Positive metacognitions about alcohol mediate the relationship between FKBP5 variability and problematic drinking in a sample of young women

Wojciech Łukasz Dragan,1 Wojciech Domozych,1 Piotr M Czerski,2 Małgorzata Dragan3 1The Interdisciplinary Centre for Behavioural Genetics Research, Faculty of Psychology, University of Warsaw, Warsaw, Poland; 2Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical...

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Autores principales:	Dragan WŁ, Domozych W, Czerski PM, Dragan M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Metacognition FKBP5 alcohol abuse genetics PAMS. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f85c2b7bc2814845ad534a1598fdb46d
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spelling	oai:doaj.org-article:f85c2b7bc2814845ad534a1598fdb46d2021-12-02T05:25:05ZPositive metacognitions about alcohol mediate the relationship between FKBP5 variability and problematic drinking in a sample of young women1178-2021https://doaj.org/article/f85c2b7bc2814845ad534a1598fdb46d2018-10-01T00:00:00Zhttps://www.dovepress.com/positive-metacognitions-about-alcohol-mediate-the-relationship-between-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Wojciech Łukasz Dragan,1 Wojciech Domozych,1 Piotr M Czerski,2 Małgorzata Dragan3 1The Interdisciplinary Centre for Behavioural Genetics Research, Faculty of Psychology, University of Warsaw, Warsaw, Poland; 2Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland; 3Faculty of Psychology, University of Warsaw, Warsaw, Poland Background: Previous research has shown that polymorphisms in the FKBP5 gene are related to some psychiatric conditions, including alcohol dependence. These relationships are moderated by the level of adverse childhood experiences that one has undergone. Maladaptive metacognition, associated with symptoms of psychiatric disorders and disturbed emotional self-regulation, is also a strong predictor of problematic alcohol use. Recent studies suggest that maladaptive metacognitions may be part of the developmental pathway from childhood abuse to drinking problems. This study attempted to identify relationships between FKBP5 polymorphisms and metacognitions about the positive effects of alcohol use and problematic drinking in a group differing in levels of childhood trauma.Methods: The sample studied was composed of 502 female participants aged 18–25 years (M=21.78; SD=1.84). Positive metacognitions about alcohol use were measured with the Positive Alcohol Metacognitions Scale (PAMS) and problematic drinking was gauged using the WHO Alcohol Use Disorders Identification Test. Levels of childhood adverse experiences were determined with the use of the Childhood Questionnaire. A total of 18 single-nucleotide polymorphisms (SNPs) in the FKBP5 gene were genotyped.Results: We did not find any interaction between the gene and childhood trauma on problematic drinking or metacognitions. However we identified a strong main effect of two SNPs of the FKBP5 gene – rs755658 and rs1334894 – on the PAMS subscale measuring positive metacognitive beliefs about emotional self-regulation. We also found nominally significant relations of several other SNPs with metacognitions and problematic drinking. Additionally, we showed that positive alcohol metacognitions mediate the relationship between problematic drinking and both rs755658 and rs1334894.Conclusion: Our results may shed some light on the biological underpinnings of the developmental pathway leading to problematic drinking through maladaptive metacognitions. Keywords: maladaptive metacognition, FKBP5, problematic drinking, adverse childhood experiencesDragan WŁDomozych WCzerski PMDragan MDove Medical PressarticleMetacognitionFKBP5alcohol abusegeneticsPAMS.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2681-2688 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Metacognition FKBP5 alcohol abuse genetics PAMS. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Metacognition FKBP5 alcohol abuse genetics PAMS. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Dragan WŁ Domozych W Czerski PM Dragan M Positive metacognitions about alcohol mediate the relationship between FKBP5 variability and problematic drinking in a sample of young women
description	Wojciech Łukasz Dragan,1 Wojciech Domozych,1 Piotr M Czerski,2 Małgorzata Dragan3 1The Interdisciplinary Centre for Behavioural Genetics Research, Faculty of Psychology, University of Warsaw, Warsaw, Poland; 2Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland; 3Faculty of Psychology, University of Warsaw, Warsaw, Poland Background: Previous research has shown that polymorphisms in the FKBP5 gene are related to some psychiatric conditions, including alcohol dependence. These relationships are moderated by the level of adverse childhood experiences that one has undergone. Maladaptive metacognition, associated with symptoms of psychiatric disorders and disturbed emotional self-regulation, is also a strong predictor of problematic alcohol use. Recent studies suggest that maladaptive metacognitions may be part of the developmental pathway from childhood abuse to drinking problems. This study attempted to identify relationships between FKBP5 polymorphisms and metacognitions about the positive effects of alcohol use and problematic drinking in a group differing in levels of childhood trauma.Methods: The sample studied was composed of 502 female participants aged 18–25 years (M=21.78; SD=1.84). Positive metacognitions about alcohol use were measured with the Positive Alcohol Metacognitions Scale (PAMS) and problematic drinking was gauged using the WHO Alcohol Use Disorders Identification Test. Levels of childhood adverse experiences were determined with the use of the Childhood Questionnaire. A total of 18 single-nucleotide polymorphisms (SNPs) in the FKBP5 gene were genotyped.Results: We did not find any interaction between the gene and childhood trauma on problematic drinking or metacognitions. However we identified a strong main effect of two SNPs of the FKBP5 gene – rs755658 and rs1334894 – on the PAMS subscale measuring positive metacognitive beliefs about emotional self-regulation. We also found nominally significant relations of several other SNPs with metacognitions and problematic drinking. Additionally, we showed that positive alcohol metacognitions mediate the relationship between problematic drinking and both rs755658 and rs1334894.Conclusion: Our results may shed some light on the biological underpinnings of the developmental pathway leading to problematic drinking through maladaptive metacognitions. Keywords: maladaptive metacognition, FKBP5, problematic drinking, adverse childhood experiences
format	article
author	Dragan WŁ Domozych W Czerski PM Dragan M
author_facet	Dragan WŁ Domozych W Czerski PM Dragan M
author_sort	Dragan WŁ
title	Positive metacognitions about alcohol mediate the relationship between FKBP5 variability and problematic drinking in a sample of young women
title_short	Positive metacognitions about alcohol mediate the relationship between FKBP5 variability and problematic drinking in a sample of young women
title_full	Positive metacognitions about alcohol mediate the relationship between FKBP5 variability and problematic drinking in a sample of young women
title_fullStr	Positive metacognitions about alcohol mediate the relationship between FKBP5 variability and problematic drinking in a sample of young women
title_full_unstemmed	Positive metacognitions about alcohol mediate the relationship between FKBP5 variability and problematic drinking in a sample of young women
title_sort	positive metacognitions about alcohol mediate the relationship between fkbp5 variability and problematic drinking in a sample of young women
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f85c2b7bc2814845ad534a1598fdb46d
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Positive metacognitions about alcohol mediate the relationship between FKBP5 variability and problematic drinking in a sample of young women

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