The function of non-coding RNAs in idiopathic pulmonary fibrosis
Non-coding ribonucleic acids (ncRNAs) are a diverse group of RNA molecules that are mostly not translated into proteins after transcription, including long non-coding RNAs (lncRNAs) with longer than 200 nucleotides non-coding transcripts and microRNAs (miRNAs) which are only 18–22 nucleotides. As fa...
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De Gruyter
2021
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oai:doaj.org-article:f833b082066b48048ade7950da1dd0c12021-12-05T14:10:54ZThe function of non-coding RNAs in idiopathic pulmonary fibrosis2391-546310.1515/med-2021-0231https://doaj.org/article/f833b082066b48048ade7950da1dd0c12021-03-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0231https://doaj.org/toc/2391-5463Non-coding ribonucleic acids (ncRNAs) are a diverse group of RNA molecules that are mostly not translated into proteins after transcription, including long non-coding RNAs (lncRNAs) with longer than 200 nucleotides non-coding transcripts and microRNAs (miRNAs) which are only 18–22 nucleotides. As families of evolutionarily conserved ncRNAs, lncRNAs activate and repress genes via a variety of mechanisms at both transcriptional and translational levels, whereas miRNAs regulate protein-coding gene expression mainly through mRNA silencing. ncRNAs are widely involved in biological functions, such as proliferation, differentiation, migration, angiogenesis, and apoptosis. Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a poor prognosis. The etiology of IPF is still unclear. Increasing evidence shows the close correlations between the development of IPF and aberrant expressions of ncRNAs than thought previously. In this study, we provide an overview of ncRNAs participated in pathobiology of IPF, seeking the early diagnosis biomarker and aiming for potential therapeutic applications for IPF.Zhang HuiSong MiaoGuo JianingMa JunbingQiu MinYang ZhengDe GruyterarticlencrnasmirnaslncrnasipfpathogenesisMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 481-490 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
ncrnas mirnas lncrnas ipf pathogenesis Medicine R |
| spellingShingle |
ncrnas mirnas lncrnas ipf pathogenesis Medicine R Zhang Hui Song Miao Guo Jianing Ma Junbing Qiu Min Yang Zheng The function of non-coding RNAs in idiopathic pulmonary fibrosis |
| description |
Non-coding ribonucleic acids (ncRNAs) are a diverse group of RNA molecules that are mostly not translated into proteins after transcription, including long non-coding RNAs (lncRNAs) with longer than 200 nucleotides non-coding transcripts and microRNAs (miRNAs) which are only 18–22 nucleotides. As families of evolutionarily conserved ncRNAs, lncRNAs activate and repress genes via a variety of mechanisms at both transcriptional and translational levels, whereas miRNAs regulate protein-coding gene expression mainly through mRNA silencing. ncRNAs are widely involved in biological functions, such as proliferation, differentiation, migration, angiogenesis, and apoptosis. Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a poor prognosis. The etiology of IPF is still unclear. Increasing evidence shows the close correlations between the development of IPF and aberrant expressions of ncRNAs than thought previously. In this study, we provide an overview of ncRNAs participated in pathobiology of IPF, seeking the early diagnosis biomarker and aiming for potential therapeutic applications for IPF. |
| format |
article |
| author |
Zhang Hui Song Miao Guo Jianing Ma Junbing Qiu Min Yang Zheng |
| author_facet |
Zhang Hui Song Miao Guo Jianing Ma Junbing Qiu Min Yang Zheng |
| author_sort |
Zhang Hui |
| title |
The function of non-coding RNAs in idiopathic pulmonary fibrosis |
| title_short |
The function of non-coding RNAs in idiopathic pulmonary fibrosis |
| title_full |
The function of non-coding RNAs in idiopathic pulmonary fibrosis |
| title_fullStr |
The function of non-coding RNAs in idiopathic pulmonary fibrosis |
| title_full_unstemmed |
The function of non-coding RNAs in idiopathic pulmonary fibrosis |
| title_sort |
function of non-coding rnas in idiopathic pulmonary fibrosis |
| publisher |
De Gruyter |
| publishDate |
2021 |
| url |
https://doaj.org/article/f833b082066b48048ade7950da1dd0c1 |
| work_keys_str_mv |
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