RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
The Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy.
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Nature Portfolio
2020
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oai:doaj.org-article:f852a7fca4c646d8bcc24eb27d1af2302021-12-02T15:09:10ZRNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction10.1038/s41467-020-18022-62041-1723https://doaj.org/article/f852a7fca4c646d8bcc24eb27d1af2302020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18022-6https://doaj.org/toc/2041-1723The Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy.Mauro MontalbanoSalome McAllenNicha PuangmalaiUrmi SenguptaNemil BhattOmar D. JohnsonMichael G. KharasRakez KayedNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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Science Q Mauro Montalbano Salome McAllen Nicha Puangmalai Urmi Sengupta Nemil Bhatt Omar D. Johnson Michael G. Kharas Rakez Kayed RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction |
description |
The Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy. |
format |
article |
author |
Mauro Montalbano Salome McAllen Nicha Puangmalai Urmi Sengupta Nemil Bhatt Omar D. Johnson Michael G. Kharas Rakez Kayed |
author_facet |
Mauro Montalbano Salome McAllen Nicha Puangmalai Urmi Sengupta Nemil Bhatt Omar D. Johnson Michael G. Kharas Rakez Kayed |
author_sort |
Mauro Montalbano |
title |
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction |
title_short |
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction |
title_full |
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction |
title_fullStr |
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction |
title_full_unstemmed |
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction |
title_sort |
rna-binding proteins musashi and tau soluble aggregates initiate nuclear dysfunction |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/f852a7fca4c646d8bcc24eb27d1af230 |
work_keys_str_mv |
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1718387914380935168 |