Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery

Juqun Xi,1 Jin Qin,2 Lei Fan21Department of Pharmacology, Yangzhou University Medical Academy, Yangzhou, People&#39;s Republic of China; 2School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, People&#39;s Republic of ChinaAbstract: Mesoporous silica nanoparticl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xi J, Qin J, Fan L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f8391e05c9474590af12efaac4492df5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f8391e05c9474590af12efaac4492df5
record_format	dspace
spelling	oai:doaj.org-article:f8391e05c9474590af12efaac4492df52021-12-02T06:49:24ZChondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery1176-91141178-2013https://doaj.org/article/f8391e05c9474590af12efaac4492df52012-10-01T00:00:00Zhttp://www.dovepress.com/chondroitin-sulfate-functionalized-mesostructured-silica-nanoparticles-a11218https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Juqun Xi,1 Jin Qin,2 Lei Fan21Department of Pharmacology, Yangzhou University Medical Academy, Yangzhou, People&#39;s Republic of China; 2School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, People&#39;s Republic of ChinaAbstract: Mesoporous silica nanoparticles (MSNs) have garnered a great deal of attention as potential carriers for therapeutic payloads. Here, we report a pH-responsive drug-carrier based on chondroitin sulfate functionalized mesostructured silica nanoparticles (NMChS-MSNs) ie, the amidation between NMChS macromer and amino group functionalized MSNs. The prepared nanoparticles were characterized using dynamic light scattering, fourier transform infrared spectroscopy and transmission electron microscopy. The resultant NMChS-MSNs were uniform spherical nanoparticles with a mean diameter of approximately 74 nm. Due to the covalent graft of hydrophilic and pH responsive NMChS, the NMChS-MSNs could be well dispersed in aqueous solution, which is favorable to being utilized as drug carriers to construct a pH-responsive controlled drug delivery system. Doxorubicin hydrochloride (DOX), a well-known anticancer drug, could be effectively loaded into the channels of NMChS-MSNs through electrostatic interactions between drug and matrix. The drug release rate of DOX@NMChS-MSNs was pH dependent and increased with the decrease of pH. The in vitro cytotoxicity test indicated that NMChS-MSNs were highly biocompatible and suitable to use as drug carriers. Our results imply that chondroitin sulfate functionalized nanoparticles are promising platforms to construct the pH-responsive controlled drug delivery systems for cancer therapy.Keywords: mesoporous silica nanoparticle, pH sensitive, chondroitin sulfate, drug deliveryXi JQin JFan LDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5235-5247 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xi J Qin J Fan L Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery
description	Juqun Xi,1 Jin Qin,2 Lei Fan21Department of Pharmacology, Yangzhou University Medical Academy, Yangzhou, People&#39;s Republic of China; 2School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, People&#39;s Republic of ChinaAbstract: Mesoporous silica nanoparticles (MSNs) have garnered a great deal of attention as potential carriers for therapeutic payloads. Here, we report a pH-responsive drug-carrier based on chondroitin sulfate functionalized mesostructured silica nanoparticles (NMChS-MSNs) ie, the amidation between NMChS macromer and amino group functionalized MSNs. The prepared nanoparticles were characterized using dynamic light scattering, fourier transform infrared spectroscopy and transmission electron microscopy. The resultant NMChS-MSNs were uniform spherical nanoparticles with a mean diameter of approximately 74 nm. Due to the covalent graft of hydrophilic and pH responsive NMChS, the NMChS-MSNs could be well dispersed in aqueous solution, which is favorable to being utilized as drug carriers to construct a pH-responsive controlled drug delivery system. Doxorubicin hydrochloride (DOX), a well-known anticancer drug, could be effectively loaded into the channels of NMChS-MSNs through electrostatic interactions between drug and matrix. The drug release rate of DOX@NMChS-MSNs was pH dependent and increased with the decrease of pH. The in vitro cytotoxicity test indicated that NMChS-MSNs were highly biocompatible and suitable to use as drug carriers. Our results imply that chondroitin sulfate functionalized nanoparticles are promising platforms to construct the pH-responsive controlled drug delivery systems for cancer therapy.Keywords: mesoporous silica nanoparticle, pH sensitive, chondroitin sulfate, drug delivery
format	article
author	Xi J Qin J Fan L
author_facet	Xi J Qin J Fan L
author_sort	Xi J
title	Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery
title_short	Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery
title_full	Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery
title_fullStr	Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery
title_full_unstemmed	Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery
title_sort	chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/f8391e05c9474590af12efaac4492df5
work_keys_str_mv	AT xij chondroitinsulfatefunctionalizedmesostructuredsilicananoparticlesasbiocompatiblecarriersfordrugdelivery AT qinj chondroitinsulfatefunctionalizedmesostructuredsilicananoparticlesasbiocompatiblecarriersfordrugdelivery AT fanl chondroitinsulfatefunctionalizedmesostructuredsilicananoparticlesasbiocompatiblecarriersfordrugdelivery
_version_	1718399730917048320

Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery

Ejemplares similares