Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion

Cai et al discover an auto-inhibitory interaction between the S5 and S6 helices in the calcium-selective channel TRPV6. Molecular dynamics simulations predict that pathogenic mutation R532Q in S5 results in channel gain-of-function, which is confirmed in breast cancer migration, invasion and apoptos...

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Auteurs principaux:	Ruiqi Cai, Lingyun Wang, Xiong Liu, Marek Michalak, Jingfeng Tang, Ji-Bin Peng, Xing-Zhen Chen
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/f84f1128838c439088a25fe4a20a4f1e
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spelling	oai:doaj.org-article:f84f1128838c439088a25fe4a20a4f1e2021-12-02T15:10:38ZAuto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion10.1038/s42003-021-02521-32399-3642https://doaj.org/article/f84f1128838c439088a25fe4a20a4f1e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02521-3https://doaj.org/toc/2399-3642Cai et al discover an auto-inhibitory interaction between the S5 and S6 helices in the calcium-selective channel TRPV6. Molecular dynamics simulations predict that pathogenic mutation R532Q in S5 results in channel gain-of-function, which is confirmed in breast cancer migration, invasion and apoptosis assays.Ruiqi CaiLingyun WangXiong LiuMarek MichalakJingfeng TangJi-Bin PengXing-Zhen ChenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ruiqi Cai Lingyun Wang Xiong Liu Marek Michalak Jingfeng Tang Ji-Bin Peng Xing-Zhen Chen Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
description	Cai et al discover an auto-inhibitory interaction between the S5 and S6 helices in the calcium-selective channel TRPV6. Molecular dynamics simulations predict that pathogenic mutation R532Q in S5 results in channel gain-of-function, which is confirmed in breast cancer migration, invasion and apoptosis assays.
format	article
author	Ruiqi Cai Lingyun Wang Xiong Liu Marek Michalak Jingfeng Tang Ji-Bin Peng Xing-Zhen Chen
author_facet	Ruiqi Cai Lingyun Wang Xiong Liu Marek Michalak Jingfeng Tang Ji-Bin Peng Xing-Zhen Chen
author_sort	Ruiqi Cai
title	Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
title_short	Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
title_full	Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
title_fullStr	Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
title_full_unstemmed	Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion
title_sort	auto-inhibitory intramolecular s5/s6 interaction in the trpv6 channel regulates breast cancer cell migration and invasion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f84f1128838c439088a25fe4a20a4f1e
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Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion

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