Precise tuning of gene expression levels in mammalian cells

Analogue regulation of gene expression is important for normal function in mammals but existing genetic technologies are designed to achieve ON/OFF control. Here the authors develop synthetic microRNA silencing-mediated fine-tuners (miSFITs) to precisely control target gene expression levels.

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Autores principales:	Yale S. Michaels, Mike B. Barnkob, Hector Barbosa, Toni A. Baeumler, Mary K. Thompson, Violaine Andre, Huw Colin-York, Marco Fritzsche, Uzi Gileadi, Hilary M. Sheppard, David J. H. F. Knapp, Thomas A. Milne, Vincenzo Cerundolo, Tudor A. Fulga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f84f595575f647518a682f40b466a3e0
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spelling	oai:doaj.org-article:f84f595575f647518a682f40b466a3e02021-12-02T16:58:16ZPrecise tuning of gene expression levels in mammalian cells10.1038/s41467-019-08777-y2041-1723https://doaj.org/article/f84f595575f647518a682f40b466a3e02019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08777-yhttps://doaj.org/toc/2041-1723Analogue regulation of gene expression is important for normal function in mammals but existing genetic technologies are designed to achieve ON/OFF control. Here the authors develop synthetic microRNA silencing-mediated fine-tuners (miSFITs) to precisely control target gene expression levels.Yale S. MichaelsMike B. BarnkobHector BarbosaToni A. BaeumlerMary K. ThompsonViolaine AndreHuw Colin-YorkMarco FritzscheUzi GileadiHilary M. SheppardDavid J. H. F. KnappThomas A. MilneVincenzo CerundoloTudor A. FulgaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yale S. Michaels Mike B. Barnkob Hector Barbosa Toni A. Baeumler Mary K. Thompson Violaine Andre Huw Colin-York Marco Fritzsche Uzi Gileadi Hilary M. Sheppard David J. H. F. Knapp Thomas A. Milne Vincenzo Cerundolo Tudor A. Fulga Precise tuning of gene expression levels in mammalian cells
description	Analogue regulation of gene expression is important for normal function in mammals but existing genetic technologies are designed to achieve ON/OFF control. Here the authors develop synthetic microRNA silencing-mediated fine-tuners (miSFITs) to precisely control target gene expression levels.
format	article
author	Yale S. Michaels Mike B. Barnkob Hector Barbosa Toni A. Baeumler Mary K. Thompson Violaine Andre Huw Colin-York Marco Fritzsche Uzi Gileadi Hilary M. Sheppard David J. H. F. Knapp Thomas A. Milne Vincenzo Cerundolo Tudor A. Fulga
author_facet	Yale S. Michaels Mike B. Barnkob Hector Barbosa Toni A. Baeumler Mary K. Thompson Violaine Andre Huw Colin-York Marco Fritzsche Uzi Gileadi Hilary M. Sheppard David J. H. F. Knapp Thomas A. Milne Vincenzo Cerundolo Tudor A. Fulga
author_sort	Yale S. Michaels
title	Precise tuning of gene expression levels in mammalian cells
title_short	Precise tuning of gene expression levels in mammalian cells
title_full	Precise tuning of gene expression levels in mammalian cells
title_fullStr	Precise tuning of gene expression levels in mammalian cells
title_full_unstemmed	Precise tuning of gene expression levels in mammalian cells
title_sort	precise tuning of gene expression levels in mammalian cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f84f595575f647518a682f40b466a3e0
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Precise tuning of gene expression levels in mammalian cells

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