RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

The Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy.

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Autores principales: Mauro Montalbano, Salome McAllen, Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Omar D. Johnson, Michael G. Kharas, Rakez Kayed
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f852a7fca4c646d8bcc24eb27d1af230
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spelling oai:doaj.org-article:f852a7fca4c646d8bcc24eb27d1af2302021-12-02T15:09:10ZRNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction10.1038/s41467-020-18022-62041-1723https://doaj.org/article/f852a7fca4c646d8bcc24eb27d1af2302020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18022-6https://doaj.org/toc/2041-1723The Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy.Mauro MontalbanoSalome McAllenNicha PuangmalaiUrmi SenguptaNemil BhattOmar D. JohnsonMichael G. KharasRakez KayedNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mauro Montalbano
Salome McAllen
Nicha Puangmalai
Urmi Sengupta
Nemil Bhatt
Omar D. Johnson
Michael G. Kharas
Rakez Kayed
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
description The Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy.
format article
author Mauro Montalbano
Salome McAllen
Nicha Puangmalai
Urmi Sengupta
Nemil Bhatt
Omar D. Johnson
Michael G. Kharas
Rakez Kayed
author_facet Mauro Montalbano
Salome McAllen
Nicha Puangmalai
Urmi Sengupta
Nemil Bhatt
Omar D. Johnson
Michael G. Kharas
Rakez Kayed
author_sort Mauro Montalbano
title RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
title_short RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
title_full RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
title_fullStr RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
title_full_unstemmed RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
title_sort rna-binding proteins musashi and tau soluble aggregates initiate nuclear dysfunction
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/f852a7fca4c646d8bcc24eb27d1af230
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