Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection

Anti-retroviral treatment does not fully resolve mucosal dysfunction and systemic inflammation in HIV infected individuals. Authors show here that an unusual population of regulatory T cells, distinguished by Amphiregulin expression and the incapability to suppress CD4 T cells might contribute to di...

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Autores principales:	N. Bhaskaran, E. Schneider, F. Faddoul, A. Paes da Silva, R. Asaad, A. Talla, N. Greenspan, A. D. Levine, D. McDonald, J. Karn, M. M. Lederman, P. Pandiyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f84dc4b52eef4e9586846ddf93c4213d
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spelling	oai:doaj.org-article:f84dc4b52eef4e9586846ddf93c4213d2021-12-02T16:35:13ZOral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection10.1038/s41467-021-25340-w2041-1723https://doaj.org/article/f84dc4b52eef4e9586846ddf93c4213d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25340-whttps://doaj.org/toc/2041-1723Anti-retroviral treatment does not fully resolve mucosal dysfunction and systemic inflammation in HIV infected individuals. Authors show here that an unusual population of regulatory T cells, distinguished by Amphiregulin expression and the incapability to suppress CD4 T cells might contribute to disrupted oral immune protection in HIV patients.N. BhaskaranE. SchneiderF. FaddoulA. Paes da SilvaR. AsaadA. TallaN. GreenspanA. D. LevineD. McDonaldJ. KarnM. M. LedermanP. PandiyanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q N. Bhaskaran E. Schneider F. Faddoul A. Paes da Silva R. Asaad A. Talla N. Greenspan A. D. Levine D. McDonald J. Karn M. M. Lederman P. Pandiyan Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection
description	Anti-retroviral treatment does not fully resolve mucosal dysfunction and systemic inflammation in HIV infected individuals. Authors show here that an unusual population of regulatory T cells, distinguished by Amphiregulin expression and the incapability to suppress CD4 T cells might contribute to disrupted oral immune protection in HIV patients.
format	article
author	N. Bhaskaran E. Schneider F. Faddoul A. Paes da Silva R. Asaad A. Talla N. Greenspan A. D. Levine D. McDonald J. Karn M. M. Lederman P. Pandiyan
author_facet	N. Bhaskaran E. Schneider F. Faddoul A. Paes da Silva R. Asaad A. Talla N. Greenspan A. D. Levine D. McDonald J. Karn M. M. Lederman P. Pandiyan
author_sort	N. Bhaskaran
title	Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection
title_short	Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection
title_full	Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection
title_fullStr	Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection
title_full_unstemmed	Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection
title_sort	oral immune dysfunction is associated with the expansion of foxp3+pd-1+amphiregulin+ t cells during hiv infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f84dc4b52eef4e9586846ddf93c4213d
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Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection

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