Trajectories of body mass index and risk for coronary heart disease: A 38-year follow-up study.

<h4>Objective</h4>Obesity is a well-known risk factor for coronary heart disease (CHD), but there is little evidence on the effect of long-term trajectories of body mass index (BMI) over the life course. By using repeated assessments, the aim was to study the risk of CHD in adults during...

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Autores principales:	Susanna Calling, Sven-Erik Johansson, Veronica Milos Nymberg, Jan Sundquist, Kristina Sundquist
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f843c2bf96a64bc293503f806dd90410
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spelling	oai:doaj.org-article:f843c2bf96a64bc293503f806dd904102021-12-02T20:17:11ZTrajectories of body mass index and risk for coronary heart disease: A 38-year follow-up study.1932-620310.1371/journal.pone.0258395https://doaj.org/article/f843c2bf96a64bc293503f806dd904102021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258395https://doaj.org/toc/1932-6203<h4>Objective</h4>Obesity is a well-known risk factor for coronary heart disease (CHD), but there is little evidence on the effect of long-term trajectories of body mass index (BMI) over the life course. By using repeated assessments, the aim was to study the risk of CHD in adults during 38 years in different trajectories of BMI.<h4>Methods</h4>A sample of 2129 men and women, aged 20-59 years at baseline, took part in four repeated interviews between 1980 and 2005. Data on BMI, medical history, lifestyle and socioeconomy were collected. Based on the World Health Organization categories of BMI, life course trajectories of stable normal weight, stable overweight, stable obesity, increasing BMI and fluctuating BMI were created. The individuals were followed through national registers for first hospitalization of CHD (389 events) until the end of 2017, and Hazard Ratios (HRs) were calculated, adjusted for age, sex, socioeconomic factors, lifestyle factors and metabolic comorbidities.<h4>Results</h4>Stable normal weight in all assessments was the reference group. Those who had an increase in BMI from normal weight in the first assessment to overweight or obesity in later assessments had no increased risk of CHD, HR 1.04 (95% CI: 0.70-1.53). The HR for individuals with fluctuating BMI was 1.25 (0.97-1.61), for stable overweight 1.43 (1.03-1.98), for stable obesity 1.50 (0.92-2.55), and for stable overweight or obesity 1.45 (1.07-1.97), after full adjustments.<h4>Conclusion</h4>Having a stable overweight or obesity throughout adult life was associated with increased CHD risk but changing from normal weight at baseline to overweight or obesity was not associated with increased CHD risk. Prevention of obesity early in life may be particularly important to reduce CHD risk.Susanna CallingSven-Erik JohanssonVeronica Milos NymbergJan SundquistKristina SundquistPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258395 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susanna Calling Sven-Erik Johansson Veronica Milos Nymberg Jan Sundquist Kristina Sundquist Trajectories of body mass index and risk for coronary heart disease: A 38-year follow-up study.
description	<h4>Objective</h4>Obesity is a well-known risk factor for coronary heart disease (CHD), but there is little evidence on the effect of long-term trajectories of body mass index (BMI) over the life course. By using repeated assessments, the aim was to study the risk of CHD in adults during 38 years in different trajectories of BMI.<h4>Methods</h4>A sample of 2129 men and women, aged 20-59 years at baseline, took part in four repeated interviews between 1980 and 2005. Data on BMI, medical history, lifestyle and socioeconomy were collected. Based on the World Health Organization categories of BMI, life course trajectories of stable normal weight, stable overweight, stable obesity, increasing BMI and fluctuating BMI were created. The individuals were followed through national registers for first hospitalization of CHD (389 events) until the end of 2017, and Hazard Ratios (HRs) were calculated, adjusted for age, sex, socioeconomic factors, lifestyle factors and metabolic comorbidities.<h4>Results</h4>Stable normal weight in all assessments was the reference group. Those who had an increase in BMI from normal weight in the first assessment to overweight or obesity in later assessments had no increased risk of CHD, HR 1.04 (95% CI: 0.70-1.53). The HR for individuals with fluctuating BMI was 1.25 (0.97-1.61), for stable overweight 1.43 (1.03-1.98), for stable obesity 1.50 (0.92-2.55), and for stable overweight or obesity 1.45 (1.07-1.97), after full adjustments.<h4>Conclusion</h4>Having a stable overweight or obesity throughout adult life was associated with increased CHD risk but changing from normal weight at baseline to overweight or obesity was not associated with increased CHD risk. Prevention of obesity early in life may be particularly important to reduce CHD risk.
format	article
author	Susanna Calling Sven-Erik Johansson Veronica Milos Nymberg Jan Sundquist Kristina Sundquist
author_facet	Susanna Calling Sven-Erik Johansson Veronica Milos Nymberg Jan Sundquist Kristina Sundquist
author_sort	Susanna Calling
title	Trajectories of body mass index and risk for coronary heart disease: A 38-year follow-up study.
title_short	Trajectories of body mass index and risk for coronary heart disease: A 38-year follow-up study.
title_full	Trajectories of body mass index and risk for coronary heart disease: A 38-year follow-up study.
title_fullStr	Trajectories of body mass index and risk for coronary heart disease: A 38-year follow-up study.
title_full_unstemmed	Trajectories of body mass index and risk for coronary heart disease: A 38-year follow-up study.
title_sort	trajectories of body mass index and risk for coronary heart disease: a 38-year follow-up study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f843c2bf96a64bc293503f806dd90410
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Trajectories of body mass index and risk for coronary heart disease: A 38-year follow-up study.

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