Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system

Abstract Porhyromonas gingivalis, a causative bacterium of periodontitis, is implicated in the etiology of rheumatoid arthritis (RA), mainly because of expressing peptidyl arginine deiminase (PAD) that generates RA-related autoantigens. However, compared with other periodontopathic bacteria, the pre...

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Main Authors: Keisuke Sato, Naoki Takahashi, Tamotsu Kato, Yumi Matsuda, Mai Yokoji, Miki Yamada, Takako Nakajima, Naoki Kondo, Naoto Endo, Reiko Yamamoto, Yuichiro Noiri, Hiroshi Ohno, Kazuhisa Yamazaki
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
R
Q
Online Access:https://doaj.org/article/f84459cd247f4b6fb9cb1fd2ed03ea80
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