The AURORA pilot study for molecular screening of patients with advanced breast cancer–a study of the breast international group

Molecular screening: Multinational testing doable, but technical challenges remain A pilot study demonstrated that a large-scale, international screening programme for women with metastatic breast cancer is feasible. The study, coordinated by the Institut Jules Bordet and the Breast International Gr...

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Autores principales:	Marion Maetens, David Brown, Alexandre Irrthum, Philippe Aftimos, Giuseppe Viale, Sibylle Loibl, Jean-François Laes, Peter J. Campbell, Alastair Thompson, Javier Cortes, Sabine Seiler, Sara Vinnicombe, Mafalda Oliveira, Françoise Rothé, Yacine Bareche, Debora Fumagalli, Dimitrios Zardavas, Christine Desmedt, Martine Piccart, Sherene Loi, Christos Sotiriou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f8462052d39a42d18d1d361021e2031f
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spelling	oai:doaj.org-article:f8462052d39a42d18d1d361021e2031f2021-12-02T12:30:31ZThe AURORA pilot study for molecular screening of patients with advanced breast cancer–a study of the breast international group10.1038/s41523-017-0026-62374-4677https://doaj.org/article/f8462052d39a42d18d1d361021e2031f2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0026-6https://doaj.org/toc/2374-4677Molecular screening: Multinational testing doable, but technical challenges remain A pilot study demonstrated that a large-scale, international screening programme for women with metastatic breast cancer is feasible. The study, coordinated by the Institut Jules Bordet and the Breast International Group, aimed to determine whether biopsies and blood could be collected from women with metastatic breast cancer across Europe and sent to a central laboratory for targeted gene sequencing. Genetic information was successfully obtained for 26 of the 41 participants, 19 of whom had mutations that could be targeted with a known drug, potentially influencing treatment decision-making. They concluded that genomic testing is logistically ready for international molecular screening in routine clinical settings laying the groundwork for the parent European AURORA molecular screening programme which aims at recruiting 1300 metastatic breast cancer patients. However, technical challenges remain to be addressed to ensure the accuracy and robustness across different sequencing platforms.Marion MaetensDavid BrownAlexandre IrrthumPhilippe AftimosGiuseppe VialeSibylle LoiblJean-François LaesPeter J. CampbellAlastair ThompsonJavier CortesSabine SeilerSara VinnicombeMafalda OliveiraFrançoise RothéYacine BarecheDebora FumagalliDimitrios ZardavasChristine DesmedtMartine PiccartSherene LoiChristos SotiriouNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Marion Maetens David Brown Alexandre Irrthum Philippe Aftimos Giuseppe Viale Sibylle Loibl Jean-François Laes Peter J. Campbell Alastair Thompson Javier Cortes Sabine Seiler Sara Vinnicombe Mafalda Oliveira Françoise Rothé Yacine Bareche Debora Fumagalli Dimitrios Zardavas Christine Desmedt Martine Piccart Sherene Loi Christos Sotiriou The AURORA pilot study for molecular screening of patients with advanced breast cancer–a study of the breast international group
description	Molecular screening: Multinational testing doable, but technical challenges remain A pilot study demonstrated that a large-scale, international screening programme for women with metastatic breast cancer is feasible. The study, coordinated by the Institut Jules Bordet and the Breast International Group, aimed to determine whether biopsies and blood could be collected from women with metastatic breast cancer across Europe and sent to a central laboratory for targeted gene sequencing. Genetic information was successfully obtained for 26 of the 41 participants, 19 of whom had mutations that could be targeted with a known drug, potentially influencing treatment decision-making. They concluded that genomic testing is logistically ready for international molecular screening in routine clinical settings laying the groundwork for the parent European AURORA molecular screening programme which aims at recruiting 1300 metastatic breast cancer patients. However, technical challenges remain to be addressed to ensure the accuracy and robustness across different sequencing platforms.
format	article
author	Marion Maetens David Brown Alexandre Irrthum Philippe Aftimos Giuseppe Viale Sibylle Loibl Jean-François Laes Peter J. Campbell Alastair Thompson Javier Cortes Sabine Seiler Sara Vinnicombe Mafalda Oliveira Françoise Rothé Yacine Bareche Debora Fumagalli Dimitrios Zardavas Christine Desmedt Martine Piccart Sherene Loi Christos Sotiriou
author_facet	Marion Maetens David Brown Alexandre Irrthum Philippe Aftimos Giuseppe Viale Sibylle Loibl Jean-François Laes Peter J. Campbell Alastair Thompson Javier Cortes Sabine Seiler Sara Vinnicombe Mafalda Oliveira Françoise Rothé Yacine Bareche Debora Fumagalli Dimitrios Zardavas Christine Desmedt Martine Piccart Sherene Loi Christos Sotiriou
author_sort	Marion Maetens
title	The AURORA pilot study for molecular screening of patients with advanced breast cancer–a study of the breast international group
title_short	The AURORA pilot study for molecular screening of patients with advanced breast cancer–a study of the breast international group
title_full	The AURORA pilot study for molecular screening of patients with advanced breast cancer–a study of the breast international group
title_fullStr	The AURORA pilot study for molecular screening of patients with advanced breast cancer–a study of the breast international group
title_full_unstemmed	The AURORA pilot study for molecular screening of patients with advanced breast cancer–a study of the breast international group
title_sort	aurora pilot study for molecular screening of patients with advanced breast cancer–a study of the breast international group
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f8462052d39a42d18d1d361021e2031f
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The AURORA pilot study for molecular screening of patients with advanced breast cancer–a study of the breast international group

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