning
Josephine Mun-Yee Ko
Valen Zhuoyou Yu
Hoi Yan Ng
Candy King-Chi Chan
Lihua Tao
Shiu-Yeung Lam
Merrin Man-Long Leong
Roger Kai-Cheong Ngan
Dora Lai-Wan Kwong
Anne Wing-Mui Lee
Wai-Tong Ng
Ashley Cheng
Stewart Tung
Victor Ho-Fun Lee
Ka-On Lam
Chung-Kong Kwan
Wing-Sum Li
Stephen Yau
Jin-Xin Bei
Maria Li Lung
author_sort Lvwen Ning
title Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci
title_short Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci
title_full Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci
title_fullStr Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci
title_full_unstemmed Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci
title_sort nasopharyngeal carcinoma mhc region deep sequencing identifies hla and novel non-hla trim31 and trim39 loci
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/f82cb968f4d947bb91dd4a6ed21c1e75
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