Structure of transcribing RNA polymerase II-nucleosome complex

Eukaryotic transcription requires passage of RNA polymerase II (Pol II) through chromatin, which is impaired by nucleosomes. Here the authors report the cryo-EM structure of transcribing Pol II engaged with a downstream nucleosome core particle at an overall resolution of 4.4 Å, providing insights i...

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Autores principales:	Lucas Farnung, Seychelle M. Vos, Patrick Cramer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f832447ece5a402da1f4a0d40d65ef34
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spelling	oai:doaj.org-article:f832447ece5a402da1f4a0d40d65ef342021-12-02T14:39:04ZStructure of transcribing RNA polymerase II-nucleosome complex10.1038/s41467-018-07870-y2041-1723https://doaj.org/article/f832447ece5a402da1f4a0d40d65ef342018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07870-yhttps://doaj.org/toc/2041-1723Eukaryotic transcription requires passage of RNA polymerase II (Pol II) through chromatin, which is impaired by nucleosomes. Here the authors report the cryo-EM structure of transcribing Pol II engaged with a downstream nucleosome core particle at an overall resolution of 4.4 Å, providing insights into the mechanism of chromatin transcription.Lucas FarnungSeychelle M. VosPatrick CramerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucas Farnung Seychelle M. Vos Patrick Cramer Structure of transcribing RNA polymerase II-nucleosome complex
description	Eukaryotic transcription requires passage of RNA polymerase II (Pol II) through chromatin, which is impaired by nucleosomes. Here the authors report the cryo-EM structure of transcribing Pol II engaged with a downstream nucleosome core particle at an overall resolution of 4.4 Å, providing insights into the mechanism of chromatin transcription.
format	article
author	Lucas Farnung Seychelle M. Vos Patrick Cramer
author_facet	Lucas Farnung Seychelle M. Vos Patrick Cramer
author_sort	Lucas Farnung
title	Structure of transcribing RNA polymerase II-nucleosome complex
title_short	Structure of transcribing RNA polymerase II-nucleosome complex
title_full	Structure of transcribing RNA polymerase II-nucleosome complex
title_fullStr	Structure of transcribing RNA polymerase II-nucleosome complex
title_full_unstemmed	Structure of transcribing RNA polymerase II-nucleosome complex
title_sort	structure of transcribing rna polymerase ii-nucleosome complex
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f832447ece5a402da1f4a0d40d65ef34
work_keys_str_mv	AT lucasfarnung structureoftranscribingrnapolymeraseiinucleosomecomplex AT seychellemvos structureoftranscribingrnapolymeraseiinucleosomecomplex AT patrickcramer structureoftranscribingrnapolymeraseiinucleosomecomplex
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Structure of transcribing RNA polymerase II-nucleosome complex

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