Efficacious and safe control of glycemia using Apidra insulin

Diabetes mellitus (DM) is a stably growing pathology leading to micro- and macrovascular complications. Despite high potential of medicamentaltherapy for DM its efficacy needs to be further improved. Uncompensated postprandial hyperglycemia is known to be responsible for many diabeticcomplications....

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Autores principales:	Elena Valer'evna Biryukova, Maria Alexandrovna Garbuzova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2010
Materias:	diabetes mellitus hyperglycemia complications treatment apidra glulysine Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/f82f368724944cdb8da4a2a61c74cc87
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spelling	oai:doaj.org-article:f82f368724944cdb8da4a2a61c74cc872021-11-14T09:00:15ZEfficacious and safe control of glycemia using Apidra insulin2072-03512072-037810.14341/2072-0351-5492https://doaj.org/article/f82f368724944cdb8da4a2a61c74cc872010-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5492https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Diabetes mellitus (DM) is a stably growing pathology leading to micro- and macrovascular complications. Despite high potential of medicamentaltherapy for DM its efficacy needs to be further improved. Uncompensated postprandial hyperglycemia is known to be responsible for many diabeticcomplications. Moreover, it by itself aggravates disturbances of insulin secretion through the toxic effect of glucose. Insulin therapy remains a principaltool for the treatment of DM. Its efficiency was greatly improved with the advent of fast-acting insulin analogs obtained by reducing stability of hexamers.Insulin glulysine (Apidra) is the fastest-acting analog licensed for the treatment of DM1 and DM2 in adult patients in 2004 (FDA, EMEA) andin children above 6 years in 2008 (EMEA). A characteristic feature of this analog is the absence of Zn2+ in its molecule that substitutes polysorbate-20 acting as a surfactant and providing additional protection of monomers from denaturation.Elena Valer'evna BiryukovaMaria Alexandrovna GarbuzovaEndocrinology Research Centrearticlediabetes mellitushyperglycemiacomplicationstreatmentapidraglulysineNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 13, Iss 3, Pp 72-77 (2010)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus hyperglycemia complications treatment apidra glulysine Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus hyperglycemia complications treatment apidra glulysine Nutritional diseases. Deficiency diseases RC620-627 Elena Valer'evna Biryukova Maria Alexandrovna Garbuzova Efficacious and safe control of glycemia using Apidra insulin
description	Diabetes mellitus (DM) is a stably growing pathology leading to micro- and macrovascular complications. Despite high potential of medicamentaltherapy for DM its efficacy needs to be further improved. Uncompensated postprandial hyperglycemia is known to be responsible for many diabeticcomplications. Moreover, it by itself aggravates disturbances of insulin secretion through the toxic effect of glucose. Insulin therapy remains a principaltool for the treatment of DM. Its efficiency was greatly improved with the advent of fast-acting insulin analogs obtained by reducing stability of hexamers.Insulin glulysine (Apidra) is the fastest-acting analog licensed for the treatment of DM1 and DM2 in adult patients in 2004 (FDA, EMEA) andin children above 6 years in 2008 (EMEA). A characteristic feature of this analog is the absence of Zn2+ in its molecule that substitutes polysorbate-20 acting as a surfactant and providing additional protection of monomers from denaturation.
format	article
author	Elena Valer'evna Biryukova Maria Alexandrovna Garbuzova
author_facet	Elena Valer'evna Biryukova Maria Alexandrovna Garbuzova
author_sort	Elena Valer'evna Biryukova
title	Efficacious and safe control of glycemia using Apidra insulin
title_short	Efficacious and safe control of glycemia using Apidra insulin
title_full	Efficacious and safe control of glycemia using Apidra insulin
title_fullStr	Efficacious and safe control of glycemia using Apidra insulin
title_full_unstemmed	Efficacious and safe control of glycemia using Apidra insulin
title_sort	efficacious and safe control of glycemia using apidra insulin
publisher	Endocrinology Research Centre
publishDate	2010
url	https://doaj.org/article/f82f368724944cdb8da4a2a61c74cc87
work_keys_str_mv	AT elenavalerevnabiryukova efficaciousandsafecontrolofglycemiausingapidrainsulin AT mariaalexandrovnagarbuzova efficaciousandsafecontrolofglycemiausingapidrainsulin
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Efficacious and safe control of glycemia using Apidra insulin

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