Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles

At the fly neuromuscular junction, postsynaptic receptor perturbation induces homeostatic enhancement of neurotransmitter release. Here, the authors show that the presynaptic proteasome controls a vesicle pool required for homeostatic plasticity and that dysbindin is required to access this pool.

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Autores principales:	Corinna Wentzel, Igor Delvendahl, Sebastian Sydlik, Oleg Georgiev, Martin Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f8718c0bcd3242a6a105ee35aaf02555
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spelling	oai:doaj.org-article:f8718c0bcd3242a6a105ee35aaf025552021-12-02T15:34:21ZDysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles10.1038/s41467-017-02494-02041-1723https://doaj.org/article/f8718c0bcd3242a6a105ee35aaf025552018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02494-0https://doaj.org/toc/2041-1723At the fly neuromuscular junction, postsynaptic receptor perturbation induces homeostatic enhancement of neurotransmitter release. Here, the authors show that the presynaptic proteasome controls a vesicle pool required for homeostatic plasticity and that dysbindin is required to access this pool.Corinna WentzelIgor DelvendahlSebastian SydlikOleg GeorgievMartin MüllerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Corinna Wentzel Igor Delvendahl Sebastian Sydlik Oleg Georgiev Martin Müller Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
description	At the fly neuromuscular junction, postsynaptic receptor perturbation induces homeostatic enhancement of neurotransmitter release. Here, the authors show that the presynaptic proteasome controls a vesicle pool required for homeostatic plasticity and that dysbindin is required to access this pool.
format	article
author	Corinna Wentzel Igor Delvendahl Sebastian Sydlik Oleg Georgiev Martin Müller
author_facet	Corinna Wentzel Igor Delvendahl Sebastian Sydlik Oleg Georgiev Martin Müller
author_sort	Corinna Wentzel
title	Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
title_short	Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
title_full	Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
title_fullStr	Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
title_full_unstemmed	Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
title_sort	dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f8718c0bcd3242a6a105ee35aaf02555
work_keys_str_mv	AT corinnawentzel dysbindinlinkspresynapticproteasomefunctiontohomeostaticrecruitmentoflowreleaseprobabilityvesicles AT igordelvendahl dysbindinlinkspresynapticproteasomefunctiontohomeostaticrecruitmentoflowreleaseprobabilityvesicles AT sebastiansydlik dysbindinlinkspresynapticproteasomefunctiontohomeostaticrecruitmentoflowreleaseprobabilityvesicles AT oleggeorgiev dysbindinlinkspresynapticproteasomefunctiontohomeostaticrecruitmentoflowreleaseprobabilityvesicles AT martinmuller dysbindinlinkspresynapticproteasomefunctiontohomeostaticrecruitmentoflowreleaseprobabilityvesicles
_version_	1718386878343806976

Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles

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