ROLE OF PRO- AND ANTIANGIOGENIC FACTORS IN PLACENTAL DEVELOPMENT

Abstract. Vascular network of placenta exhibits plasticity, and undergoes various dynamic changes in the course of pregnancy. Placental development is controlled by various cytokines and growth factors, and their ratios show strong fluctuations during pregnancy. The purpose of present study was to e...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	D. I. Sokolov, A. V. Kolobov, M. V. Lesnichija, I. N. Kostiouchek, K. V. Bolya, O. N. Arzhanova, I. M. Kvetnoy, S. A. Selkov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	placenta angiogenesis vegf vegf-r1 bfgf mmp-2 il-8 pdgf tsp-1 tgfβ tgfβ-r1 cd105 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f87077b17ded438e85496e1f7b1bec72
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f87077b17ded438e85496e1f7b1bec72
record_format	dspace
spelling	oai:doaj.org-article:f87077b17ded438e85496e1f7b1bec722021-11-18T08:03:39ZROLE OF PRO- AND ANTIANGIOGENIC FACTORS IN PLACENTAL DEVELOPMENT1563-06252313-741X10.15789/1563-0625-2008-4-5-347-352https://doaj.org/article/f87077b17ded438e85496e1f7b1bec722014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/187https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Vascular network of placenta exhibits plasticity, and undergoes various dynamic changes in the course of pregnancy. Placental development is controlled by various cytokines and growth factors, and their ratios show strong fluctuations during pregnancy. The purpose of present study was to evaluate expression and secretion of proangiogenic and antiangiogenic factors by placental tissue at early stages (1st trimester) and late terms (3rd trimester) of normally proceeding pregnancy. It was established that at earlier stages (1st trimester), placental tissue produced larger quantities of proangiogenic factors (VEGF, PDGF, IL-8, MMP-2), in comparison to the 3rd trimester of pregnancy. By the 3rd trimester, VEGF-R3 expression and bFGF secretion by placental cells was also decreased, accompanied by increased production of angiogenin. Moreover, a suppressed production of antiangiogenic factors TSP-1 and TGFβ and expression of TGFβ-R1, CD105 receptors by placenta tissue was registered by the 3rd trimester of pregnancy. In permanently evolving placental tissue, an excess of angiogenic factors is observed. Meanwhile, antiangiogenic factors also seem to play an essential role in formation of placental tissue, thus providing angiogenesis inhibition.The study was supported by Presidential grants of Russian Federation N НШ-1066.2008.7, МК-1355.2007.7, and by a grant of Russian Foundation for Basic Research № 070400155. (Med. Immunol., vol. 10, N 4-5, pp 347-352).D. I. SokolovA. V. KolobovM. V. LesnichijaI. N. KostiouchekK. V. BolyaO. N. ArzhanovaI. M. KvetnoyS. A. SelkovSPb RAACIarticleplacentaangiogenesisvegfvegf-r1bfgfmmp-2il-8pdgftsp-1tgfβtgfβ-r1cd105Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 4-5, Pp 347-352 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	placenta angiogenesis vegf vegf-r1 bfgf mmp-2 il-8 pdgf tsp-1 tgfβ tgfβ-r1 cd105 Immunologic diseases. Allergy RC581-607
spellingShingle	placenta angiogenesis vegf vegf-r1 bfgf mmp-2 il-8 pdgf tsp-1 tgfβ tgfβ-r1 cd105 Immunologic diseases. Allergy RC581-607 D. I. Sokolov A. V. Kolobov M. V. Lesnichija I. N. Kostiouchek K. V. Bolya O. N. Arzhanova I. M. Kvetnoy S. A. Selkov ROLE OF PRO- AND ANTIANGIOGENIC FACTORS IN PLACENTAL DEVELOPMENT
description	Abstract. Vascular network of placenta exhibits plasticity, and undergoes various dynamic changes in the course of pregnancy. Placental development is controlled by various cytokines and growth factors, and their ratios show strong fluctuations during pregnancy. The purpose of present study was to evaluate expression and secretion of proangiogenic and antiangiogenic factors by placental tissue at early stages (1st trimester) and late terms (3rd trimester) of normally proceeding pregnancy. It was established that at earlier stages (1st trimester), placental tissue produced larger quantities of proangiogenic factors (VEGF, PDGF, IL-8, MMP-2), in comparison to the 3rd trimester of pregnancy. By the 3rd trimester, VEGF-R3 expression and bFGF secretion by placental cells was also decreased, accompanied by increased production of angiogenin. Moreover, a suppressed production of antiangiogenic factors TSP-1 and TGFβ and expression of TGFβ-R1, CD105 receptors by placenta tissue was registered by the 3rd trimester of pregnancy. In permanently evolving placental tissue, an excess of angiogenic factors is observed. Meanwhile, antiangiogenic factors also seem to play an essential role in formation of placental tissue, thus providing angiogenesis inhibition.The study was supported by Presidential grants of Russian Federation N НШ-1066.2008.7, МК-1355.2007.7, and by a grant of Russian Foundation for Basic Research № 070400155. (Med. Immunol., vol. 10, N 4-5, pp 347-352).
format	article
author	D. I. Sokolov A. V. Kolobov M. V. Lesnichija I. N. Kostiouchek K. V. Bolya O. N. Arzhanova I. M. Kvetnoy S. A. Selkov
author_facet	D. I. Sokolov A. V. Kolobov M. V. Lesnichija I. N. Kostiouchek K. V. Bolya O. N. Arzhanova I. M. Kvetnoy S. A. Selkov
author_sort	D. I. Sokolov
title	ROLE OF PRO- AND ANTIANGIOGENIC FACTORS IN PLACENTAL DEVELOPMENT
title_short	ROLE OF PRO- AND ANTIANGIOGENIC FACTORS IN PLACENTAL DEVELOPMENT
title_full	ROLE OF PRO- AND ANTIANGIOGENIC FACTORS IN PLACENTAL DEVELOPMENT
title_fullStr	ROLE OF PRO- AND ANTIANGIOGENIC FACTORS IN PLACENTAL DEVELOPMENT
title_full_unstemmed	ROLE OF PRO- AND ANTIANGIOGENIC FACTORS IN PLACENTAL DEVELOPMENT
title_sort	role of pro- and antiangiogenic factors in placental development
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/f87077b17ded438e85496e1f7b1bec72
work_keys_str_mv	AT disokolov roleofproandantiangiogenicfactorsinplacentaldevelopment AT avkolobov roleofproandantiangiogenicfactorsinplacentaldevelopment AT mvlesnichija roleofproandantiangiogenicfactorsinplacentaldevelopment AT inkostiouchek roleofproandantiangiogenicfactorsinplacentaldevelopment AT kvbolya roleofproandantiangiogenicfactorsinplacentaldevelopment AT onarzhanova roleofproandantiangiogenicfactorsinplacentaldevelopment AT imkvetnoy roleofproandantiangiogenicfactorsinplacentaldevelopment AT saselkov roleofproandantiangiogenicfactorsinplacentaldevelopment
_version_	1718422581741092864

ROLE OF PRO- AND ANTIANGIOGENIC FACTORS IN PLACENTAL DEVELOPMENT

Ejemplares similares