Physiological significance of pericoronary inflammation in epicardial functional stenosis and global coronary flow reserve

Abstract Both fractional flow reserve (FFR) and global coronary flow reserve (g-CFR) provide prognostic information in patients with stable coronary artery disease (CAD). Inflammation plays a vital role in impaired endothelial dysfunction and atherosclerotic progression, potentially predicting cardi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoshihisa Kanaji, Tomoyo Sugiyama, Masahiro Hoshino, Toru Misawa, Tatsuhiro Nagamine, Yumi Yasui, Kai Nogami, Hiroki Ueno, Hidenori Hirano, Masahiro Hada, Masao Yamaguchi, Rikuta Hamaya, Eisuke Usui, Taishi Yonetsu, Tetsuo Sasano, Tsunekazu Kakuta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8585ae5df1044e8b462d2ecdb7d5b23
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f8585ae5df1044e8b462d2ecdb7d5b23
record_format	dspace
spelling	oai:doaj.org-article:f8585ae5df1044e8b462d2ecdb7d5b232021-12-02T17:27:11ZPhysiological significance of pericoronary inflammation in epicardial functional stenosis and global coronary flow reserve10.1038/s41598-021-97849-52045-2322https://doaj.org/article/f8585ae5df1044e8b462d2ecdb7d5b232021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97849-5https://doaj.org/toc/2045-2322Abstract Both fractional flow reserve (FFR) and global coronary flow reserve (g-CFR) provide prognostic information in patients with stable coronary artery disease (CAD). Inflammation plays a vital role in impaired endothelial dysfunction and atherosclerotic progression, potentially predicting cardiovascular mortality. This study aimed to evaluate the physiological significance of pericoronary adipose tissue inflammation assessed by CT attenuation (PCATA) in epicardial functional stenosis severity and g-CFR in patients with CAD. A total of 131 CAD patients with a single de novo epicardial coronary stenosis who underwent coronary CT-angiography (CCTA), phase-contrast cine-magnetic resonance imaging (PC-CMR) and FFR measurement were studied. PCATA was assessed using the mean CT attenuation value. G-CFR was obtained by quantifying absolute coronary sinus flow (ml/min/g) by PC-CMR at rest and during maximum hyperemia. Median FFR, g-CFR, and PCATA values were 0.75, 2.59, and − 71.3, respectively. Serum creatinine, NT-proBNP, left ventricular end-diastolic volume, and PCATA were independently associated with g-CFR. PCATA showed a significant incremental predictive efficacy for impaired g-CFR (< 2.0) when added to the clinical risk model. PCATA was significantly associated with g-CFR, independent of FFR. Our results suggest the pathophysiological mechanisms linking perivascular inflammation with g-CFR in CAD patients.Yoshihisa KanajiTomoyo SugiyamaMasahiro HoshinoToru MisawaTatsuhiro NagamineYumi YasuiKai NogamiHiroki UenoHidenori HiranoMasahiro HadaMasao YamaguchiRikuta HamayaEisuke UsuiTaishi YonetsuTetsuo SasanoTsunekazu KakutaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshihisa Kanaji Tomoyo Sugiyama Masahiro Hoshino Toru Misawa Tatsuhiro Nagamine Yumi Yasui Kai Nogami Hiroki Ueno Hidenori Hirano Masahiro Hada Masao Yamaguchi Rikuta Hamaya Eisuke Usui Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta Physiological significance of pericoronary inflammation in epicardial functional stenosis and global coronary flow reserve
description	Abstract Both fractional flow reserve (FFR) and global coronary flow reserve (g-CFR) provide prognostic information in patients with stable coronary artery disease (CAD). Inflammation plays a vital role in impaired endothelial dysfunction and atherosclerotic progression, potentially predicting cardiovascular mortality. This study aimed to evaluate the physiological significance of pericoronary adipose tissue inflammation assessed by CT attenuation (PCATA) in epicardial functional stenosis severity and g-CFR in patients with CAD. A total of 131 CAD patients with a single de novo epicardial coronary stenosis who underwent coronary CT-angiography (CCTA), phase-contrast cine-magnetic resonance imaging (PC-CMR) and FFR measurement were studied. PCATA was assessed using the mean CT attenuation value. G-CFR was obtained by quantifying absolute coronary sinus flow (ml/min/g) by PC-CMR at rest and during maximum hyperemia. Median FFR, g-CFR, and PCATA values were 0.75, 2.59, and − 71.3, respectively. Serum creatinine, NT-proBNP, left ventricular end-diastolic volume, and PCATA were independently associated with g-CFR. PCATA showed a significant incremental predictive efficacy for impaired g-CFR (< 2.0) when added to the clinical risk model. PCATA was significantly associated with g-CFR, independent of FFR. Our results suggest the pathophysiological mechanisms linking perivascular inflammation with g-CFR in CAD patients.
format	article
author	Yoshihisa Kanaji Tomoyo Sugiyama Masahiro Hoshino Toru Misawa Tatsuhiro Nagamine Yumi Yasui Kai Nogami Hiroki Ueno Hidenori Hirano Masahiro Hada Masao Yamaguchi Rikuta Hamaya Eisuke Usui Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta
author_facet	Yoshihisa Kanaji Tomoyo Sugiyama Masahiro Hoshino Toru Misawa Tatsuhiro Nagamine Yumi Yasui Kai Nogami Hiroki Ueno Hidenori Hirano Masahiro Hada Masao Yamaguchi Rikuta Hamaya Eisuke Usui Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta
author_sort	Yoshihisa Kanaji
title	Physiological significance of pericoronary inflammation in epicardial functional stenosis and global coronary flow reserve
title_short	Physiological significance of pericoronary inflammation in epicardial functional stenosis and global coronary flow reserve
title_full	Physiological significance of pericoronary inflammation in epicardial functional stenosis and global coronary flow reserve
title_fullStr	Physiological significance of pericoronary inflammation in epicardial functional stenosis and global coronary flow reserve
title_full_unstemmed	Physiological significance of pericoronary inflammation in epicardial functional stenosis and global coronary flow reserve
title_sort	physiological significance of pericoronary inflammation in epicardial functional stenosis and global coronary flow reserve
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f8585ae5df1044e8b462d2ecdb7d5b23
work_keys_str_mv	AT yoshihisakanaji physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT tomoyosugiyama physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT masahirohoshino physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT torumisawa physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT tatsuhironagamine physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT yumiyasui physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT kainogami physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT hirokiueno physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT hidenorihirano physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT masahirohada physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT masaoyamaguchi physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT rikutahamaya physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT eisukeusui physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT taishiyonetsu physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT tetsuosasano physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve AT tsunekazukakuta physiologicalsignificanceofpericoronaryinflammationinepicardialfunctionalstenosisandglobalcoronaryflowreserve
_version_	1718380827949137920

Physiological significance of pericoronary inflammation in epicardial functional stenosis and global coronary flow reserve

Ejemplares similares