CSF1R Inhibition Combined with GM-CSF Reprograms Macrophages and Disrupts Protumoral Interplays with AML Cells

Relapse is a major issue in acute myeloid leukemia (AML) and while the contribution of gene mutations in developing drug resistance is well established, little is known on the role of macrophages (MΦs) in an AML cell microenvironment. We examined whether myeloblasts could educate MΦs to adopt a prot...

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Autores principales: Tatiana Smirnova, Caroline Spertini, Olivier Spertini
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
AML
Acceso en línea:https://doaj.org/article/f8559ad842584c5081042b14eb85a8b8
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