The effect of changes in cardiovascular activity on corneal biomechanics and pulsation in rabbits

Abstract The aim was to assess the relationships between cardiovascular activity, corneal pulse characteristics, and corneal biomechanics in rabbits. Seventeen rabbits were randomly assigned to one of two anesthetic regimens to induce differences in arterial blood pressure and heart rate. Experiment...

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Autores principales:	Agnieszka Antończyk, Dominika Kubiak-Nowak, Wojciech Borawski, Zdzisław Kiełbowicz, Monika E. Danielewska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8460c378b334620b79f5f6261a34a88
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spelling	oai:doaj.org-article:f8460c378b334620b79f5f6261a34a882021-12-02T12:40:41ZThe effect of changes in cardiovascular activity on corneal biomechanics and pulsation in rabbits10.1038/s41598-020-79219-92045-2322https://doaj.org/article/f8460c378b334620b79f5f6261a34a882020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79219-9https://doaj.org/toc/2045-2322Abstract The aim was to assess the relationships between cardiovascular activity, corneal pulse characteristics, and corneal biomechanics in rabbits. Seventeen rabbits were randomly assigned to one of two anesthetic regimens to induce differences in arterial blood pressure and heart rate. Experimental protocol included measuring blood flow parameters in the ophthalmic artery by color Doppler imaging, corneal biomechanical parameters using a non-contact tonometer Corvis ST, and the corneal pulse (CP) signal using a non-contact ultrasonic technique. Statistically significantly lower mean values of normalized amplitudes of higher CP harmonics and changes in eight of the twelve corneal biomechanical parameters were observed in the rabbit group with lower arterial blood pressure and higher heart rate, intraocular pressure, and resistive index. The results of partial correlations showed that the CP signal energy and amplitude of its first harmonic correlate with the resistive index, diastolic and mean arterial pressures, whereas no statistically significant correlation was found between any of the CP parameters and intraocular pressure. Our pilot study indicates, for the first time, that non-contact and continuous measuring of corneal pulse allows indirectly assessing changes in cardiovascular activity when the confounding effect of intraocular pressure is eliminated.Agnieszka AntończykDominika Kubiak-NowakWojciech BorawskiZdzisław KiełbowiczMonika E. DanielewskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Agnieszka Antończyk Dominika Kubiak-Nowak Wojciech Borawski Zdzisław Kiełbowicz Monika E. Danielewska The effect of changes in cardiovascular activity on corneal biomechanics and pulsation in rabbits
description	Abstract The aim was to assess the relationships between cardiovascular activity, corneal pulse characteristics, and corneal biomechanics in rabbits. Seventeen rabbits were randomly assigned to one of two anesthetic regimens to induce differences in arterial blood pressure and heart rate. Experimental protocol included measuring blood flow parameters in the ophthalmic artery by color Doppler imaging, corneal biomechanical parameters using a non-contact tonometer Corvis ST, and the corneal pulse (CP) signal using a non-contact ultrasonic technique. Statistically significantly lower mean values of normalized amplitudes of higher CP harmonics and changes in eight of the twelve corneal biomechanical parameters were observed in the rabbit group with lower arterial blood pressure and higher heart rate, intraocular pressure, and resistive index. The results of partial correlations showed that the CP signal energy and amplitude of its first harmonic correlate with the resistive index, diastolic and mean arterial pressures, whereas no statistically significant correlation was found between any of the CP parameters and intraocular pressure. Our pilot study indicates, for the first time, that non-contact and continuous measuring of corneal pulse allows indirectly assessing changes in cardiovascular activity when the confounding effect of intraocular pressure is eliminated.
format	article
author	Agnieszka Antończyk Dominika Kubiak-Nowak Wojciech Borawski Zdzisław Kiełbowicz Monika E. Danielewska
author_facet	Agnieszka Antończyk Dominika Kubiak-Nowak Wojciech Borawski Zdzisław Kiełbowicz Monika E. Danielewska
author_sort	Agnieszka Antończyk
title	The effect of changes in cardiovascular activity on corneal biomechanics and pulsation in rabbits
title_short	The effect of changes in cardiovascular activity on corneal biomechanics and pulsation in rabbits
title_full	The effect of changes in cardiovascular activity on corneal biomechanics and pulsation in rabbits
title_fullStr	The effect of changes in cardiovascular activity on corneal biomechanics and pulsation in rabbits
title_full_unstemmed	The effect of changes in cardiovascular activity on corneal biomechanics and pulsation in rabbits
title_sort	effect of changes in cardiovascular activity on corneal biomechanics and pulsation in rabbits
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f8460c378b334620b79f5f6261a34a88
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The effect of changes in cardiovascular activity on corneal biomechanics and pulsation in rabbits

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