Point-of-Care Diagnostic Tools for Surveillance of SARS-CoV-2 Infections

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a recently emerged and highly contagious virus that causes coronavirus disease 2019 (COVID-19). As of August 24, 2021, there were more than 212 million confirmed COVID-19 cases and nearly 4.4 million deaths reported globally. Early diag...

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Autores principales:	Dhanasekaran Sakthivel, David Delgado-Diaz, Laura McArthur, William Hopper, Jack S. Richards, Charles A. Narh
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 SARS-CoV-2 point-of-care diagnostics isothermal amplification (LAMP) sample types Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/f8521529fb8349fab6bd923ca16784f5
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spelling	oai:doaj.org-article:f8521529fb8349fab6bd923ca16784f52021-11-30T23:47:19ZPoint-of-Care Diagnostic Tools for Surveillance of SARS-CoV-2 Infections2296-256510.3389/fpubh.2021.766871https://doaj.org/article/f8521529fb8349fab6bd923ca16784f52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.766871/fullhttps://doaj.org/toc/2296-2565Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a recently emerged and highly contagious virus that causes coronavirus disease 2019 (COVID-19). As of August 24, 2021, there were more than 212 million confirmed COVID-19 cases and nearly 4.4 million deaths reported globally. Early diagnosis and isolation of infected individuals remains one of the most effective public health interventions to control SARS-CoV-2 spread and for effective clinical management of COVID-19 cases. Currently, SARS-CoV-2 infection is diagnosed presumptively based on clinical symptoms and confirmed by detecting the viral RNA in respiratory samples using reverse transcription polymerase chain reaction (RT-PCR). Standard RT-PCR protocols are time consuming, expensive, and technically demanding, which makes them a poor choice for large scale and point-of-care screening in resource-poor settings. Recently developed isothermal nucleic acid amplification tests (iNAAT), antigen and/or serological tests are cost-effective to scale COVID-19 testing at the point-of-care (PoC) and for surveillance activities. This review discusses the development of rapid PoC molecular tools for the detection and surveillance of SARS-CoV-2 infections.Dhanasekaran SakthivelDavid Delgado-DiazLaura McArthurWilliam HopperJack S. RichardsJack S. RichardsJack S. RichardsCharles A. NarhCharles A. NarhCharles A. NarhFrontiers Media S.A.articleCOVID-19SARS-CoV-2point-of-carediagnosticsisothermal amplification (LAMP)sample typesPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 point-of-care diagnostics isothermal amplification (LAMP) sample types Public aspects of medicine RA1-1270
spellingShingle	COVID-19 SARS-CoV-2 point-of-care diagnostics isothermal amplification (LAMP) sample types Public aspects of medicine RA1-1270 Dhanasekaran Sakthivel David Delgado-Diaz Laura McArthur William Hopper Jack S. Richards Jack S. Richards Jack S. Richards Charles A. Narh Charles A. Narh Charles A. Narh Point-of-Care Diagnostic Tools for Surveillance of SARS-CoV-2 Infections
description	Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a recently emerged and highly contagious virus that causes coronavirus disease 2019 (COVID-19). As of August 24, 2021, there were more than 212 million confirmed COVID-19 cases and nearly 4.4 million deaths reported globally. Early diagnosis and isolation of infected individuals remains one of the most effective public health interventions to control SARS-CoV-2 spread and for effective clinical management of COVID-19 cases. Currently, SARS-CoV-2 infection is diagnosed presumptively based on clinical symptoms and confirmed by detecting the viral RNA in respiratory samples using reverse transcription polymerase chain reaction (RT-PCR). Standard RT-PCR protocols are time consuming, expensive, and technically demanding, which makes them a poor choice for large scale and point-of-care screening in resource-poor settings. Recently developed isothermal nucleic acid amplification tests (iNAAT), antigen and/or serological tests are cost-effective to scale COVID-19 testing at the point-of-care (PoC) and for surveillance activities. This review discusses the development of rapid PoC molecular tools for the detection and surveillance of SARS-CoV-2 infections.
format	article
author	Dhanasekaran Sakthivel David Delgado-Diaz Laura McArthur William Hopper Jack S. Richards Jack S. Richards Jack S. Richards Charles A. Narh Charles A. Narh Charles A. Narh
author_facet	Dhanasekaran Sakthivel David Delgado-Diaz Laura McArthur William Hopper Jack S. Richards Jack S. Richards Jack S. Richards Charles A. Narh Charles A. Narh Charles A. Narh
author_sort	Dhanasekaran Sakthivel
title	Point-of-Care Diagnostic Tools for Surveillance of SARS-CoV-2 Infections
title_short	Point-of-Care Diagnostic Tools for Surveillance of SARS-CoV-2 Infections
title_full	Point-of-Care Diagnostic Tools for Surveillance of SARS-CoV-2 Infections
title_fullStr	Point-of-Care Diagnostic Tools for Surveillance of SARS-CoV-2 Infections
title_full_unstemmed	Point-of-Care Diagnostic Tools for Surveillance of SARS-CoV-2 Infections
title_sort	point-of-care diagnostic tools for surveillance of sars-cov-2 infections
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f8521529fb8349fab6bd923ca16784f5
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Point-of-Care Diagnostic Tools for Surveillance of SARS-CoV-2 Infections

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