Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.

Aging-induced deterioration of arterial stiffness is decreased by regular exercise, and increased nitric oxide (NO) production participates in this effect. Apelin regulates endothelial NO synthase in endothelial cells, promoting NO production. However, the effect of aerobic exercise training on circ...

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Autores principales:	Shumpei Fujie, Koji Sato, Eri Miyamoto-Mikami, Natsuki Hasegawa, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f839bfdb33f049eb8a889d98d649a451
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spelling	oai:doaj.org-article:f839bfdb33f049eb8a889d98d649a4512021-11-18T08:25:29ZReduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.1932-620310.1371/journal.pone.0093545https://doaj.org/article/f839bfdb33f049eb8a889d98d649a4512014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24691252/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Aging-induced deterioration of arterial stiffness is decreased by regular exercise, and increased nitric oxide (NO) production participates in this effect. Apelin regulates endothelial NO synthase in endothelial cells, promoting NO production. However, the effect of aerobic exercise training on circulating apelin levels in healthy middle-aged and older adults remains unknown. Accordingly, this study aimed to clarify the effects of regular aerobic exercise on apelin concentrations in middle-aged and older adults. Thirty-four healthy middle-aged and older subjects (67.0 ± 1.3 years) were randomly divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise training (60-70% peak oxygen uptake [VO2peak] for 45 min, 3 days/week). Before and after the intervention, we evaluated plasma apelin and nitrite/nitrate (NOx) concentrations, VO2peak, and arterial stiffness index. In the training group, VO2peak was significantly increased, and carotid β-stiffness was significantly decreased, after the intervention (P<0.05). Moreover, plasma apelin and NOx levels were significantly increased in the training group after the intervention (P<0.05). Additionally, there was a correlation between the training effects of plasma apelin levels and carotidβ-stiffness (r = -0.508, P = 0.032) and plasma NOx levels (r = 0.494, P = 0.037). By contrast, none of these parameters changed significantly in the control group. These results suggest that the increased in plasma apelin levels may be associated with exercise training-induced alternation of arterial stiffness in middle-aged and older adults.Shumpei FujieKoji SatoEri Miyamoto-MikamiNatsuki HasegawaSatoshi FujitaKiyoshi SanadaTakafumi HamaokaMotoyuki IemitsuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e93545 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shumpei Fujie Koji Sato Eri Miyamoto-Mikami Natsuki Hasegawa Satoshi Fujita Kiyoshi Sanada Takafumi Hamaoka Motoyuki Iemitsu Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.
description	Aging-induced deterioration of arterial stiffness is decreased by regular exercise, and increased nitric oxide (NO) production participates in this effect. Apelin regulates endothelial NO synthase in endothelial cells, promoting NO production. However, the effect of aerobic exercise training on circulating apelin levels in healthy middle-aged and older adults remains unknown. Accordingly, this study aimed to clarify the effects of regular aerobic exercise on apelin concentrations in middle-aged and older adults. Thirty-four healthy middle-aged and older subjects (67.0 ± 1.3 years) were randomly divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise training (60-70% peak oxygen uptake [VO2peak] for 45 min, 3 days/week). Before and after the intervention, we evaluated plasma apelin and nitrite/nitrate (NOx) concentrations, VO2peak, and arterial stiffness index. In the training group, VO2peak was significantly increased, and carotid β-stiffness was significantly decreased, after the intervention (P<0.05). Moreover, plasma apelin and NOx levels were significantly increased in the training group after the intervention (P<0.05). Additionally, there was a correlation between the training effects of plasma apelin levels and carotidβ-stiffness (r = -0.508, P = 0.032) and plasma NOx levels (r = 0.494, P = 0.037). By contrast, none of these parameters changed significantly in the control group. These results suggest that the increased in plasma apelin levels may be associated with exercise training-induced alternation of arterial stiffness in middle-aged and older adults.
format	article
author	Shumpei Fujie Koji Sato Eri Miyamoto-Mikami Natsuki Hasegawa Satoshi Fujita Kiyoshi Sanada Takafumi Hamaoka Motoyuki Iemitsu
author_facet	Shumpei Fujie Koji Sato Eri Miyamoto-Mikami Natsuki Hasegawa Satoshi Fujita Kiyoshi Sanada Takafumi Hamaoka Motoyuki Iemitsu
author_sort	Shumpei Fujie
title	Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.
title_short	Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.
title_full	Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.
title_fullStr	Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.
title_full_unstemmed	Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.
title_sort	reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/f839bfdb33f049eb8a889d98d649a451
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Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.

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