Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease

Obesity: tracing the inflammation underlying liver disease A deeper understanding of the molecular processes underlying dysfunctional fatty-acid metabolism in nonalcoholic fatty liver disease (NAFLD) could help protect patients from severe liver damage. NAFLD is a common consequence of obesity, and...

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Autores principales:	Jin Young Huh, Alan R. Saltiel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/f852028ca92642ae9732d6bd0cb465ac
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spelling	oai:doaj.org-article:f852028ca92642ae9732d6bd0cb465ac2021-12-05T12:24:28ZRoles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease10.1038/s12276-021-00712-w1226-36132092-6413https://doaj.org/article/f852028ca92642ae9732d6bd0cb465ac2021-11-01T00:00:00Zhttps://doi.org/10.1038/s12276-021-00712-whttps://doaj.org/toc/1226-3613https://doaj.org/toc/2092-6413Obesity: tracing the inflammation underlying liver disease A deeper understanding of the molecular processes underlying dysfunctional fatty-acid metabolism in nonalcoholic fatty liver disease (NAFLD) could help protect patients from severe liver damage. NAFLD is a common consequence of obesity, and severe disease can ultimately give rise to liver cancer or cirrhosis. Alan Saltiel of the University of California, San Diego, USA, and Jin Young Huh of Seoul National University, South Korea, have reviewed current knowledge of the mechanisms governing fatty acid metabolism in the liver, and how they are disturbed in obesity and NAFLD. The various IκB kinase (IKK) complexes and a protein known as TANK-binding kinase 1 (TBK1) play particularly prominent roles in the inflammatory response associated with NAFLD pathogenesis. Better insights into IKK- and TBK1-associated regulatory pathways could inform the development of new interventions for this currently untreatable condition.Jin Young HuhAlan R. SaltielNature Publishing GrouparticleMedicineRBiochemistryQD415-436ENExperimental and Molecular Medicine, Vol 53, Iss 11, Pp 1697-1705 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biochemistry QD415-436
spellingShingle	Medicine R Biochemistry QD415-436 Jin Young Huh Alan R. Saltiel Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
description	Obesity: tracing the inflammation underlying liver disease A deeper understanding of the molecular processes underlying dysfunctional fatty-acid metabolism in nonalcoholic fatty liver disease (NAFLD) could help protect patients from severe liver damage. NAFLD is a common consequence of obesity, and severe disease can ultimately give rise to liver cancer or cirrhosis. Alan Saltiel of the University of California, San Diego, USA, and Jin Young Huh of Seoul National University, South Korea, have reviewed current knowledge of the mechanisms governing fatty acid metabolism in the liver, and how they are disturbed in obesity and NAFLD. The various IκB kinase (IKK) complexes and a protein known as TANK-binding kinase 1 (TBK1) play particularly prominent roles in the inflammatory response associated with NAFLD pathogenesis. Better insights into IKK- and TBK1-associated regulatory pathways could inform the development of new interventions for this currently untreatable condition.
format	article
author	Jin Young Huh Alan R. Saltiel
author_facet	Jin Young Huh Alan R. Saltiel
author_sort	Jin Young Huh
title	Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
title_short	Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
title_full	Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
title_fullStr	Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
title_full_unstemmed	Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
title_sort	roles of iκb kinases and tank-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/f852028ca92642ae9732d6bd0cb465ac
work_keys_str_mv	AT jinyounghuh rolesofikbkinasesandtankbindingkinase1inhepaticlipidmetabolismandnonalcoholicfattyliverdisease AT alanrsaltiel rolesofikbkinasesandtankbindingkinase1inhepaticlipidmetabolismandnonalcoholicfattyliverdisease
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Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease

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