Examination of Age-Related Retinal Vascular Changes in the Macula Using Optical Coherence Tomography Angiography of the Eyes After Cataract Surgery

Yuji Yoshikawa, Takuhei Shoji, Junji Kanno, Hisashi Ibuki, Kimitake Ozaki, Hirokazu Ishii, Hiromi Inami, Kei Shinoda Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, JapanCorrespondence: Kei ShinodaDepartment of Ophthalmology, Saitama Medical University, 350-0495 Morohogo 38,...

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Autores principales:	Yoshikawa Y, Shoji T, Kanno J, Ibuki H, Ozaki K, Ishii H, Inami H, Shinoda K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	optical coherence tomography angiography macular vessel density foveal avascular zone aging cataract surgery Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f84d009a542a4f1b806c9d9c2883cd94
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spelling	oai:doaj.org-article:f84d009a542a4f1b806c9d9c2883cd942021-12-02T16:34:31ZExamination of Age-Related Retinal Vascular Changes in the Macula Using Optical Coherence Tomography Angiography of the Eyes After Cataract Surgery1177-5483https://doaj.org/article/f84d009a542a4f1b806c9d9c2883cd942021-09-01T00:00:00Zhttps://www.dovepress.com/examination-of-age-related-retinal-vascular-changes-in-the-macula-usin-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Yuji Yoshikawa, Takuhei Shoji, Junji Kanno, Hisashi Ibuki, Kimitake Ozaki, Hirokazu Ishii, Hiromi Inami, Kei Shinoda Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, JapanCorrespondence: Kei ShinodaDepartment of Ophthalmology, Saitama Medical University, 350-0495 Morohogo 38, Iruma, Saitama, JapanTel +81 49-276-1250Fax +81 49-295-8002Email shinodak@med.teikyo-u.ac.jpPurpose: Optical coherence tomography angiography (OCTA) allows noninvasive observation of the retinal vasculature, and image analysis can be used to calculate the retinal vessel density and foveal avascular zone (FAZ) area. A previous study showed that macular vessel density and the signal strength index (SSI) of OCTA images increased significantly after cataract surgery. However, the effect of aging on OCTA analysis remains unclear. This study aimed to investigate age-related changes in macular vascularization while excluding the effects of cataracts.Patients and Methods: OCTA imaging of the macula was performed in adult patients who had undergone cataract surgery between February 2018 and May 2019 and in young healthy participants between April 2017 and April 2018.Results: The median (quartiles) age of the overall study population was 59.0 (27.0, 69.0) years, and no severe refractive error was observed (axial length: 24.2 ± 1.3 [mean ± SD] mm; spherical equivalent: 0.75 [− 2.25, 0.00] diopter). When we investigated the relationship between macular vessel density and age after excluding the effects of cataracts, we found that the macular vessel density showed age-related changes even in the absence of the effects of the SSI. However, the FAZ area was not affected by age.Conclusion: Macular vessel density decreased with age, even when the effects of cataracts were excluded. The effects of age and cataracts should be considered when designing studies and interpreting OCTA findings of the retinal vasculature.Keywords: optical coherence tomography angiography, macular vessel density, foveal avascular zone, aging, cataract surgeryYoshikawa YShoji TKanno JIbuki HOzaki KIshii HInami HShinoda KDove Medical Pressarticleoptical coherence tomography angiographymacular vessel densityfoveal avascular zoneagingcataract surgeryOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 3687-3695 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	optical coherence tomography angiography macular vessel density foveal avascular zone aging cataract surgery Ophthalmology RE1-994
spellingShingle	optical coherence tomography angiography macular vessel density foveal avascular zone aging cataract surgery Ophthalmology RE1-994 Yoshikawa Y Shoji T Kanno J Ibuki H Ozaki K Ishii H Inami H Shinoda K Examination of Age-Related Retinal Vascular Changes in the Macula Using Optical Coherence Tomography Angiography of the Eyes After Cataract Surgery
description	Yuji Yoshikawa, Takuhei Shoji, Junji Kanno, Hisashi Ibuki, Kimitake Ozaki, Hirokazu Ishii, Hiromi Inami, Kei Shinoda Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, JapanCorrespondence: Kei ShinodaDepartment of Ophthalmology, Saitama Medical University, 350-0495 Morohogo 38, Iruma, Saitama, JapanTel +81 49-276-1250Fax +81 49-295-8002Email shinodak@med.teikyo-u.ac.jpPurpose: Optical coherence tomography angiography (OCTA) allows noninvasive observation of the retinal vasculature, and image analysis can be used to calculate the retinal vessel density and foveal avascular zone (FAZ) area. A previous study showed that macular vessel density and the signal strength index (SSI) of OCTA images increased significantly after cataract surgery. However, the effect of aging on OCTA analysis remains unclear. This study aimed to investigate age-related changes in macular vascularization while excluding the effects of cataracts.Patients and Methods: OCTA imaging of the macula was performed in adult patients who had undergone cataract surgery between February 2018 and May 2019 and in young healthy participants between April 2017 and April 2018.Results: The median (quartiles) age of the overall study population was 59.0 (27.0, 69.0) years, and no severe refractive error was observed (axial length: 24.2 ± 1.3 [mean ± SD] mm; spherical equivalent: 0.75 [− 2.25, 0.00] diopter). When we investigated the relationship between macular vessel density and age after excluding the effects of cataracts, we found that the macular vessel density showed age-related changes even in the absence of the effects of the SSI. However, the FAZ area was not affected by age.Conclusion: Macular vessel density decreased with age, even when the effects of cataracts were excluded. The effects of age and cataracts should be considered when designing studies and interpreting OCTA findings of the retinal vasculature.Keywords: optical coherence tomography angiography, macular vessel density, foveal avascular zone, aging, cataract surgery
format	article
author	Yoshikawa Y Shoji T Kanno J Ibuki H Ozaki K Ishii H Inami H Shinoda K
author_facet	Yoshikawa Y Shoji T Kanno J Ibuki H Ozaki K Ishii H Inami H Shinoda K
author_sort	Yoshikawa Y
title	Examination of Age-Related Retinal Vascular Changes in the Macula Using Optical Coherence Tomography Angiography of the Eyes After Cataract Surgery
title_short	Examination of Age-Related Retinal Vascular Changes in the Macula Using Optical Coherence Tomography Angiography of the Eyes After Cataract Surgery
title_full	Examination of Age-Related Retinal Vascular Changes in the Macula Using Optical Coherence Tomography Angiography of the Eyes After Cataract Surgery
title_fullStr	Examination of Age-Related Retinal Vascular Changes in the Macula Using Optical Coherence Tomography Angiography of the Eyes After Cataract Surgery
title_full_unstemmed	Examination of Age-Related Retinal Vascular Changes in the Macula Using Optical Coherence Tomography Angiography of the Eyes After Cataract Surgery
title_sort	examination of age-related retinal vascular changes in the macula using optical coherence tomography angiography of the eyes after cataract surgery
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f84d009a542a4f1b806c9d9c2883cd94
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Examination of Age-Related Retinal Vascular Changes in the Macula Using Optical Coherence Tomography Angiography of the Eyes After Cataract Surgery

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