Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.

Oxidative exposure of cells occurs naturally and may be associated with cellular damage and dysfunction. Protracted low level oxidative exposure can induce accumulated cell disruption, affecting multiple cellular functions. Accumulated oxidative exposure has also been proposed as one of the potentia...

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Autores principales:	Wayne Chadwick, Yu Zhou, Sung-Soo Park, Liyun Wang, Nicholas Mitchell, Matthew D Stone, Kevin G Becker, Bronwen Martin, Stuart Maudsley
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f866491f233e40ed97eccd52799cadb2
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spelling	oai:doaj.org-article:f866491f233e40ed97eccd52799cadb22021-11-18T07:01:36ZMinimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.1932-620310.1371/journal.pone.0014352https://doaj.org/article/f866491f233e40ed97eccd52799cadb22010-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21179406/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Oxidative exposure of cells occurs naturally and may be associated with cellular damage and dysfunction. Protracted low level oxidative exposure can induce accumulated cell disruption, affecting multiple cellular functions. Accumulated oxidative exposure has also been proposed as one of the potential hallmarks of the physiological/pathophysiological aging process. We investigated the multifactorial effects of long-term minimal peroxide exposure upon SH-SY5Y neural cells to understand how they respond to the continued presence of oxidative stressors. We show that minimal protracted oxidative stresses induce complex molecular and physiological alterations in cell functionality. Upon chronic exposure to minimal doses of hydrogen peroxide, SH-SY5Y cells displayed a multifactorial response to the stressor. To fully appreciate the peroxide-mediated cellular effects, we assessed these adaptive effects at the genomic, proteomic and cellular signal processing level. Combined analyses of these multiple levels of investigation revealed a complex cellular adaptive response to the protracted peroxide exposure. This adaptive response involved changes in cytoskeletal structure, energy metabolic shifts towards glycolysis and selective alterations in transmembrane receptor activity. Our analyses of the global responses to chronic stressor exposure, at multiple biological levels, revealed a viable neural phenotype in-part reminiscent of aged or damaged neural tissue. Our paradigm indicates how cellular physiology can subtly change in different contexts and potentially aid the appreciation of stress response adaptations.Wayne ChadwickYu ZhouSung-Soo ParkLiyun WangNicholas MitchellMatthew D StoneKevin G BeckerBronwen MartinStuart MaudsleyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 12, p e14352 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wayne Chadwick Yu Zhou Sung-Soo Park Liyun Wang Nicholas Mitchell Matthew D Stone Kevin G Becker Bronwen Martin Stuart Maudsley Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.
description	Oxidative exposure of cells occurs naturally and may be associated with cellular damage and dysfunction. Protracted low level oxidative exposure can induce accumulated cell disruption, affecting multiple cellular functions. Accumulated oxidative exposure has also been proposed as one of the potential hallmarks of the physiological/pathophysiological aging process. We investigated the multifactorial effects of long-term minimal peroxide exposure upon SH-SY5Y neural cells to understand how they respond to the continued presence of oxidative stressors. We show that minimal protracted oxidative stresses induce complex molecular and physiological alterations in cell functionality. Upon chronic exposure to minimal doses of hydrogen peroxide, SH-SY5Y cells displayed a multifactorial response to the stressor. To fully appreciate the peroxide-mediated cellular effects, we assessed these adaptive effects at the genomic, proteomic and cellular signal processing level. Combined analyses of these multiple levels of investigation revealed a complex cellular adaptive response to the protracted peroxide exposure. This adaptive response involved changes in cytoskeletal structure, energy metabolic shifts towards glycolysis and selective alterations in transmembrane receptor activity. Our analyses of the global responses to chronic stressor exposure, at multiple biological levels, revealed a viable neural phenotype in-part reminiscent of aged or damaged neural tissue. Our paradigm indicates how cellular physiology can subtly change in different contexts and potentially aid the appreciation of stress response adaptations.
format	article
author	Wayne Chadwick Yu Zhou Sung-Soo Park Liyun Wang Nicholas Mitchell Matthew D Stone Kevin G Becker Bronwen Martin Stuart Maudsley
author_facet	Wayne Chadwick Yu Zhou Sung-Soo Park Liyun Wang Nicholas Mitchell Matthew D Stone Kevin G Becker Bronwen Martin Stuart Maudsley
author_sort	Wayne Chadwick
title	Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.
title_short	Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.
title_full	Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.
title_fullStr	Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.
title_full_unstemmed	Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.
title_sort	minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/f866491f233e40ed97eccd52799cadb2
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Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.

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