Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening

Yongyuan Guo,1,* Beibei Hu,2,* Chu Tang,1 Yunpeng Wu,1 Pengfei Sun,1 Xianlong Zhang,3 Yuhua Jia1 1Orthopaedic Department, 2Medical Examination Center, Qilu Hospital of Shandong University, Jinan, 3Orthopaedic Department, The Sixth Affiliated People’s Hospital, Medical School of&a...

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Autores principales:	Guo Y, Hu B, Tang C, Wu Y, Sun P, Zhang X, Jia Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f848decb93ea4b2b9211189819c90df8
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spelling	oai:doaj.org-article:f848decb93ea4b2b9211189819c90df82021-12-02T05:09:41ZIncreased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening1178-2013https://doaj.org/article/f848decb93ea4b2b9211189819c90df82015-07-01T00:00:00Zhttp://www.dovepress.com/increased-osteoblast-function-in-vitro-and-in-vivo-through-surface-nan-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yongyuan Guo,1,* Beibei Hu,2,* Chu Tang,1 Yunpeng Wu,1 Pengfei Sun,1 Xianlong Zhang,3 Yuhua Jia1 1Orthopaedic Department, 2Medical Examination Center, Qilu Hospital of Shandong University, Jinan, 3Orthopaedic Department, The Sixth Affiliated People’s Hospital, Medical School of Shanghai Jiao Tong University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Surface topography has significant influence on good and fast osseointegration of biomedical implants. In this work, ultrasonic shot peening was conducted to modify titanium to produce nanograined (NG) surface. Its ability to induce new bone formation was evaluated using an in vivo animal model. We demonstrated that the NG surface enhanced osteoblast adhesion, proliferation, differentiation, and mineralization in in vitro experiments compared to coarse-grained titanium surface. Push-out test, histological observations, fluorescent labeling, and histomorphometrical analysis consistently indicated that the NG surfaces developed have the higher osseointegration than coarse-grained surfaces. Those results suggest that ultrasonic shot peening has the potential for future use as a surface modification method in biomedical application. Keywords: ultrasonic shot peening, titanium, in vivo, osseointegerationGuo YHu BTang CWu YSun PZhang XJia YDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4593-4603 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Guo Y Hu B Tang C Wu Y Sun P Zhang X Jia Y Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
description	Yongyuan Guo,1,* Beibei Hu,2,* Chu Tang,1 Yunpeng Wu,1 Pengfei Sun,1 Xianlong Zhang,3 Yuhua Jia1 1Orthopaedic Department, 2Medical Examination Center, Qilu Hospital of Shandong University, Jinan, 3Orthopaedic Department, The Sixth Affiliated People’s Hospital, Medical School of Shanghai Jiao Tong University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Surface topography has significant influence on good and fast osseointegration of biomedical implants. In this work, ultrasonic shot peening was conducted to modify titanium to produce nanograined (NG) surface. Its ability to induce new bone formation was evaluated using an in vivo animal model. We demonstrated that the NG surface enhanced osteoblast adhesion, proliferation, differentiation, and mineralization in in vitro experiments compared to coarse-grained titanium surface. Push-out test, histological observations, fluorescent labeling, and histomorphometrical analysis consistently indicated that the NG surfaces developed have the higher osseointegration than coarse-grained surfaces. Those results suggest that ultrasonic shot peening has the potential for future use as a surface modification method in biomedical application. Keywords: ultrasonic shot peening, titanium, in vivo, osseointegeration
format	article
author	Guo Y Hu B Tang C Wu Y Sun P Zhang X Jia Y
author_facet	Guo Y Hu B Tang C Wu Y Sun P Zhang X Jia Y
author_sort	Guo Y
title	Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
title_short	Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
title_full	Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
title_fullStr	Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
title_full_unstemmed	Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
title_sort	increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/f848decb93ea4b2b9211189819c90df8
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Increased osteoblast function in vitro and in vivo through surface nanostructuring by ultrasonic shot peening

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