Convenient and effective ICGylation of magnetic nanoparticles for biomedical applications

Abstract Nanoprobes used for biomedical applications usually require surface modifications with amphiphilic surfactants or inorganic coating materials to enhance their biocompatibility. We proposed a facile synthetic approach for the phase transfer of hydrophobic magnetic nanoparticles by the direct...

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Autores principales:	Hye Sun Park, Jongwoo Kim, Mi Young Cho, Hyunseung Lee, Sang Hwan Nam, Yung Doug Suh, Kwan Soo Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f83307ab3bfd416c93410c44d142b886
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spelling	oai:doaj.org-article:f83307ab3bfd416c93410c44d142b8862021-12-02T12:32:16ZConvenient and effective ICGylation of magnetic nanoparticles for biomedical applications10.1038/s41598-017-09627-x2045-2322https://doaj.org/article/f83307ab3bfd416c93410c44d142b8862017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09627-xhttps://doaj.org/toc/2045-2322Abstract Nanoprobes used for biomedical applications usually require surface modifications with amphiphilic surfactants or inorganic coating materials to enhance their biocompatibility. We proposed a facile synthetic approach for the phase transfer of hydrophobic magnetic nanoparticles by the direct adherence of fluorescent probes, without any chemical modifications, for use as a magnetic resonance (MR)/near-infrared (NIR) fluorescence bimodal imaging contrast agent. Indocyanine green (ICG) was used not only as an optical component for NIR imaging, but also as a surfactant for phase transfer with no superfluous moiety: we therefore called the process “ICGylation”. Cell labeling and tracking in vivo with ICGylated magnetic nanoparticles were successfully performed by MR/NIR dual-mode imaging for three days, which showed remarkable biostability without any additional surface functionalization. We expect that this novel MR/NIR contrast agent demonstrating sensitive detection and simultaneous imaging capability can be used in diverse fields, such as the imaging and tracking of immune cells to confirm immunotherapeutic efficacy. The approach used could also be applied to other kinds of nanoparticles, and it would promote the development of advanced functional multimodal nanobioprobes.Hye Sun ParkJongwoo KimMi Young ChoHyunseung LeeSang Hwan NamYung Doug SuhKwan Soo HongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hye Sun Park Jongwoo Kim Mi Young Cho Hyunseung Lee Sang Hwan Nam Yung Doug Suh Kwan Soo Hong Convenient and effective ICGylation of magnetic nanoparticles for biomedical applications
description	Abstract Nanoprobes used for biomedical applications usually require surface modifications with amphiphilic surfactants or inorganic coating materials to enhance their biocompatibility. We proposed a facile synthetic approach for the phase transfer of hydrophobic magnetic nanoparticles by the direct adherence of fluorescent probes, without any chemical modifications, for use as a magnetic resonance (MR)/near-infrared (NIR) fluorescence bimodal imaging contrast agent. Indocyanine green (ICG) was used not only as an optical component for NIR imaging, but also as a surfactant for phase transfer with no superfluous moiety: we therefore called the process “ICGylation”. Cell labeling and tracking in vivo with ICGylated magnetic nanoparticles were successfully performed by MR/NIR dual-mode imaging for three days, which showed remarkable biostability without any additional surface functionalization. We expect that this novel MR/NIR contrast agent demonstrating sensitive detection and simultaneous imaging capability can be used in diverse fields, such as the imaging and tracking of immune cells to confirm immunotherapeutic efficacy. The approach used could also be applied to other kinds of nanoparticles, and it would promote the development of advanced functional multimodal nanobioprobes.
format	article
author	Hye Sun Park Jongwoo Kim Mi Young Cho Hyunseung Lee Sang Hwan Nam Yung Doug Suh Kwan Soo Hong
author_facet	Hye Sun Park Jongwoo Kim Mi Young Cho Hyunseung Lee Sang Hwan Nam Yung Doug Suh Kwan Soo Hong
author_sort	Hye Sun Park
title	Convenient and effective ICGylation of magnetic nanoparticles for biomedical applications
title_short	Convenient and effective ICGylation of magnetic nanoparticles for biomedical applications
title_full	Convenient and effective ICGylation of magnetic nanoparticles for biomedical applications
title_fullStr	Convenient and effective ICGylation of magnetic nanoparticles for biomedical applications
title_full_unstemmed	Convenient and effective ICGylation of magnetic nanoparticles for biomedical applications
title_sort	convenient and effective icgylation of magnetic nanoparticles for biomedical applications
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f83307ab3bfd416c93410c44d142b886
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_version_	1718394133122383872

Convenient and effective ICGylation of magnetic nanoparticles for biomedical applications

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